Reactome: An integrated expert model of human molecular processes and access toolkit

• Main Authors: Bono Bernard de, Vastrik Imre, D’Eustachio Peter, Schmidt Esther, Gopinath Gopal, Croft David, Gillespie Marc, Jassal Bijay, Lewis Suzanna, Matthews Lisa, Wu Guanming, Birney Ewan, Stein Lincoln
• Format: Article
• Language: English
• Published: De Gruyter 2007-12-01
• Series: Journal of Integrative Bioinformatics
• Online Access: https://doi.org/10.1515/jib-2007-84

The behaviour of pervasive molecular processes in human biology can be studied through the large-scale modeling of the molecular events that define them. Constructing detailed models of such extent and scope is a considerable undertaking well beyond the reach and capability of individual efforts, due to the range of expertise required. Reactome (http://www.reactome.org) is an open-access project that collaborates with field experts to integrate their pathway knowledge into a single quality-checked human model. This resource dataset is systematically cross-referenced to major molecular and literature databases, and is accessible to the community in a number of well-established formats. Various tools have been developed to facilitate querying and interaction with this content. The salient features of the annotation strategy are discussed here, and examples of pathway and genomic data integration using flexible interfacing methods from the associated toolkit are also presented.