Immunostimulatory Phosphatidylmonogalactosyldiacylglycerols (PGDG) from the Marine Diatom <i>Thalassiosira weissflogii</i>: Inspiration for a Novel Synthetic Toll-Like Receptor 4 Agonist

Immunostimulatory Phosphatidylmonogalactosyldiacylglycerols (PGDG) from the Marine Diatom <i>Thalassiosira weissflogii</i>: Inspiration for a Novel Synthetic Toll-Like Receptor 4 Agonist

An unprecedented phosphatidylmonogalactosyldiacylglycerol pool (PGDG, <b>1</b>) rich in polyunsaturated fatty acids was isolated from the marine diatoms <i>Thalassiosira weissflogii</i>. Here we report for the first time the NMR characterization of this rare lipid from marine...

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Bibliographic Details
Main Authors: Emiliano Manzo, Carmela Gallo, Rossella Sartorius, Genoveffa Nuzzo, Angela Sardo, Piergiuseppe De Berardinis, Angelo Fontana, Adele Cutignano
Format: Article
Language:English
Published: MDPI AG 2019-02-01
Series:Marine Drugs
Subjects:
marine diatom
<i>Thalassiosira weissflogii</i>
phosphogalactolipids
Toll-like receptor 4
dendritic cells
immunostimulatory lipid
phosphoglycolipid synthesis
Online Access:https://www.mdpi.com/1660-3397/17/2/103

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