Optimizations of siRNA design for the activation of gene transcription by targeting the TATA-box motif.

Optimizations of siRNA design for the activation of gene transcription by targeting the TATA-box motif.

Small interfering RNAs (siRNAs) are widely used to repress gene expression by targeting mRNAs. Some reports reveal that siRNAs can also activate or inhibit gene expression through targeting the gene promoters. Our group has found that microRNAs (miRNAs) could activate gene transcription via interact...

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Bibliographic Details
Main Authors: Miaomiao Fan, Yijun Zhang, Zhuoqiong Huang, Jun Liu, Xuemin Guo, Hui Zhang, Haihua Luo
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4176967?pdf=render

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