Carotid Plaque Assessment Reclassifies Patients with Inflammatory Bowel Disease into Very-High Cardiovascular Risk
<b> </b>The addition of carotid ultrasound into cardiovascular (CV) risk scores has been found to be effective in identifying patients with chronic inflammatory diseases at high-CV risk. We aimed to determine if its use would facilitate the reclassification of patients with inflammatory...
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doaj-4f5d9592bd6e4d8e8a2a091e5db628982021-04-13T23:06:42ZengMDPI AGJournal of Clinical Medicine2077-03832021-04-01101671167110.3390/jcm10081671Carotid Plaque Assessment Reclassifies Patients with Inflammatory Bowel Disease into Very-High Cardiovascular RiskAlejandro Hernández-Camba0Marta Carrillo-Palau1Laura Ramos2Noemi Hernández Alvarez-Buylla3Inmaculada Alonso-Abreu4Anjara Hernández-Pérez5Milagros Vela6Laura Arranz7Manuel Hernández-Guerra8Miguel Ángel González-Gay9Iván Ferraz-Amaro10Division of Gastroenterology, Hospital Universitario de Nuestra Señora de la Candelaria, 38010 Tenerife, SpainDivision of Gastroenterology, Hospital Universitario de Canarias, 38320 Tenerife, SpainDivision of Gastroenterology, Hospital Universitario de Canarias, 38320 Tenerife, SpainDivision of Gastroenterology, Hospital Universitario de Canarias, 38320 Tenerife, SpainDivision of Gastroenterology, Hospital Universitario de Canarias, 38320 Tenerife, SpainDivision of Gastroenterology, Hospital Universitario de Canarias, 38320 Tenerife, SpainDivision of Gastroenterology, Hospital Universitario de Nuestra Señora de la Candelaria, 38010 Tenerife, SpainDivision of Gastroenterology, Hospital Universitario de Nuestra Señora de la Candelaria, 38010 Tenerife, SpainDivision of Gastroenterology, Hospital Universitario de Canarias, 38320 Tenerife, SpainDivision of Rheumatology, Hospital Universitario Marqués de Valdecilla, Universidad de Cantabria, 39008 Santander, SpainDivision of Rheumatology, Hospital Universitario de Canarias, 38320 Tenerife, Spain<b> </b>The addition of carotid ultrasound into cardiovascular (CV) risk scores has been found to be effective in identifying patients with chronic inflammatory diseases at high-CV risk. We aimed to determine if its use would facilitate the reclassification of patients with inflammatory bowel disease (IBD) into the very high-CV-risk category and whether this may be related to disease features. In this cross-sectional study encompassing 186 IBD patients and 175 controls, Systematic Coronary Risk Evaluation (SCORE), disease activity measurements, and the presence of carotid plaques by ultrasonography were assessed. Reclassification was compared between patients and controls. A multivariable regression analysis was performed to evaluate if the risk of reclassification could be explained by disease-related features and to assess the influence of traditional CV risk factors on this reclassification. After evaluation of carotid ultrasound, a significantly higher frequency of reclassification was found in patients with IBD compared to controls (35% vs. 24%, <i>p </i>=<i> </i>0.030). When this analysis was performed only on subjects included in the SCORE low-CV-risk category, 21% IBD patients compared to 11% controls (<i>p</i> = 0.034) were reclassified into the very high-CV-risk category. Disease-related data, including disease activity, were not associated with reclassification after fully multivariable regression analysis. Traditional CV risk factors showed a similar influence over reclassification in patients and controls. However, LDL-cholesterol disclosed a higher effect in controls compared to patients (beta coef. 1.03 (95%CI 1.02–1.04) vs. 1.01 (95%CI 1.00–1.02), interaction <i>p </i>=<i> </i>0.035) after adjustment for confounders. In conclusion, carotid plaque assessment is useful to identify high-CV risk IBD patients.https://www.mdpi.com/2077-0383/10/8/1671inflammatory bowel diseaseSCOREcarotid plaquescardiovascular risk |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Alejandro Hernández-Camba Marta Carrillo-Palau Laura Ramos Noemi Hernández Alvarez-Buylla Inmaculada Alonso-Abreu Anjara Hernández-Pérez Milagros Vela Laura Arranz Manuel Hernández-Guerra Miguel Ángel González-Gay Iván Ferraz-Amaro |
spellingShingle |
Alejandro Hernández-Camba Marta Carrillo-Palau Laura Ramos Noemi Hernández Alvarez-Buylla Inmaculada Alonso-Abreu Anjara Hernández-Pérez Milagros Vela Laura Arranz Manuel Hernández-Guerra Miguel Ángel González-Gay Iván Ferraz-Amaro Carotid Plaque Assessment Reclassifies Patients with Inflammatory Bowel Disease into Very-High Cardiovascular Risk Journal of Clinical Medicine inflammatory bowel disease SCORE carotid plaques cardiovascular risk |
author_facet |
Alejandro Hernández-Camba Marta Carrillo-Palau Laura Ramos Noemi Hernández Alvarez-Buylla Inmaculada Alonso-Abreu Anjara Hernández-Pérez Milagros Vela Laura Arranz Manuel Hernández-Guerra Miguel Ángel González-Gay Iván Ferraz-Amaro |
author_sort |
Alejandro Hernández-Camba |
title |
Carotid Plaque Assessment Reclassifies Patients with Inflammatory Bowel Disease into Very-High Cardiovascular Risk |
title_short |
Carotid Plaque Assessment Reclassifies Patients with Inflammatory Bowel Disease into Very-High Cardiovascular Risk |
title_full |
Carotid Plaque Assessment Reclassifies Patients with Inflammatory Bowel Disease into Very-High Cardiovascular Risk |
title_fullStr |
Carotid Plaque Assessment Reclassifies Patients with Inflammatory Bowel Disease into Very-High Cardiovascular Risk |
title_full_unstemmed |
Carotid Plaque Assessment Reclassifies Patients with Inflammatory Bowel Disease into Very-High Cardiovascular Risk |
title_sort |
carotid plaque assessment reclassifies patients with inflammatory bowel disease into very-high cardiovascular risk |
publisher |
MDPI AG |
series |
Journal of Clinical Medicine |
issn |
2077-0383 |
publishDate |
2021-04-01 |
description |
<b> </b>The addition of carotid ultrasound into cardiovascular (CV) risk scores has been found to be effective in identifying patients with chronic inflammatory diseases at high-CV risk. We aimed to determine if its use would facilitate the reclassification of patients with inflammatory bowel disease (IBD) into the very high-CV-risk category and whether this may be related to disease features. In this cross-sectional study encompassing 186 IBD patients and 175 controls, Systematic Coronary Risk Evaluation (SCORE), disease activity measurements, and the presence of carotid plaques by ultrasonography were assessed. Reclassification was compared between patients and controls. A multivariable regression analysis was performed to evaluate if the risk of reclassification could be explained by disease-related features and to assess the influence of traditional CV risk factors on this reclassification. After evaluation of carotid ultrasound, a significantly higher frequency of reclassification was found in patients with IBD compared to controls (35% vs. 24%, <i>p </i>=<i> </i>0.030). When this analysis was performed only on subjects included in the SCORE low-CV-risk category, 21% IBD patients compared to 11% controls (<i>p</i> = 0.034) were reclassified into the very high-CV-risk category. Disease-related data, including disease activity, were not associated with reclassification after fully multivariable regression analysis. Traditional CV risk factors showed a similar influence over reclassification in patients and controls. However, LDL-cholesterol disclosed a higher effect in controls compared to patients (beta coef. 1.03 (95%CI 1.02–1.04) vs. 1.01 (95%CI 1.00–1.02), interaction <i>p </i>=<i> </i>0.035) after adjustment for confounders. In conclusion, carotid plaque assessment is useful to identify high-CV risk IBD patients. |
topic |
inflammatory bowel disease SCORE carotid plaques cardiovascular risk |
url |
https://www.mdpi.com/2077-0383/10/8/1671 |
work_keys_str_mv |
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