Optimizations of siRNA design for the activation of gene transcription by targeting the TATA-box motif.
Small interfering RNAs (siRNAs) are widely used to repress gene expression by targeting mRNAs. Some reports reveal that siRNAs can also activate or inhibit gene expression through targeting the gene promoters. Our group has found that microRNAs (miRNAs) could activate gene transcription via interact...
Main Authors: | Miaomiao Fan, Yijun Zhang, Zhuoqiong Huang, Jun Liu, Xuemin Guo, Hui Zhang, Haihua Luo |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2014-01-01
|
Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC4176967?pdf=render |
Similar Items
-
The TATA-box motif and its impact on transcriptional gene regulation by miRNAs
by: Granados-Riveron Javier T., et al.
Published: (2015-04-01) -
TC-motifs at the TATA-box expected position in plant genes: a novel class of motifs involved in the transcription regulation
by: Lecharny Alain, et al.
Published: (2010-03-01) -
Targeted Delivery of siRNA
by: Sabrina Oliveira, et al.
Published: (2006-01-01) -
siRNA Mediate RNA Interference Concordant with Early On-Target Transient Transcriptional Interference
by: Zhiming Fang, et al.
Published: (2021-08-01) -
siRNA Targeting and Treatment of Gastrointestinal Diseases
by: Rachel Chevalier
Published: (2019-11-01)