Young athletes: Preventing sudden death by adopting a modern screening approach? A critical review and the opening of a debate
Preventing sudden cardiac death (SCD) in athletes is a primary duty of sports cardiologists. Current recommendations for detecting high-risk cardiovascular conditions (hr-CVCs) are history and physical examination (H&P)-based. We discuss the effectiveness of H&P-based screening versus more-m...
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Format: | Article |
Language: | English |
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Elsevier
2021-06-01
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Series: | International Journal of Cardiology: Heart & Vasculature |
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Online Access: | http://www.sciencedirect.com/science/article/pii/S2352906721000786 |
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Article |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Paolo Angelini Raja Muthupillai Alberto Lopez Benjamin Cheong Carlo Uribe Eduardo Hernandez Stephanie Coulter Emerson Perin Silvana Molossi Federico Gentile Scott Flamm Giovanni Lorenz Flavio D'Ascenzi Jonathan Tobis Roberto Sarnari Antonio Corno James Furgerson Amedeo Chiribiri Adriana D.M. Villa Fulvio Orzan Pedro Brugada John Jefferies Pierre Aubry Jeffrey Towbin Gaetano Thiene Robert Tomanek |
spellingShingle |
Paolo Angelini Raja Muthupillai Alberto Lopez Benjamin Cheong Carlo Uribe Eduardo Hernandez Stephanie Coulter Emerson Perin Silvana Molossi Federico Gentile Scott Flamm Giovanni Lorenz Flavio D'Ascenzi Jonathan Tobis Roberto Sarnari Antonio Corno James Furgerson Amedeo Chiribiri Adriana D.M. Villa Fulvio Orzan Pedro Brugada John Jefferies Pierre Aubry Jeffrey Towbin Gaetano Thiene Robert Tomanek Young athletes: Preventing sudden death by adopting a modern screening approach? A critical review and the opening of a debate International Journal of Cardiology: Heart & Vasculature Death, sudden, cardiac Heart defects, congenital Sports medicine Adolescent medicine Autopsy Diagnostic screening programs |
author_facet |
Paolo Angelini Raja Muthupillai Alberto Lopez Benjamin Cheong Carlo Uribe Eduardo Hernandez Stephanie Coulter Emerson Perin Silvana Molossi Federico Gentile Scott Flamm Giovanni Lorenz Flavio D'Ascenzi Jonathan Tobis Roberto Sarnari Antonio Corno James Furgerson Amedeo Chiribiri Adriana D.M. Villa Fulvio Orzan Pedro Brugada John Jefferies Pierre Aubry Jeffrey Towbin Gaetano Thiene Robert Tomanek |
author_sort |
Paolo Angelini |
title |
Young athletes: Preventing sudden death by adopting a modern screening approach? A critical review and the opening of a debate |
title_short |
Young athletes: Preventing sudden death by adopting a modern screening approach? A critical review and the opening of a debate |
title_full |
Young athletes: Preventing sudden death by adopting a modern screening approach? A critical review and the opening of a debate |
title_fullStr |
Young athletes: Preventing sudden death by adopting a modern screening approach? A critical review and the opening of a debate |
title_full_unstemmed |
Young athletes: Preventing sudden death by adopting a modern screening approach? A critical review and the opening of a debate |
title_sort |
young athletes: preventing sudden death by adopting a modern screening approach? a critical review and the opening of a debate |
publisher |
Elsevier |
series |
International Journal of Cardiology: Heart & Vasculature |
issn |
2352-9067 |
publishDate |
2021-06-01 |
description |
Preventing sudden cardiac death (SCD) in athletes is a primary duty of sports cardiologists. Current recommendations for detecting high-risk cardiovascular conditions (hr-CVCs) are history and physical examination (H&P)-based. We discuss the effectiveness of H&P-based screening versus more-modern and accurate methods. In this position paper, we review current authoritative statements and suggest a novel alternative: screening MRI (s-MRI), supported by evidence from a preliminary population-based study (completed in 2018), and a prospective, controlled study in military recruits (in development).We present: 1. Literature-Based Comparisons (for diagnosing hr-CVCs): Two recent studies using traditional methods to identify hr-CVCs in >3,000 young athletes are compared with our s-MRI-based study of 5,169 adolescents. 2. Critical Review of Previous Results: The reported incidence of SCD in athletes is presently based on retrospective, observational, and incomplete studies. H&P’s screening value seems minimal for structural heart disease, versus echocardiography (which improves diagnosis for high-risk cardiomyopathies) and s-MRI (which also identifies high-risk coronary artery anomalies). Electrocardiography is valuable in screening for potentially high-risk electrophysiological anomalies. 3. Proposed Project: We propose a prospective, controlled study (2 comparable large cohorts: one historical, one prospective) to compare: (1) diagnostic accuracy and resulting mortality-prevention performance of traditional screening methods versus questionnaire/electrocardiography/s-MRI, during 2-month periods of intense, structured exercise (in military recruits, in advanced state of preparation); (2) global costs and cost/efficiency between these two methods. This study should contribute significantly toward a comprehensive understanding of the incidence and causes of exercise-related mortality (including establishing a definition of hr-CVCs) while aiming to reduce mortality. |
topic |
Death, sudden, cardiac Heart defects, congenital Sports medicine Adolescent medicine Autopsy Diagnostic screening programs |
url |
http://www.sciencedirect.com/science/article/pii/S2352906721000786 |
work_keys_str_mv |
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doaj-4f98b893b46e42749d7e51e8478c55512021-06-29T04:12:56ZengElsevierInternational Journal of Cardiology: Heart & Vasculature2352-90672021-06-0134100790Young athletes: Preventing sudden death by adopting a modern screening approach? A critical review and the opening of a debatePaolo Angelini0Raja Muthupillai1Alberto Lopez2Benjamin Cheong3Carlo Uribe4Eduardo Hernandez5Stephanie Coulter6Emerson Perin7Silvana Molossi8Federico Gentile9Scott Flamm10Giovanni Lorenz11Flavio D'Ascenzi12Jonathan Tobis13Roberto Sarnari14Antonio Corno15James Furgerson16Amedeo Chiribiri17Adriana D.M. Villa18Fulvio Orzan19Pedro Brugada20John Jefferies21Pierre Aubry22Jeffrey Towbin23Gaetano Thiene24Robert Tomanek25Department of Cardiology, Texas Heart Institute, Houston, TX, USA; Corresponding author at: Department of Cardiology, Texas Heart Institute, 6624 Fannin Street, Suite 2780, Houston, TX 77030, USA.Department of Radiology, University of Houston, Houston, TX, USAElectrophysiology Laboratory, Department of Cardiology, Texas Heart Institute, Houston, TX, USADepartment of Radiology, Texas Heart Institute, Houston, TX, USADepartment of Cardiology, Texas Heart Institute, Houston, TX, USADepartment of Cardiology, Texas Heart Institute, Houston, TX, USADepartment of Cardiology, Texas Heart Institute, Houston, TX, USADepartment of Cardiology, Texas Heart Institute, Houston, TX, USASection of Pediatric Cardiology, Department of Pediatrics, Texas Children’s Hospital, Baylor College of Medicine, Houston, TX, United StatesCentro Cardiologico Gentile, Naples, ItalyDepartment of Radiology, Cleveland Clinic, Cleveland, OH, USADepartment of Radiology, Wilford Hall Ambulatory Center, San Antonio Military Health System, Joint Base San Antonio, San Antonio, TX, USADivision of Cardiology, University of Siena, Siena, ItalyDepartment of Cardiology, University of California Los Angeles, Los Angeles, CA, USADepartment of Radiology, Northwestern University, Chicago, IL, USADepartment of Congenital Cardiac Surgery, Children’s Memorial Hermann Hospital, UTHealth, Houston, TX, USADepartment of Cardio-Radiology, US Air Force Lackland Hospital, San Antonio, TX, USADepartment of Cardiovascular Imaging, School of Biomedical Engineering and Imaging Sciences, King’s College London, United KingdomDepartment of Radiology, St. Thomas Hospital, King’s College London, United KingdomDivision of Cardiology, Department of Medical Sciences, University of Turin, ItalyCardiovascular Division, Free University of Brussels (UZ Brussel) VUB, Brussels, BelgiumThe Cardiac Institute, University of Tennessee Health Science Center, Memphis, TN, USADepartment of Cardiology, Bichat Hospital, Paris, FranceDivision of Adult Cardiovascular Diseases, Methodist University of Tennessee Cardiovascular Institute and Department of Preventive Medicine, St Jude Children’s Research Hospital, Memphis, TN, USADepartment of Pathologic Anatomy, University of Padua, ItalyDepartment of Anatomy and Cell Biology, University of Iowa, Iowa City, IA, USAPreventing sudden cardiac death (SCD) in athletes is a primary duty of sports cardiologists. Current recommendations for detecting high-risk cardiovascular conditions (hr-CVCs) are history and physical examination (H&P)-based. We discuss the effectiveness of H&P-based screening versus more-modern and accurate methods. In this position paper, we review current authoritative statements and suggest a novel alternative: screening MRI (s-MRI), supported by evidence from a preliminary population-based study (completed in 2018), and a prospective, controlled study in military recruits (in development).We present: 1. Literature-Based Comparisons (for diagnosing hr-CVCs): Two recent studies using traditional methods to identify hr-CVCs in >3,000 young athletes are compared with our s-MRI-based study of 5,169 adolescents. 2. Critical Review of Previous Results: The reported incidence of SCD in athletes is presently based on retrospective, observational, and incomplete studies. H&P’s screening value seems minimal for structural heart disease, versus echocardiography (which improves diagnosis for high-risk cardiomyopathies) and s-MRI (which also identifies high-risk coronary artery anomalies). Electrocardiography is valuable in screening for potentially high-risk electrophysiological anomalies. 3. Proposed Project: We propose a prospective, controlled study (2 comparable large cohorts: one historical, one prospective) to compare: (1) diagnostic accuracy and resulting mortality-prevention performance of traditional screening methods versus questionnaire/electrocardiography/s-MRI, during 2-month periods of intense, structured exercise (in military recruits, in advanced state of preparation); (2) global costs and cost/efficiency between these two methods. This study should contribute significantly toward a comprehensive understanding of the incidence and causes of exercise-related mortality (including establishing a definition of hr-CVCs) while aiming to reduce mortality.http://www.sciencedirect.com/science/article/pii/S2352906721000786Death, sudden, cardiacHeart defects, congenitalSports medicineAdolescent medicineAutopsyDiagnostic screening programs |