Constituents of <i>Huberantha jenkinsii</i> and Their Biological Activities

• Main Authors: Htoo Tint San, Tanawat Chaowasku, Wanwimon Mekboonsonglarp, Ratchanee Rodsiri, Boonchoo Sritularak, Hathairat Buraphaka, Waraporn Putalun, Kittisak Likhitwitayawuid
• Format: Article
• Language: English
• Published: MDPI AG 2020-08-01
• Series: Molecules
• Subjects: <i>Huberantha jenkinsii</i>; glucose uptake; α-glucosidase; Parkinsonism; diabetes
• Online Access: https://www.mdpi.com/1420-3049/25/15/3533

The phytochemical investigation of <i>Huberantha jenkinsii</i> resulted in the isolation of two new and five known compounds. The new compounds were characterized as undescribed 8-oxoprotoberberine alkaloids and named huberanthines A and B, whereas the known compounds were identified as allantoin, oxylopinine, <i>N</i>-<i>trans</i>-feruloyl tyramine, <i>N-trans-p-</i>coumaroyl tyramine, and mangiferin. The structure determination was accomplished by spectroscopic methods. To evaluate therapeutic potential in diabetes and Parkinson’s disease, the isolates were subjected to assays for their α-glucosidase inhibitory activity, cellular glucose uptake stimulatory activity, and protective activity against neurotoxicity induced by 6-hydroxydopamine (6-OHDA). The results suggested that mangiferin was the most promising lead compound, demonstrating significant activity in all the test systems.