Photoswitchable precision glycooligomers and their lectin binding

The synthesis of photoswitchable glycooligomers is presented by applying solid-phase polymer synthesis and functional building blocks. The obtained glycoligands are monodisperse and present azobenzene moieties as well as sugar ligands at defined positions within the oligomeric backbone and side chai...

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Main Authors:	Daniela Ponader, Sinaida Igde, Marko Wehle, Katharina Märker, Mark Santer, David Bléger, Laura Hartmann
Format:	Article
Language:	English
Published:	Beilstein-Institut 2014-07-01
Series:	Beilstein Journal of Organic Chemistry
Subjects:	azobenzene glycopolymer lectin binding multivalency multivalent glycosystems photoswitch precision polymer
Online Access:	https://doi.org/10.3762/bjoc.10.166

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spelling	doaj-4f9e4e3faf304e0081c2e467c0e1c5e02021-04-02T15:33:03ZengBeilstein-InstitutBeilstein Journal of Organic Chemistry1860-53972014-07-011011603161210.3762/bjoc.10.1661860-5397-10-166Photoswitchable precision glycooligomers and their lectin bindingDaniela Ponader0Sinaida Igde1Marko Wehle2Katharina Märker3Mark Santer4David Bléger5Laura Hartmann6Max Planck Institute of Colloids and Interfaces, Department of Biomolecular Systems, Research Campus Golm, 14424 Potsdam, GermanyMax Planck Institute of Colloids and Interfaces, Department of Biomolecular Systems, Research Campus Golm, 14424 Potsdam, GermanyMax Planck Institute of Colloids and Interfaces, Department of Theory & Bio-Systems, Research Campus Golm, 14424 Potsdam, GermanyMax Planck Institute of Colloids and Interfaces, Department of Biomolecular Systems, Research Campus Golm, 14424 Potsdam, GermanyMax Planck Institute of Colloids and Interfaces, Department of Theory & Bio-Systems, Research Campus Golm, 14424 Potsdam, GermanyHumboldt University, Department of Chemistry, Brook-Taylor-Str. 2, 12489 Berlin, GermanyMax Planck Institute of Colloids and Interfaces, Department of Biomolecular Systems, Research Campus Golm, 14424 Potsdam, GermanyThe synthesis of photoswitchable glycooligomers is presented by applying solid-phase polymer synthesis and functional building blocks. The obtained glycoligands are monodisperse and present azobenzene moieties as well as sugar ligands at defined positions within the oligomeric backbone and side chains, respectively. We show that the combination of molecular precision together with the photoswitchable properties of the azobenzene unit allows for the photosensitive control of glycoligand binding to protein receptors. These stimuli-sensitive glycoligands promote the understanding of multivalent binding and will be further developed as novel biosensors.https://doi.org/10.3762/bjoc.10.166azobenzeneglycopolymerlectin bindingmultivalencymultivalent glycosystemsphotoswitchprecision polymer
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Daniela Ponader Sinaida Igde Marko Wehle Katharina Märker Mark Santer David Bléger Laura Hartmann
spellingShingle	Daniela Ponader Sinaida Igde Marko Wehle Katharina Märker Mark Santer David Bléger Laura Hartmann Photoswitchable precision glycooligomers and their lectin binding Beilstein Journal of Organic Chemistry azobenzene glycopolymer lectin binding multivalency multivalent glycosystems photoswitch precision polymer
author_facet	Daniela Ponader Sinaida Igde Marko Wehle Katharina Märker Mark Santer David Bléger Laura Hartmann
author_sort	Daniela Ponader
title	Photoswitchable precision glycooligomers and their lectin binding
title_short	Photoswitchable precision glycooligomers and their lectin binding
title_full	Photoswitchable precision glycooligomers and their lectin binding
title_fullStr	Photoswitchable precision glycooligomers and their lectin binding
title_full_unstemmed	Photoswitchable precision glycooligomers and their lectin binding
title_sort	photoswitchable precision glycooligomers and their lectin binding
publisher	Beilstein-Institut
series	Beilstein Journal of Organic Chemistry
issn	1860-5397
publishDate	2014-07-01
description	The synthesis of photoswitchable glycooligomers is presented by applying solid-phase polymer synthesis and functional building blocks. The obtained glycoligands are monodisperse and present azobenzene moieties as well as sugar ligands at defined positions within the oligomeric backbone and side chains, respectively. We show that the combination of molecular precision together with the photoswitchable properties of the azobenzene unit allows for the photosensitive control of glycoligand binding to protein receptors. These stimuli-sensitive glycoligands promote the understanding of multivalent binding and will be further developed as novel biosensors.
topic	azobenzene glycopolymer lectin binding multivalency multivalent glycosystems photoswitch precision polymer
url	https://doi.org/10.3762/bjoc.10.166
work_keys_str_mv	AT danielaponader photoswitchableprecisionglycooligomersandtheirlectinbinding AT sinaidaigde photoswitchableprecisionglycooligomersandtheirlectinbinding AT markowehle photoswitchableprecisionglycooligomersandtheirlectinbinding AT katharinamarker photoswitchableprecisionglycooligomersandtheirlectinbinding AT marksanter photoswitchableprecisionglycooligomersandtheirlectinbinding AT davidbleger photoswitchableprecisionglycooligomersandtheirlectinbinding AT laurahartmann photoswitchableprecisionglycooligomersandtheirlectinbinding
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Photoswitchable precision glycooligomers and their lectin binding

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