Machine learning for the prediction of bone metastasis in patients with newly diagnosed thyroid cancer
Abstract Objectives This study aimed to establish a machine learning prediction model that can be used to predict bone metastasis (BM) in patients with newly diagnosed thyroid cancer (TC). Methods Demographic and clinicopathologic variables of TC patients in the Surveillance, Epidemiology, and End R...
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Online Access: | https://doi.org/10.1002/cam4.3776 |
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doaj-4f0f5509baaa49bf976d640926f6d5ef2021-04-08T04:25:01ZengWileyCancer Medicine2045-76342021-04-011082802281110.1002/cam4.3776Machine learning for the prediction of bone metastasis in patients with newly diagnosed thyroid cancerWen‐Cai Liu0Zhi‐Qiang Li1Zhi‐Wen Luo2Wei‐Jie Liao3Zhi‐Li Liu4Jia‐Ming Liu5Department of Orthopaedic Surgery The First Affiliated Hospital of Nanchang University Nanchang PR ChinaDepartment of Orthopaedic Surgery The First Affiliated Hospital of Nanchang University Nanchang PR ChinaDepartment of Orthopaedic Surgery The First Affiliated Hospital of Nanchang University Nanchang PR ChinaDepartment of Orthopaedic Surgery The First Affiliated Hospital of Nanchang University Nanchang PR ChinaDepartment of Orthopaedic Surgery The First Affiliated Hospital of Nanchang University Nanchang PR ChinaDepartment of Orthopaedic Surgery The First Affiliated Hospital of Nanchang University Nanchang PR ChinaAbstract Objectives This study aimed to establish a machine learning prediction model that can be used to predict bone metastasis (BM) in patients with newly diagnosed thyroid cancer (TC). Methods Demographic and clinicopathologic variables of TC patients in the Surveillance, Epidemiology, and End Results database from 2010 to 2016 were retrospectively analyzed. On this basis, we developed a random forest (RF) algorithm model based on machine‐learning. The area under receiver operating characteristic curve (AUC), accuracy score, recall rate, and specificity are used to evaluate and compare the prediction performance of the RF model and the other model. Results A total of 17,138 patients were included in the study, with 166 (0.97%) developed bone metastases. Grade, T stage, histology, race, sex, age, and N stage were the important prediction features of BM. The RF model has better predictive performance than the other model (AUC: 0.917, accuracy: 0.904, recall rate: 0.833, and specificity: 0.905). Conclusions The RF model constructed in this study could accurately predict bone metastases in TC patients, which may provide clinicians with more personalized clinical decision‐making recommendations. Machine learning technology has the potential to improve the development of BM prediction models in TC patients.https://doi.org/10.1002/cam4.3776bone metastasismachine learningrandom forestSEERthyroid cancer |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Wen‐Cai Liu Zhi‐Qiang Li Zhi‐Wen Luo Wei‐Jie Liao Zhi‐Li Liu Jia‐Ming Liu |
spellingShingle |
Wen‐Cai Liu Zhi‐Qiang Li Zhi‐Wen Luo Wei‐Jie Liao Zhi‐Li Liu Jia‐Ming Liu Machine learning for the prediction of bone metastasis in patients with newly diagnosed thyroid cancer Cancer Medicine bone metastasis machine learning random forest SEER thyroid cancer |
author_facet |
Wen‐Cai Liu Zhi‐Qiang Li Zhi‐Wen Luo Wei‐Jie Liao Zhi‐Li Liu Jia‐Ming Liu |
author_sort |
Wen‐Cai Liu |
title |
Machine learning for the prediction of bone metastasis in patients with newly diagnosed thyroid cancer |
title_short |
Machine learning for the prediction of bone metastasis in patients with newly diagnosed thyroid cancer |
title_full |
Machine learning for the prediction of bone metastasis in patients with newly diagnosed thyroid cancer |
title_fullStr |
Machine learning for the prediction of bone metastasis in patients with newly diagnosed thyroid cancer |
title_full_unstemmed |
Machine learning for the prediction of bone metastasis in patients with newly diagnosed thyroid cancer |
title_sort |
machine learning for the prediction of bone metastasis in patients with newly diagnosed thyroid cancer |
publisher |
Wiley |
series |
Cancer Medicine |
issn |
2045-7634 |
publishDate |
2021-04-01 |
description |
Abstract Objectives This study aimed to establish a machine learning prediction model that can be used to predict bone metastasis (BM) in patients with newly diagnosed thyroid cancer (TC). Methods Demographic and clinicopathologic variables of TC patients in the Surveillance, Epidemiology, and End Results database from 2010 to 2016 were retrospectively analyzed. On this basis, we developed a random forest (RF) algorithm model based on machine‐learning. The area under receiver operating characteristic curve (AUC), accuracy score, recall rate, and specificity are used to evaluate and compare the prediction performance of the RF model and the other model. Results A total of 17,138 patients were included in the study, with 166 (0.97%) developed bone metastases. Grade, T stage, histology, race, sex, age, and N stage were the important prediction features of BM. The RF model has better predictive performance than the other model (AUC: 0.917, accuracy: 0.904, recall rate: 0.833, and specificity: 0.905). Conclusions The RF model constructed in this study could accurately predict bone metastases in TC patients, which may provide clinicians with more personalized clinical decision‐making recommendations. Machine learning technology has the potential to improve the development of BM prediction models in TC patients. |
topic |
bone metastasis machine learning random forest SEER thyroid cancer |
url |
https://doi.org/10.1002/cam4.3776 |
work_keys_str_mv |
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