Mode of progression after radioembolization in patients with colorectal cancer liver metastases
Abstract Background Radioembolization is an established treatment modality in colorectal cancer patients with liver-dominant disease in a salvage setting. Selection of patients who will benefit most is of vital importance. The aim of this study was to assess response (and mode of progression) at 3 m...
Main Authors: | , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
SpringerOpen
2020-09-01
|
Series: | EJNMMI Research |
Subjects: | |
Online Access: | http://link.springer.com/article/10.1186/s13550-020-00697-z |
id |
doaj-4f504335a13044408b8198cf21dcb547 |
---|---|
record_format |
Article |
spelling |
doaj-4f504335a13044408b8198cf21dcb5472020-11-25T02:49:32ZengSpringerOpenEJNMMI Research2191-219X2020-09-0110111310.1186/s13550-020-00697-zMode of progression after radioembolization in patients with colorectal cancer liver metastasesCaren van Roekel0Jennifer M. J. Jongen1Maarten L. J. Smits2Sjoerd G. Elias3Miriam Koopman4Onno Kranenburg5Inne H. M. Borel Rinkes6Marnix G. E. H. Lam7Department of Radiology and Nuclear Medicine, University Medical Center Utrecht, University UtrechtDepartment of Surgical Oncology, Endocrine and GI Surgery, Cancer Center, University Medical Center Utrecht, University UtrechtDepartment of Radiology and Nuclear Medicine, University Medical Center Utrecht, University UtrechtJulius Center for Health Sciences and Primary Care, University Medical Center Utrecht, University UtrechtDepartment of Medical Oncology, Cancer Center, University Medical Center Utrecht, University UtrechtDivision of Biomedical Genetics, University Medical Center Utrecht, University UtrechtDepartment of Surgical Oncology, Endocrine and GI Surgery, Cancer Center, University Medical Center Utrecht, University UtrechtDepartment of Radiology and Nuclear Medicine, University Medical Center Utrecht, University UtrechtAbstract Background Radioembolization is an established treatment modality in colorectal cancer patients with liver-dominant disease in a salvage setting. Selection of patients who will benefit most is of vital importance. The aim of this study was to assess response (and mode of progression) at 3 months after radioembolization and the impact of baseline characteristics. Methods Three months after radioembolization with either yttrium-90 resin/glass or holmium-166, anatomic response, according to RECIST 1.1, was evaluated in 90 patients. Correlations between baseline characteristics and efficacy were evaluated. For more detailed analysis of progressive disease as a dismal clinical entity, distinction was made between intra- and extrahepatic progression, and between progression of existing metastases and new metastases. Results Forty-two patients (47%) had extrahepatic disease (up to five ≥ 1 cm lung nodules, and ≤ 2 cm lymph nodes) at baseline. No patients showed complete response, 5 (5.5%) patients had partial response, 16 (17.8%) had stable disease, and 69 (76.7%) had progressive disease. Most progressive patients (67/69; 97%) had new metastases (intra-hepatic N = 11, extrahepatic N = 32; or both N = 24). Significantly fewer patients had progressive disease in the group of patients presenting without extrahepatic metastases at baseline (63% versus 93%; p = 0.0016). Median overall survival in patients with extrahepatic disease was 6.5 months, versus 10 months in patients without extrahepatic disease at baseline (hazard ratio 1.79, 95%CI 1.24–2.57). Conclusions Response at 3-month follow-up and survival were heavily influenced by new metastases. Patients with extrahepatic disease at baseline had a worse outcome compared to patients without.http://link.springer.com/article/10.1186/s13550-020-00697-zMetastatic colorectal cancerRadioembolizationProgressionRECISTExtrahepatic metastases |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Caren van Roekel Jennifer M. J. Jongen Maarten L. J. Smits Sjoerd G. Elias Miriam Koopman Onno Kranenburg Inne H. M. Borel Rinkes Marnix G. E. H. Lam |
spellingShingle |
Caren van Roekel Jennifer M. J. Jongen Maarten L. J. Smits Sjoerd G. Elias Miriam Koopman Onno Kranenburg Inne H. M. Borel Rinkes Marnix G. E. H. Lam Mode of progression after radioembolization in patients with colorectal cancer liver metastases EJNMMI Research Metastatic colorectal cancer Radioembolization Progression RECIST Extrahepatic metastases |
author_facet |
Caren van Roekel Jennifer M. J. Jongen Maarten L. J. Smits Sjoerd G. Elias Miriam Koopman Onno Kranenburg Inne H. M. Borel Rinkes Marnix G. E. H. Lam |
author_sort |
Caren van Roekel |
title |
Mode of progression after radioembolization in patients with colorectal cancer liver metastases |
title_short |
Mode of progression after radioembolization in patients with colorectal cancer liver metastases |
title_full |
Mode of progression after radioembolization in patients with colorectal cancer liver metastases |
title_fullStr |
Mode of progression after radioembolization in patients with colorectal cancer liver metastases |
title_full_unstemmed |
Mode of progression after radioembolization in patients with colorectal cancer liver metastases |
title_sort |
mode of progression after radioembolization in patients with colorectal cancer liver metastases |
publisher |
SpringerOpen |
series |
EJNMMI Research |
issn |
2191-219X |
publishDate |
2020-09-01 |
description |
Abstract Background Radioembolization is an established treatment modality in colorectal cancer patients with liver-dominant disease in a salvage setting. Selection of patients who will benefit most is of vital importance. The aim of this study was to assess response (and mode of progression) at 3 months after radioembolization and the impact of baseline characteristics. Methods Three months after radioembolization with either yttrium-90 resin/glass or holmium-166, anatomic response, according to RECIST 1.1, was evaluated in 90 patients. Correlations between baseline characteristics and efficacy were evaluated. For more detailed analysis of progressive disease as a dismal clinical entity, distinction was made between intra- and extrahepatic progression, and between progression of existing metastases and new metastases. Results Forty-two patients (47%) had extrahepatic disease (up to five ≥ 1 cm lung nodules, and ≤ 2 cm lymph nodes) at baseline. No patients showed complete response, 5 (5.5%) patients had partial response, 16 (17.8%) had stable disease, and 69 (76.7%) had progressive disease. Most progressive patients (67/69; 97%) had new metastases (intra-hepatic N = 11, extrahepatic N = 32; or both N = 24). Significantly fewer patients had progressive disease in the group of patients presenting without extrahepatic metastases at baseline (63% versus 93%; p = 0.0016). Median overall survival in patients with extrahepatic disease was 6.5 months, versus 10 months in patients without extrahepatic disease at baseline (hazard ratio 1.79, 95%CI 1.24–2.57). Conclusions Response at 3-month follow-up and survival were heavily influenced by new metastases. Patients with extrahepatic disease at baseline had a worse outcome compared to patients without. |
topic |
Metastatic colorectal cancer Radioembolization Progression RECIST Extrahepatic metastases |
url |
http://link.springer.com/article/10.1186/s13550-020-00697-z |
work_keys_str_mv |
AT carenvanroekel modeofprogressionafterradioembolizationinpatientswithcolorectalcancerlivermetastases AT jennifermjjongen modeofprogressionafterradioembolizationinpatientswithcolorectalcancerlivermetastases AT maartenljsmits modeofprogressionafterradioembolizationinpatientswithcolorectalcancerlivermetastases AT sjoerdgelias modeofprogressionafterradioembolizationinpatientswithcolorectalcancerlivermetastases AT miriamkoopman modeofprogressionafterradioembolizationinpatientswithcolorectalcancerlivermetastases AT onnokranenburg modeofprogressionafterradioembolizationinpatientswithcolorectalcancerlivermetastases AT innehmborelrinkes modeofprogressionafterradioembolizationinpatientswithcolorectalcancerlivermetastases AT marnixgehlam modeofprogressionafterradioembolizationinpatientswithcolorectalcancerlivermetastases |
_version_ |
1724742806974496768 |