Sinus Bradycardia Associated with Remdesivir Treatment in COVID-19: A Case Report and Literature Review
Background: Although remdesivir treatment is widely used during the pandemic coronavirus disease 2019 (COVID-19), there is scarce evidence regarding its cardiac side effects. Case presentation: We report the case of a 36-year-old male hospitalized due to severe COVID-19 symptoms. He presented with a...
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doaj-4f4ddd22dd984cb8a61d1222556525de2021-02-13T00:02:53ZengMDPI AGJournal of Cardiovascular Development and Disease2308-34252021-02-018181810.3390/jcdd8020018Sinus Bradycardia Associated with Remdesivir Treatment in COVID-19: A Case Report and Literature ReviewFotios Barkas0Chrysoula-Paraskevi Styla1Aris Bechlioulis2Haralampos Milionis3Evangelos Liberopoulos4Department of Internal Medicine, University Hospital of Ioannina, 45110 Ioannina, GreeceDepartment of Internal Medicine, University Hospital of Ioannina, 45110 Ioannina, GreeceDepartment of Cardiology, University Hospital of Ioannina, 45110 Ioannina, GreeceDepartment of Internal Medicine, University Hospital of Ioannina, 45110 Ioannina, GreeceDepartment of Internal Medicine, University Hospital of Ioannina, 45110 Ioannina, GreeceBackground: Although remdesivir treatment is widely used during the pandemic coronavirus disease 2019 (COVID-19), there is scarce evidence regarding its cardiac side effects. Case presentation: We report the case of a 36-year-old male hospitalized due to severe COVID-19 symptoms. He presented with a 10-day history of fever (up to 39.7 °C), productive cough, hemoptysis, fatigue, myalgias and hypoxemia. The patient received supplemental oxygen, dexamethasone, remdesivir and empirical antibiotic treatment according to protocol. Asymptomatic sinus bradycardia developed on hospital day 3 (namely, heart rate 39/min compared to 92/min on admission). Secondary causes of bradycardia were excluded based on the absence of relevant evidence from laboratory work-up and echocardiographic examination. The patient’s rhythm restored to normal 9 days after the discontinuation of remdesivir. Conclusions: Considering the frequent use of remdesivir in patients with COVID-19, physicians should be aware of this possible adverse event.https://www.mdpi.com/2308-3425/8/2/18SARS-CoV-2COVID-19remdesivirbradycardiaarrhythmia |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Fotios Barkas Chrysoula-Paraskevi Styla Aris Bechlioulis Haralampos Milionis Evangelos Liberopoulos |
spellingShingle |
Fotios Barkas Chrysoula-Paraskevi Styla Aris Bechlioulis Haralampos Milionis Evangelos Liberopoulos Sinus Bradycardia Associated with Remdesivir Treatment in COVID-19: A Case Report and Literature Review Journal of Cardiovascular Development and Disease SARS-CoV-2 COVID-19 remdesivir bradycardia arrhythmia |
author_facet |
Fotios Barkas Chrysoula-Paraskevi Styla Aris Bechlioulis Haralampos Milionis Evangelos Liberopoulos |
author_sort |
Fotios Barkas |
title |
Sinus Bradycardia Associated with Remdesivir Treatment in COVID-19: A Case Report and Literature Review |
title_short |
Sinus Bradycardia Associated with Remdesivir Treatment in COVID-19: A Case Report and Literature Review |
title_full |
Sinus Bradycardia Associated with Remdesivir Treatment in COVID-19: A Case Report and Literature Review |
title_fullStr |
Sinus Bradycardia Associated with Remdesivir Treatment in COVID-19: A Case Report and Literature Review |
title_full_unstemmed |
Sinus Bradycardia Associated with Remdesivir Treatment in COVID-19: A Case Report and Literature Review |
title_sort |
sinus bradycardia associated with remdesivir treatment in covid-19: a case report and literature review |
publisher |
MDPI AG |
series |
Journal of Cardiovascular Development and Disease |
issn |
2308-3425 |
publishDate |
2021-02-01 |
description |
Background: Although remdesivir treatment is widely used during the pandemic coronavirus disease 2019 (COVID-19), there is scarce evidence regarding its cardiac side effects. Case presentation: We report the case of a 36-year-old male hospitalized due to severe COVID-19 symptoms. He presented with a 10-day history of fever (up to 39.7 °C), productive cough, hemoptysis, fatigue, myalgias and hypoxemia. The patient received supplemental oxygen, dexamethasone, remdesivir and empirical antibiotic treatment according to protocol. Asymptomatic sinus bradycardia developed on hospital day 3 (namely, heart rate 39/min compared to 92/min on admission). Secondary causes of bradycardia were excluded based on the absence of relevant evidence from laboratory work-up and echocardiographic examination. The patient’s rhythm restored to normal 9 days after the discontinuation of remdesivir. Conclusions: Considering the frequent use of remdesivir in patients with COVID-19, physicians should be aware of this possible adverse event. |
topic |
SARS-CoV-2 COVID-19 remdesivir bradycardia arrhythmia |
url |
https://www.mdpi.com/2308-3425/8/2/18 |
work_keys_str_mv |
AT fotiosbarkas sinusbradycardiaassociatedwithremdesivirtreatmentincovid19acasereportandliteraturereview AT chrysoulaparaskevistyla sinusbradycardiaassociatedwithremdesivirtreatmentincovid19acasereportandliteraturereview AT arisbechlioulis sinusbradycardiaassociatedwithremdesivirtreatmentincovid19acasereportandliteraturereview AT haralamposmilionis sinusbradycardiaassociatedwithremdesivirtreatmentincovid19acasereportandliteraturereview AT evangelosliberopoulos sinusbradycardiaassociatedwithremdesivirtreatmentincovid19acasereportandliteraturereview |
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