Factors Associated with Gestational Diabetes Mellitus: A Meta-Analysis
Gestational diabetes mellitus (GDM) is a major public health issue, and the aim of the present study was to identify the factors associated with GDM. Databases were searched for observational studies until August 20, 2020. Pooled odds ratios (ORs) were calculated using fixed- or random-effects model...
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Series: | Journal of Diabetes Research |
Online Access: | http://dx.doi.org/10.1155/2021/6692695 |
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doaj-4f0f6dd84c8b46408f47fdb26fdc0c1c2021-05-24T00:15:28ZengHindawi LimitedJournal of Diabetes Research2314-67532021-01-01202110.1155/2021/6692695Factors Associated with Gestational Diabetes Mellitus: A Meta-AnalysisYu Zhang0Cheng-Ming Xiao1Yan Zhang2Qiong Chen3Xiao-Qin Zhang4Xue-Feng Li5Ru-Yue Shao6Yi-Meng Gao7Department of Obstetrics and GynecologyDepartment of Obstetrics and GynecologyDepartment of Obstetrics and GynecologyDepartment of Obstetrics and GynecologyDepartment of Obstetrics and GynecologyDepartment of Obstetrics and GynecologySchool of Clinical MedicineDepartment of Obstetrics and GynecologyGestational diabetes mellitus (GDM) is a major public health issue, and the aim of the present study was to identify the factors associated with GDM. Databases were searched for observational studies until August 20, 2020. Pooled odds ratios (ORs) were calculated using fixed- or random-effects models. 103 studies involving 1,826,454 pregnant women were identified. Results indicated that maternal age≥25 years (OR: 2.466, 95% CI: (2.121, 2.866)), prepregnancy overweight or obese (OR: 2.637, 95% CI: (1.561, 4.453)), family history of diabetes (FHD) (OR: 2.326, 95% CI: (1.904, 2.843)), history of GDM (OR: 21.137, 95% CI: (8.785, 50.858)), macrosomia (OR: 2.539, 95% CI: (1.612, 4.000)), stillbirth (OR: 2.341, 95% CI: (1.435, 3.819)), premature delivery (OR: 3.013, 95% CI: (1.569, 5.787)), and pregestational smoking (OR: 2.322, 95% CI: (1.359, 3.967)) increased the risk of GDM with all P<0.05, whereas history of congenital anomaly and abortion, and HIV status showed no correlation with GDM (P>0.05). Being primigravida (OR: 0.752, 95% CI: (0.698, 0.810), P<0.001) reduced the risk of GDM. The factors influencing GDM included maternal age≥25, prepregnancy overweight or obese, FHD, history of GDM, macrosomia, stillbirth, premature delivery, pregestational smoking, and primigravida.http://dx.doi.org/10.1155/2021/6692695 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yu Zhang Cheng-Ming Xiao Yan Zhang Qiong Chen Xiao-Qin Zhang Xue-Feng Li Ru-Yue Shao Yi-Meng Gao |
spellingShingle |
Yu Zhang Cheng-Ming Xiao Yan Zhang Qiong Chen Xiao-Qin Zhang Xue-Feng Li Ru-Yue Shao Yi-Meng Gao Factors Associated with Gestational Diabetes Mellitus: A Meta-Analysis Journal of Diabetes Research |
author_facet |
Yu Zhang Cheng-Ming Xiao Yan Zhang Qiong Chen Xiao-Qin Zhang Xue-Feng Li Ru-Yue Shao Yi-Meng Gao |
author_sort |
Yu Zhang |
title |
Factors Associated with Gestational Diabetes Mellitus: A Meta-Analysis |
title_short |
Factors Associated with Gestational Diabetes Mellitus: A Meta-Analysis |
title_full |
Factors Associated with Gestational Diabetes Mellitus: A Meta-Analysis |
title_fullStr |
Factors Associated with Gestational Diabetes Mellitus: A Meta-Analysis |
title_full_unstemmed |
Factors Associated with Gestational Diabetes Mellitus: A Meta-Analysis |
title_sort |
factors associated with gestational diabetes mellitus: a meta-analysis |
publisher |
Hindawi Limited |
series |
Journal of Diabetes Research |
issn |
2314-6753 |
publishDate |
2021-01-01 |
description |
Gestational diabetes mellitus (GDM) is a major public health issue, and the aim of the present study was to identify the factors associated with GDM. Databases were searched for observational studies until August 20, 2020. Pooled odds ratios (ORs) were calculated using fixed- or random-effects models. 103 studies involving 1,826,454 pregnant women were identified. Results indicated that maternal age≥25 years (OR: 2.466, 95% CI: (2.121, 2.866)), prepregnancy overweight or obese (OR: 2.637, 95% CI: (1.561, 4.453)), family history of diabetes (FHD) (OR: 2.326, 95% CI: (1.904, 2.843)), history of GDM (OR: 21.137, 95% CI: (8.785, 50.858)), macrosomia (OR: 2.539, 95% CI: (1.612, 4.000)), stillbirth (OR: 2.341, 95% CI: (1.435, 3.819)), premature delivery (OR: 3.013, 95% CI: (1.569, 5.787)), and pregestational smoking (OR: 2.322, 95% CI: (1.359, 3.967)) increased the risk of GDM with all P<0.05, whereas history of congenital anomaly and abortion, and HIV status showed no correlation with GDM (P>0.05). Being primigravida (OR: 0.752, 95% CI: (0.698, 0.810), P<0.001) reduced the risk of GDM. The factors influencing GDM included maternal age≥25, prepregnancy overweight or obese, FHD, history of GDM, macrosomia, stillbirth, premature delivery, pregestational smoking, and primigravida. |
url |
http://dx.doi.org/10.1155/2021/6692695 |
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