Multi-Strain Probiotics: Synergy among Isolates Enhances Biological Activities
The use of probiotics for health benefits is becoming popular because of the quest for safer products with protective and therapeutic effects against diseases and infectious agents. The emergence and spread of antimicrobial resistance among pathogens had prompted restrictions over the non-therapeuti...
Main Authors: | , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2021-04-01
|
Series: | Biology |
Subjects: | |
Online Access: | https://www.mdpi.com/2079-7737/10/4/322 |
id |
doaj-4f7cfe75a97d4741ac884cada245e25f |
---|---|
record_format |
Article |
spelling |
doaj-4f7cfe75a97d4741ac884cada245e25f2021-04-13T23:00:58ZengMDPI AGBiology2079-77372021-04-011032232210.3390/biology10040322Multi-Strain Probiotics: Synergy among Isolates Enhances Biological ActivitiesIliya D. Kwoji0Olayinka A. Aiyegoro1Moses Okpeku2Matthew A. Adeleke3Discipline of Genetics, School of Life Sciences, Westville Campus, University of KwaZulu-Natal, Durban 4000, South AfricaGastrointestinal Microbiology and Biotechnology Unit, Agricultural Research Council-Animal Production, Irene 0062, South AfricaDiscipline of Genetics, School of Life Sciences, Westville Campus, University of KwaZulu-Natal, Durban 4000, South AfricaDiscipline of Genetics, School of Life Sciences, Westville Campus, University of KwaZulu-Natal, Durban 4000, South AfricaThe use of probiotics for health benefits is becoming popular because of the quest for safer products with protective and therapeutic effects against diseases and infectious agents. The emergence and spread of antimicrobial resistance among pathogens had prompted restrictions over the non-therapeutic use of antibiotics for prophylaxis and growth promotion, especially in animal husbandry. While single-strain probiotics are beneficial to health, multi-strain probiotics might be more helpful because of synergy and additive effects among the individual isolates. This article documents the mechanisms by which multi-strain probiotics exert their effects in managing infectious and non-infectious diseases, inhibiting antibiotic-resistant pathogens and health improvement. The administration of multi-strain probiotics was revealed to effectively alleviate bowel tract conditions, such as irritable bowel syndrome, inhibition of pathogens and modulation of the immune system and gut microbiota. Finally, while most of the current research focuses on comparing the effects of multi-strain and single-strain probiotics, there is a dearth of information on the molecular mechanisms of synergy among multi-strain probiotics isolates. This forms a basis for future research in the development of multi-strain probiotics for enhanced health benefits.https://www.mdpi.com/2079-7737/10/4/322antibioticsprobioticscell-cell communicationsynergyantagonism |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Iliya D. Kwoji Olayinka A. Aiyegoro Moses Okpeku Matthew A. Adeleke |
spellingShingle |
Iliya D. Kwoji Olayinka A. Aiyegoro Moses Okpeku Matthew A. Adeleke Multi-Strain Probiotics: Synergy among Isolates Enhances Biological Activities Biology antibiotics probiotics cell-cell communication synergy antagonism |
author_facet |
Iliya D. Kwoji Olayinka A. Aiyegoro Moses Okpeku Matthew A. Adeleke |
author_sort |
Iliya D. Kwoji |
title |
Multi-Strain Probiotics: Synergy among Isolates Enhances Biological Activities |
title_short |
Multi-Strain Probiotics: Synergy among Isolates Enhances Biological Activities |
title_full |
Multi-Strain Probiotics: Synergy among Isolates Enhances Biological Activities |
title_fullStr |
Multi-Strain Probiotics: Synergy among Isolates Enhances Biological Activities |
title_full_unstemmed |
Multi-Strain Probiotics: Synergy among Isolates Enhances Biological Activities |
title_sort |
multi-strain probiotics: synergy among isolates enhances biological activities |
publisher |
MDPI AG |
series |
Biology |
issn |
2079-7737 |
publishDate |
2021-04-01 |
description |
The use of probiotics for health benefits is becoming popular because of the quest for safer products with protective and therapeutic effects against diseases and infectious agents. The emergence and spread of antimicrobial resistance among pathogens had prompted restrictions over the non-therapeutic use of antibiotics for prophylaxis and growth promotion, especially in animal husbandry. While single-strain probiotics are beneficial to health, multi-strain probiotics might be more helpful because of synergy and additive effects among the individual isolates. This article documents the mechanisms by which multi-strain probiotics exert their effects in managing infectious and non-infectious diseases, inhibiting antibiotic-resistant pathogens and health improvement. The administration of multi-strain probiotics was revealed to effectively alleviate bowel tract conditions, such as irritable bowel syndrome, inhibition of pathogens and modulation of the immune system and gut microbiota. Finally, while most of the current research focuses on comparing the effects of multi-strain and single-strain probiotics, there is a dearth of information on the molecular mechanisms of synergy among multi-strain probiotics isolates. This forms a basis for future research in the development of multi-strain probiotics for enhanced health benefits. |
topic |
antibiotics probiotics cell-cell communication synergy antagonism |
url |
https://www.mdpi.com/2079-7737/10/4/322 |
work_keys_str_mv |
AT iliyadkwoji multistrainprobioticssynergyamongisolatesenhancesbiologicalactivities AT olayinkaaaiyegoro multistrainprobioticssynergyamongisolatesenhancesbiologicalactivities AT mosesokpeku multistrainprobioticssynergyamongisolatesenhancesbiologicalactivities AT matthewaadeleke multistrainprobioticssynergyamongisolatesenhancesbiologicalactivities |
_version_ |
1721528446100701184 |