Concentration-Dependent Binding of Small Ligands to Multiple Saturable Sites in Membrane Proteins
Abstract Membrane proteins are primary targets for most therapeutic indications in cancer and neurological diseases, binding over 50% of all known small molecule drugs. Understanding how such ligands impact membrane proteins requires knowledge on the molecular structure of ligand binding, a reasonin...
Main Authors: | Letícia Stock, Juliana Hosoume, Werner Treptow |
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Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2017-07-01
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Series: | Scientific Reports |
Online Access: | https://doi.org/10.1038/s41598-017-05896-8 |
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