Effects of Lycii Fructus and Salviae Miltiorrhizae on the Syndrome of Deficiency with Blood Stasis in RCS (rdy-/-, p-/-) Rats with Retinitis Pigmentosa: An Intervention Study
Objective: To investigate the effects of Lycii Fructus (LF, Gou Qi Zi, 枸杞子) and Salviae Miltiorrhizae Radix Ex Rhizoma (SM, Dan Shen, 丹 参 ) on the syndrome of deficiency with blood stasis in the RCS (rdy-/-, p-/-) rats with retinitis pigmentosa (RP). Methods: A total of 32 RCS (rdy-/-, p-/-) rats we...
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doaj-4f0aee6dbc8546f8807f79aeb9d5b3db2020-11-25T01:20:22ZengKeAi Communications Co., Ltd.Digital Chinese Medicine2589-37772019-09-0123157165Effects of Lycii Fructus and Salviae Miltiorrhizae on the Syndrome of Deficiency with Blood Stasis in RCS (rdy-/-, p-/-) Rats with Retinitis Pigmentosa: An Intervention StudyXu Jian0Yang Yi-Jing1Qin Gen-Yan2Zhou Ya-Sha3Peng Jun4Peng Qing-Hua5The Domestic First-class Discipline Construction Project of Chinese Medicine of Hunan University of Chinese Medicine, Changsha, Hunan 410208, China; Department of Ophthalmology, Shanghai East Hospital, Shanghai 200120, ChinaThe Domestic First-class Discipline Construction Project of Chinese Medicine of Hunan University of Chinese Medicine, Changsha, Hunan 410208, China; Hunan Provincial Key Laboratory for Prevention and Treatment of Ophthalmology and Otolaryngology Diseases with Chinese Medicine, Changsha, Hunan 410208, ChinaDepartment of Ophthalmology, No.1 Traditional Chinese Medicine Hospital in Changde, Changde, Hunan 415000, ChinaThe Domestic First-class Discipline Construction Project of Chinese Medicine of Hunan University of Chinese Medicine, Changsha, Hunan 410208, China; Hunan Provincial Key Laboratory for Prevention and Treatment of Ophthalmology and Otolaryngology Diseases with Chinese Medicine, Changsha, Hunan 410208, ChinaDepartment of Ophthalmology, the First Hospital of Hunan University of Chinese Medicine, Changsha, Hunan 410007, China; Corresponding author. Research direction: Chinese medicine for prevention and treatment of fundus diseases.The Domestic First-class Discipline Construction Project of Chinese Medicine of Hunan University of Chinese Medicine, Changsha, Hunan 410208, China; Hunan Provincial Key Laboratory for Prevention and Treatment of Ophthalmology and Otolaryngology Diseases with Chinese Medicine, Changsha, Hunan 410208, China; Department of Ophthalmology, the First Hospital of Hunan University of Chinese Medicine, Changsha, Hunan 410007, China; Corresponding author. Research direction: Chinese medicine for prevention and treatment of ocular surface and fundus diseases.Objective: To investigate the effects of Lycii Fructus (LF, Gou Qi Zi, 枸杞子) and Salviae Miltiorrhizae Radix Ex Rhizoma (SM, Dan Shen, 丹 参 ) on the syndrome of deficiency with blood stasis in the RCS (rdy-/-, p-/-) rats with retinitis pigmentosa (RP). Methods: A total of 32 RCS (rdy-/-, p-/-) rats were divided into 4 groups (equal amounts of female and male rats in each group): model group treated with 0.9% normal saline, LF group treated with LF formula granules, SM group treated with SM formula granules, and LF and SM (L·S) group treated with LF and SM formula granules. Eight RCS (rdy +/ +, p +/ +) rats (4 males and 4 females) were treated with 0.9% normal saline to serve as blank group. The contents of E2, PG, P-Selectin, plasma viscosity, whole blood relative index of the high shear rate and fibrinogen content in plasma, and the content of cAMP and cGMP in retinal homogenate were detected. The retina was evaluated by hematoxylin-eosin staining. Results: The contents of E2, PG, P-Selectin, plasma viscosity, whole blood relative index of the high shear rate, and fibrinogen content in the plasma of L·S group significantly differed from those of model group (P < 0.01), but were similar to those of blank group. The contents of cAMP and cGMP in the retinal homogenate of L·S group significantly differed from those in model group (P < 0.01) but were similar to those in blank group (P > 0.05). Conclusions: LF and SM can effectively treat retinitis pigmentosa by ameliorating the syndrome of deficiency with blood stasis. Keywords: Retinitis pigmentosa (RP), Lycii Fructus (Gou Qi Zi, 枸;杞;子;), Salviae Miltiorrhizae Radix Ex Rhizoma (Dan Shen, 丹;参;), Syndrome of deficiency with blood stasis, RCS (rdy-/-, p-/-) rathttp://www.sciencedirect.com/science/article/pii/S2589377719301107 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Xu Jian Yang Yi-Jing Qin Gen-Yan Zhou Ya-Sha Peng Jun Peng Qing-Hua |
spellingShingle |
Xu Jian Yang Yi-Jing Qin Gen-Yan Zhou Ya-Sha Peng Jun Peng Qing-Hua Effects of Lycii Fructus and Salviae Miltiorrhizae on the Syndrome of Deficiency with Blood Stasis in RCS (rdy-/-, p-/-) Rats with Retinitis Pigmentosa: An Intervention Study Digital Chinese Medicine |
author_facet |
Xu Jian Yang Yi-Jing Qin Gen-Yan Zhou Ya-Sha Peng Jun Peng Qing-Hua |
author_sort |
Xu Jian |
title |
Effects of Lycii Fructus and Salviae Miltiorrhizae on the Syndrome of Deficiency with Blood Stasis in RCS (rdy-/-, p-/-) Rats with Retinitis Pigmentosa: An Intervention Study |
title_short |
Effects of Lycii Fructus and Salviae Miltiorrhizae on the Syndrome of Deficiency with Blood Stasis in RCS (rdy-/-, p-/-) Rats with Retinitis Pigmentosa: An Intervention Study |
title_full |
Effects of Lycii Fructus and Salviae Miltiorrhizae on the Syndrome of Deficiency with Blood Stasis in RCS (rdy-/-, p-/-) Rats with Retinitis Pigmentosa: An Intervention Study |
title_fullStr |
Effects of Lycii Fructus and Salviae Miltiorrhizae on the Syndrome of Deficiency with Blood Stasis in RCS (rdy-/-, p-/-) Rats with Retinitis Pigmentosa: An Intervention Study |
title_full_unstemmed |
Effects of Lycii Fructus and Salviae Miltiorrhizae on the Syndrome of Deficiency with Blood Stasis in RCS (rdy-/-, p-/-) Rats with Retinitis Pigmentosa: An Intervention Study |
title_sort |
effects of lycii fructus and salviae miltiorrhizae on the syndrome of deficiency with blood stasis in rcs (rdy-/-, p-/-) rats with retinitis pigmentosa: an intervention study |
publisher |
KeAi Communications Co., Ltd. |
series |
Digital Chinese Medicine |
issn |
2589-3777 |
publishDate |
2019-09-01 |
description |
Objective: To investigate the effects of Lycii Fructus (LF, Gou Qi Zi, 枸杞子) and Salviae Miltiorrhizae Radix Ex Rhizoma (SM, Dan Shen, 丹 参 ) on the syndrome of deficiency with blood stasis in the RCS (rdy-/-, p-/-) rats with retinitis pigmentosa (RP). Methods: A total of 32 RCS (rdy-/-, p-/-) rats were divided into 4 groups (equal amounts of female and male rats in each group): model group treated with 0.9% normal saline, LF group treated with LF formula granules, SM group treated with SM formula granules, and LF and SM (L·S) group treated with LF and SM formula granules. Eight RCS (rdy +/ +, p +/ +) rats (4 males and 4 females) were treated with 0.9% normal saline to serve as blank group. The contents of E2, PG, P-Selectin, plasma viscosity, whole blood relative index of the high shear rate and fibrinogen content in plasma, and the content of cAMP and cGMP in retinal homogenate were detected. The retina was evaluated by hematoxylin-eosin staining. Results: The contents of E2, PG, P-Selectin, plasma viscosity, whole blood relative index of the high shear rate, and fibrinogen content in the plasma of L·S group significantly differed from those of model group (P < 0.01), but were similar to those of blank group. The contents of cAMP and cGMP in the retinal homogenate of L·S group significantly differed from those in model group (P < 0.01) but were similar to those in blank group (P > 0.05). Conclusions: LF and SM can effectively treat retinitis pigmentosa by ameliorating the syndrome of deficiency with blood stasis. Keywords: Retinitis pigmentosa (RP), Lycii Fructus (Gou Qi Zi, 枸;杞;子;), Salviae Miltiorrhizae Radix Ex Rhizoma (Dan Shen, 丹;参;), Syndrome of deficiency with blood stasis, RCS (rdy-/-, p-/-) rat |
url |
http://www.sciencedirect.com/science/article/pii/S2589377719301107 |
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