Gelatin methacrylate-alginate hydrogel with tunable viscoelastic properties
Although native extracellular matrix (ECM) is viscoelastic, synthetic biomaterials used in biomedical engineering to mimic ECM typically exhibit a purely elastic response when an external strain is applied. In an effort to truly understand how living cells interact with surrounding ECM matrix, new b...
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doaj-4f18b48b0acd4eeeb4f7c3e803ac84092020-11-25T01:06:44ZengAIMS PressAIMS Materials Science2372-04842017-02-014236336910.3934/matersci.2017.2.363matersci-04-00363Gelatin methacrylate-alginate hydrogel with tunable viscoelastic propertiesYong X. Chen0Brian Cain1Pranav Soman2Essen Bioscience Inc. 300 W Morgan Rd, Ann Arbor, MI 48108 USADraper Laboratory: 555 Technology Square, Cambridge, MA 02139 USADepartment of Biomedical and Chemical Engineering, Syracuse University, 900 S Crouse Ave, Syracuse NY 13210 USAAlthough native extracellular matrix (ECM) is viscoelastic, synthetic biomaterials used in biomedical engineering to mimic ECM typically exhibit a purely elastic response when an external strain is applied. In an effort to truly understand how living cells interact with surrounding ECM matrix, new biomaterials with tunable viscoelastic properties continue to be developed. Here we report the synthesis and mechanical characterization of a gelatin methacrylate-alginate (Gel-Alg) composite hydrogel. Results obtained from creep and compressive tests reveal that the alginate component of Gel-Alg composite, can be effectively crosslinked, un-crosslinked and re-crosslinked by adding or chelating Ca<sup>2+</sup> ions. This work demonstrates that Gel-Alg is capable of tuning its viscoelastic strain and elastic recovery properties, and can be potentially used to design ECM-mimicking hydrogels.http://www.aimspress.com/Materials/article/1277/fulltext.htmlgelatinalginatehydrogelviscoelastic propertieselastic recovery |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yong X. Chen Brian Cain Pranav Soman |
spellingShingle |
Yong X. Chen Brian Cain Pranav Soman Gelatin methacrylate-alginate hydrogel with tunable viscoelastic properties AIMS Materials Science gelatin alginate hydrogel viscoelastic properties elastic recovery |
author_facet |
Yong X. Chen Brian Cain Pranav Soman |
author_sort |
Yong X. Chen |
title |
Gelatin methacrylate-alginate hydrogel with tunable viscoelastic properties |
title_short |
Gelatin methacrylate-alginate hydrogel with tunable viscoelastic properties |
title_full |
Gelatin methacrylate-alginate hydrogel with tunable viscoelastic properties |
title_fullStr |
Gelatin methacrylate-alginate hydrogel with tunable viscoelastic properties |
title_full_unstemmed |
Gelatin methacrylate-alginate hydrogel with tunable viscoelastic properties |
title_sort |
gelatin methacrylate-alginate hydrogel with tunable viscoelastic properties |
publisher |
AIMS Press |
series |
AIMS Materials Science |
issn |
2372-0484 |
publishDate |
2017-02-01 |
description |
Although native extracellular matrix (ECM) is viscoelastic, synthetic biomaterials used in biomedical engineering to mimic ECM typically exhibit a purely elastic response when an external strain is applied. In an effort to truly understand how living cells interact with surrounding ECM matrix, new biomaterials with tunable viscoelastic properties continue to be developed. Here we report the synthesis and mechanical characterization of a gelatin methacrylate-alginate (Gel-Alg) composite hydrogel. Results obtained from creep and compressive tests reveal that the alginate component of Gel-Alg composite, can be effectively crosslinked, un-crosslinked and re-crosslinked by adding or chelating Ca<sup>2+</sup> ions. This work demonstrates that Gel-Alg is capable of tuning its viscoelastic strain and elastic recovery properties, and can be potentially used to design ECM-mimicking hydrogels. |
topic |
gelatin alginate hydrogel viscoelastic properties elastic recovery |
url |
http://www.aimspress.com/Materials/article/1277/fulltext.html |
work_keys_str_mv |
AT yongxchen gelatinmethacrylatealginatehydrogelwithtunableviscoelasticproperties AT briancain gelatinmethacrylatealginatehydrogelwithtunableviscoelasticproperties AT pranavsoman gelatinmethacrylatealginatehydrogelwithtunableviscoelasticproperties |
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1725188443675295744 |