Jujuboside B Inhibits the Proliferation of Breast Cancer Cell Lines by Inducing Apoptosis and Autophagy
Jujuboside B (JB) is one of the main biologically active ingredients extracted from Zizyphi Spinosi Semen (ZSS), a widely used traditional Chinese medicine for treating insomnia and anxiety. Breast cancer is the most common cancer and the second leading cause of cancer-related death in women worldwi...
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doaj-4f9b7fea02df494ab7ed803017fab99e2021-09-24T06:05:30ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122021-09-011210.3389/fphar.2021.668887668887Jujuboside B Inhibits the Proliferation of Breast Cancer Cell Lines by Inducing Apoptosis and AutophagyLin Guo0Lin Guo1Yupei Liang2Shiwen Wang3Lihui Li4Lili Cai5Yongqing Heng6Jing Yang7Xing Jin8Junqian Zhang9Shuying Yuan10Tong Xu11Lijun Jia12Lijun Jia13Cancer Institute, Fudan University Shanghai Cancer Center, Fudan University, Shanghai, ChinaDepartment of Immunology, School of Basic Medical Sciences, Fudan University, Shanghai, ChinaCancer Institute, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaDepartment of Laboratory Medicine, Huadong Hospital Affiliated to Fudan University, Shanghai, ChinaCancer Institute, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaCancer Institute, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaCancer Institute, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaCancer Institute, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaCancer Institute, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaCancer Institute, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaCancer Institute, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaCancer Institute, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaCancer Institute, Fudan University Shanghai Cancer Center, Fudan University, Shanghai, ChinaCancer Institute, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaJujuboside B (JB) is one of the main biologically active ingredients extracted from Zizyphi Spinosi Semen (ZSS), a widely used traditional Chinese medicine for treating insomnia and anxiety. Breast cancer is the most common cancer and the second leading cause of cancer-related death in women worldwide. The purpose of this study was to examine whether JB could prevent breast cancer and its underlying mechanism. First, we reported that JB induced apoptosis and autophagy in MDA-MB-231 and MCF-7 human breast cancer cell lines. Further mechanistic studies have revealed that JB-induced apoptosis was mediated by NOXA in both two cell lines. Moreover, the AMPK signaling pathway plays an important role in JB-induced autophagy in MCF-7. To confirm the anti-breast cancer effect of JB, the interaction of JB-induced apoptosis and autophagy was investigated by both pharmacological and genetic approaches. Results indicated that autophagy played a pro-survival role in attenuating apoptosis. Further in vivo study showed that JB significantly suppressed the growth of MDA-MB-231 and MCF-7 xenografts. In conclusion, our findings indicate that JB exerts its anti-breast cancer effect in association with the induction of apoptosis and autophagy.https://www.frontiersin.org/articles/10.3389/fphar.2021.668887/fulljujuboside Bbreast cancerapoptosisautophagyNOXAAMPK |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Lin Guo Lin Guo Yupei Liang Shiwen Wang Lihui Li Lili Cai Yongqing Heng Jing Yang Xing Jin Junqian Zhang Shuying Yuan Tong Xu Lijun Jia Lijun Jia |
spellingShingle |
Lin Guo Lin Guo Yupei Liang Shiwen Wang Lihui Li Lili Cai Yongqing Heng Jing Yang Xing Jin Junqian Zhang Shuying Yuan Tong Xu Lijun Jia Lijun Jia Jujuboside B Inhibits the Proliferation of Breast Cancer Cell Lines by Inducing Apoptosis and Autophagy Frontiers in Pharmacology jujuboside B breast cancer apoptosis autophagy NOXA AMPK |
author_facet |
Lin Guo Lin Guo Yupei Liang Shiwen Wang Lihui Li Lili Cai Yongqing Heng Jing Yang Xing Jin Junqian Zhang Shuying Yuan Tong Xu Lijun Jia Lijun Jia |
author_sort |
Lin Guo |
title |
Jujuboside B Inhibits the Proliferation of Breast Cancer Cell Lines by Inducing Apoptosis and Autophagy |
title_short |
Jujuboside B Inhibits the Proliferation of Breast Cancer Cell Lines by Inducing Apoptosis and Autophagy |
title_full |
Jujuboside B Inhibits the Proliferation of Breast Cancer Cell Lines by Inducing Apoptosis and Autophagy |
title_fullStr |
Jujuboside B Inhibits the Proliferation of Breast Cancer Cell Lines by Inducing Apoptosis and Autophagy |
title_full_unstemmed |
Jujuboside B Inhibits the Proliferation of Breast Cancer Cell Lines by Inducing Apoptosis and Autophagy |
title_sort |
jujuboside b inhibits the proliferation of breast cancer cell lines by inducing apoptosis and autophagy |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Pharmacology |
issn |
1663-9812 |
publishDate |
2021-09-01 |
description |
Jujuboside B (JB) is one of the main biologically active ingredients extracted from Zizyphi Spinosi Semen (ZSS), a widely used traditional Chinese medicine for treating insomnia and anxiety. Breast cancer is the most common cancer and the second leading cause of cancer-related death in women worldwide. The purpose of this study was to examine whether JB could prevent breast cancer and its underlying mechanism. First, we reported that JB induced apoptosis and autophagy in MDA-MB-231 and MCF-7 human breast cancer cell lines. Further mechanistic studies have revealed that JB-induced apoptosis was mediated by NOXA in both two cell lines. Moreover, the AMPK signaling pathway plays an important role in JB-induced autophagy in MCF-7. To confirm the anti-breast cancer effect of JB, the interaction of JB-induced apoptosis and autophagy was investigated by both pharmacological and genetic approaches. Results indicated that autophagy played a pro-survival role in attenuating apoptosis. Further in vivo study showed that JB significantly suppressed the growth of MDA-MB-231 and MCF-7 xenografts. In conclusion, our findings indicate that JB exerts its anti-breast cancer effect in association with the induction of apoptosis and autophagy. |
topic |
jujuboside B breast cancer apoptosis autophagy NOXA AMPK |
url |
https://www.frontiersin.org/articles/10.3389/fphar.2021.668887/full |
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