Primary Intra-Osseous Liposarcoma of the Femur: A Case Report
We report a rare case of an intra-osseous liposarcoma of the proximal femur. A 26-year-old man presented with a 6-month history of left groin pain radiating to the knee and an antalgic gait. Radiology showed a predominantly fatty lesion in the medial aspect of the femoral neck extending toward the l...
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2009-12-01
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Series: | Journal of Orthopaedic Surgery |
Online Access: | https://doi.org/10.1177/230949900901700327 |
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doaj-4f7ef4ea883c432eafe66807e0066ce32020-11-25T03:16:57ZengSAGE PublishingJournal of Orthopaedic Surgery2309-49902009-12-011710.1177/230949900901700327Primary Intra-Osseous Liposarcoma of the Femur: A Case ReportSimon MacmullHenry Dushan Edward AtkinsonSrdjan SasoRoberto TiraboscoPaul O'DonnellJohn Andrew SkinnerWe report a rare case of an intra-osseous liposarcoma of the proximal femur. A 26-year-old man presented with a 6-month history of left groin pain radiating to the knee and an antalgic gait. Radiology showed a predominantly fatty lesion in the medial aspect of the femoral neck extending toward the lesser trochanter; most of the marrow in the femoral neck had been replaced without evidence of an extra-osseous mass; and the posterior cortex had been destroyed. Histological and immunohistochemical analyses of the tumour after open biopsy were indicative of high-grade liposarcomatous malignancy. After exclusion of any other primary tumour foci or metastases on regional and whole-body magnetic resonance images, the diagnosis of a high-grade intra-osseous primary liposarcoma of the proximal femur was made. The patient received 2 preoperative courses of neoadjuvant doxorubicin, cisplatin and methotrexate. After proximal femoral replacement following en bloc excision of the proximal femur, 4 more cycles of adjuvant ifosfamide and etoposide were given. At the 16-month follow-up, he remained independently ambulatory, with no local or distant recurrence. Tissue diagnosis and multimodal imaging, rather than any single radiological investigation, are important in making the diagnosis.https://doi.org/10.1177/230949900901700327 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Simon Macmull Henry Dushan Edward Atkinson Srdjan Saso Roberto Tirabosco Paul O'Donnell John Andrew Skinner |
spellingShingle |
Simon Macmull Henry Dushan Edward Atkinson Srdjan Saso Roberto Tirabosco Paul O'Donnell John Andrew Skinner Primary Intra-Osseous Liposarcoma of the Femur: A Case Report Journal of Orthopaedic Surgery |
author_facet |
Simon Macmull Henry Dushan Edward Atkinson Srdjan Saso Roberto Tirabosco Paul O'Donnell John Andrew Skinner |
author_sort |
Simon Macmull |
title |
Primary Intra-Osseous Liposarcoma of the Femur: A Case Report |
title_short |
Primary Intra-Osseous Liposarcoma of the Femur: A Case Report |
title_full |
Primary Intra-Osseous Liposarcoma of the Femur: A Case Report |
title_fullStr |
Primary Intra-Osseous Liposarcoma of the Femur: A Case Report |
title_full_unstemmed |
Primary Intra-Osseous Liposarcoma of the Femur: A Case Report |
title_sort |
primary intra-osseous liposarcoma of the femur: a case report |
publisher |
SAGE Publishing |
series |
Journal of Orthopaedic Surgery |
issn |
2309-4990 |
publishDate |
2009-12-01 |
description |
We report a rare case of an intra-osseous liposarcoma of the proximal femur. A 26-year-old man presented with a 6-month history of left groin pain radiating to the knee and an antalgic gait. Radiology showed a predominantly fatty lesion in the medial aspect of the femoral neck extending toward the lesser trochanter; most of the marrow in the femoral neck had been replaced without evidence of an extra-osseous mass; and the posterior cortex had been destroyed. Histological and immunohistochemical analyses of the tumour after open biopsy were indicative of high-grade liposarcomatous malignancy. After exclusion of any other primary tumour foci or metastases on regional and whole-body magnetic resonance images, the diagnosis of a high-grade intra-osseous primary liposarcoma of the proximal femur was made. The patient received 2 preoperative courses of neoadjuvant doxorubicin, cisplatin and methotrexate. After proximal femoral replacement following en bloc excision of the proximal femur, 4 more cycles of adjuvant ifosfamide and etoposide were given. At the 16-month follow-up, he remained independently ambulatory, with no local or distant recurrence. Tissue diagnosis and multimodal imaging, rather than any single radiological investigation, are important in making the diagnosis. |
url |
https://doi.org/10.1177/230949900901700327 |
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