Alteration of Diffusion Capacity After SARS-CoV-2 Infection: A Pathophysiological Approach

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has affected millions of people worldwide, and pneumonia affects 90% of patients. This raises the possibility of millions of people with altered lung function. Few data exist to date on pulmonary function after SARS-CoV-2 infecti...

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Main Authors:	Justine Frija-Masson, Catherine Bancal, Laurent Plantier, Hélène Benzaquen, Laurence Mangin, Dominique Penaud, Florence Arnoult, Martin Flamant, Marie-Pia d’Ortho
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2021-03-01
Series:	Frontiers in Physiology
Subjects:	SARS-CoV-2 DLCO pneumonia pulmonary function test COVID-19
Online Access:	https://www.frontiersin.org/articles/10.3389/fphys.2021.624062/full

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spelling	doaj-4fa611c543014a6cb16212208b345f2a2021-03-25T15:22:01ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2021-03-011210.3389/fphys.2021.624062624062Alteration of Diffusion Capacity After SARS-CoV-2 Infection: A Pathophysiological ApproachJustine Frija-Masson0Justine Frija-Masson1Catherine Bancal2Laurent Plantier3Laurent Plantier4Hélène Benzaquen5Laurence Mangin6Laurence Mangin7Dominique Penaud8Florence Arnoult9Martin Flamant10Martin Flamant11Marie-Pia d’Ortho12Marie-Pia d’Ortho13Neurodiderot, INSERM, Université de Paris, Paris, FrancePhysiologie-Explorations Fonctionnelles, FHU APOLLO, Assistance Publique Hôpitaux de Paris, Hôpital Bichat-Claude Bernard, Paris, FrancePhysiologie-Explorations Fonctionnelles, FHU APOLLO, Assistance Publique Hôpitaux de Paris, Hôpital Bichat-Claude Bernard, Paris, FranceCentre de Ressources et de Compétences de la Mucoviscidose, Service de Pneumologie et Explorations Fonctionnelles Respiratoires, CHRU de Tours, Tours, FranceCEPR/INSERM, UMR 1100, Université de Tours, Tours, FrancePhysiologie-Explorations Fonctionnelles, FHU APOLLO, Assistance Publique Hôpitaux de Paris, Hôpital Bichat-Claude Bernard, Paris, FrancePhysiologie-Explorations Fonctionnelles, FHU APOLLO, Assistance Publique Hôpitaux de Paris, Hôpital Bichat-Claude Bernard, Paris, FranceLaboratoire Matière et Systèmes Complexes, UMR 7505, CNRS, Paris, FrancePhysiologie-Explorations Fonctionnelles, FHU APOLLO, Assistance Publique Hôpitaux de Paris, Hôpital Bichat-Claude Bernard, Paris, FrancePhysiologie-Explorations Fonctionnelles, FHU APOLLO, Assistance Publique Hôpitaux de Paris, Hôpital Bichat-Claude Bernard, Paris, FrancePhysiologie-Explorations Fonctionnelles, FHU APOLLO, Assistance Publique Hôpitaux de Paris, Hôpital Bichat-Claude Bernard, Paris, FranceINSERM U 1149, Center for Research in Inflammation, Université de Paris, Paris, FranceNeurodiderot, INSERM, Université de Paris, Paris, FrancePhysiologie-Explorations Fonctionnelles, FHU APOLLO, Assistance Publique Hôpitaux de Paris, Hôpital Bichat-Claude Bernard, Paris, FranceSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has affected millions of people worldwide, and pneumonia affects 90% of patients. This raises the possibility of millions of people with altered lung function. Few data exist to date on pulmonary function after SARS-CoV-2 infection, but alteration of diffusion capacity of CO (DLCO) is the most frequently described abnormality. First, we present original data on lung function at 3 months after SARS-CoV-2 infection and discuss the effect of using European Coal and Steel Community (ECSC) or Global Lung Function Initiative (GLI) reference equations to diagnose diffusion capacity. Second, we review existing data on DLCO alteration after SARS-CoV-2 infection and discuss the implication of restrictive disorder in DLCO alteration. Last, we discuss the pathophysiology of DLCO alteration and try to disentangle vascular damage and fibrosis.https://www.frontiersin.org/articles/10.3389/fphys.2021.624062/fullSARS-CoV-2DLCOpneumoniapulmonary function testCOVID-19
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Justine Frija-Masson Justine Frija-Masson Catherine Bancal Laurent Plantier Laurent Plantier Hélène Benzaquen Laurence Mangin Laurence Mangin Dominique Penaud Florence Arnoult Martin Flamant Martin Flamant Marie-Pia d’Ortho Marie-Pia d’Ortho
spellingShingle	Justine Frija-Masson Justine Frija-Masson Catherine Bancal Laurent Plantier Laurent Plantier Hélène Benzaquen Laurence Mangin Laurence Mangin Dominique Penaud Florence Arnoult Martin Flamant Martin Flamant Marie-Pia d’Ortho Marie-Pia d’Ortho Alteration of Diffusion Capacity After SARS-CoV-2 Infection: A Pathophysiological Approach Frontiers in Physiology SARS-CoV-2 DLCO pneumonia pulmonary function test COVID-19
author_facet	Justine Frija-Masson Justine Frija-Masson Catherine Bancal Laurent Plantier Laurent Plantier Hélène Benzaquen Laurence Mangin Laurence Mangin Dominique Penaud Florence Arnoult Martin Flamant Martin Flamant Marie-Pia d’Ortho Marie-Pia d’Ortho
author_sort	Justine Frija-Masson
title	Alteration of Diffusion Capacity After SARS-CoV-2 Infection: A Pathophysiological Approach
title_short	Alteration of Diffusion Capacity After SARS-CoV-2 Infection: A Pathophysiological Approach
title_full	Alteration of Diffusion Capacity After SARS-CoV-2 Infection: A Pathophysiological Approach
title_fullStr	Alteration of Diffusion Capacity After SARS-CoV-2 Infection: A Pathophysiological Approach
title_full_unstemmed	Alteration of Diffusion Capacity After SARS-CoV-2 Infection: A Pathophysiological Approach
title_sort	alteration of diffusion capacity after sars-cov-2 infection: a pathophysiological approach
publisher	Frontiers Media S.A.
series	Frontiers in Physiology
issn	1664-042X
publishDate	2021-03-01
description	Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has affected millions of people worldwide, and pneumonia affects 90% of patients. This raises the possibility of millions of people with altered lung function. Few data exist to date on pulmonary function after SARS-CoV-2 infection, but alteration of diffusion capacity of CO (DLCO) is the most frequently described abnormality. First, we present original data on lung function at 3 months after SARS-CoV-2 infection and discuss the effect of using European Coal and Steel Community (ECSC) or Global Lung Function Initiative (GLI) reference equations to diagnose diffusion capacity. Second, we review existing data on DLCO alteration after SARS-CoV-2 infection and discuss the implication of restrictive disorder in DLCO alteration. Last, we discuss the pathophysiology of DLCO alteration and try to disentangle vascular damage and fibrosis.
topic	SARS-CoV-2 DLCO pneumonia pulmonary function test COVID-19
url	https://www.frontiersin.org/articles/10.3389/fphys.2021.624062/full
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Alteration of Diffusion Capacity After SARS-CoV-2 Infection: A Pathophysiological Approach

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