Notch signaling deficiency underlies age-dependent depletion of satellite cells in muscular dystrophy

Notch signaling deficiency underlies age-dependent depletion of satellite cells in muscular dystrophy

Duchenne muscular dystrophy (DMD) is a devastating disease characterized by muscle wasting, loss of mobility and death in early adulthood. Satellite cells are muscle-resident stem cells responsible for the repair and regeneration of damaged muscles. One pathological feature of DMD is the progressive...

Full description

Bibliographic Details
Main Authors: Chunhui Jiang, Yefei Wen, Kazuki Kuroda, Kevin Hannon, Michael A. Rudnicki, Shihuan Kuang
Format: Article
Language:English
Published: The Company of Biologists 2014-08-01
Series:Disease Models & Mechanisms
Subjects:
Muscular dystrophy
Notch signaling
Stem cell
Online Access:http://dmm.biologists.org/content/7/8/997

Internet

http://dmm.biologists.org/content/7/8/997

Similar Items