Type VI Secretion Effectors: Methodologies and Biology
The type VI secretion system (T6SS) is a nanomachine deployed by many Gram-negative bacteria as a weapon against eukaryotic hosts or prokaryotic competitors. It assembles into a bacteriophage tail-like structure that can transport effector proteins into the environment or target cells for competitiv...
Main Authors: | , |
---|---|
Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2017-06-01
|
Series: | Frontiers in Cellular and Infection Microbiology |
Subjects: | |
Online Access: | http://journal.frontiersin.org/article/10.3389/fcimb.2017.00254/full |
id |
doaj-4fb23520441148b3b702ceec46a87f37 |
---|---|
record_format |
Article |
spelling |
doaj-4fb23520441148b3b702ceec46a87f372020-11-24T21:01:29ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882017-06-01710.3389/fcimb.2017.00254270079Type VI Secretion Effectors: Methodologies and BiologyYun-Wei Lien0Yun-Wei Lien1Erh-Min Lai2Erh-Min Lai3Institute of Plant and Microbial Biology, Academia SinicaTaipei, TaiwanDepartment of Plant Pathology and Microbiology, National Taiwan UniversityTaipei, TaiwanInstitute of Plant and Microbial Biology, Academia SinicaTaipei, TaiwanDepartment of Plant Pathology and Microbiology, National Taiwan UniversityTaipei, TaiwanThe type VI secretion system (T6SS) is a nanomachine deployed by many Gram-negative bacteria as a weapon against eukaryotic hosts or prokaryotic competitors. It assembles into a bacteriophage tail-like structure that can transport effector proteins into the environment or target cells for competitive survival or pathogenesis. T6SS effectors have been identified by a variety of approaches, including knowledge/hypothesis-dependent and discovery-driven approaches. Here, we review and discuss the methods that have been used to identify T6SS effectors and the biological and biochemical functions of known effectors. On the basis of the nature and transport mechanisms of T6SS effectors, we further propose potential strategies that may be applicable to identify new T6SS effectors.http://journal.frontiersin.org/article/10.3389/fcimb.2017.00254/fulltype VI secretion systemmethodologyeffectortoxin-immunityproteomicsbioinformatics |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yun-Wei Lien Yun-Wei Lien Erh-Min Lai Erh-Min Lai |
spellingShingle |
Yun-Wei Lien Yun-Wei Lien Erh-Min Lai Erh-Min Lai Type VI Secretion Effectors: Methodologies and Biology Frontiers in Cellular and Infection Microbiology type VI secretion system methodology effector toxin-immunity proteomics bioinformatics |
author_facet |
Yun-Wei Lien Yun-Wei Lien Erh-Min Lai Erh-Min Lai |
author_sort |
Yun-Wei Lien |
title |
Type VI Secretion Effectors: Methodologies and Biology |
title_short |
Type VI Secretion Effectors: Methodologies and Biology |
title_full |
Type VI Secretion Effectors: Methodologies and Biology |
title_fullStr |
Type VI Secretion Effectors: Methodologies and Biology |
title_full_unstemmed |
Type VI Secretion Effectors: Methodologies and Biology |
title_sort |
type vi secretion effectors: methodologies and biology |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Cellular and Infection Microbiology |
issn |
2235-2988 |
publishDate |
2017-06-01 |
description |
The type VI secretion system (T6SS) is a nanomachine deployed by many Gram-negative bacteria as a weapon against eukaryotic hosts or prokaryotic competitors. It assembles into a bacteriophage tail-like structure that can transport effector proteins into the environment or target cells for competitive survival or pathogenesis. T6SS effectors have been identified by a variety of approaches, including knowledge/hypothesis-dependent and discovery-driven approaches. Here, we review and discuss the methods that have been used to identify T6SS effectors and the biological and biochemical functions of known effectors. On the basis of the nature and transport mechanisms of T6SS effectors, we further propose potential strategies that may be applicable to identify new T6SS effectors. |
topic |
type VI secretion system methodology effector toxin-immunity proteomics bioinformatics |
url |
http://journal.frontiersin.org/article/10.3389/fcimb.2017.00254/full |
work_keys_str_mv |
AT yunweilien typevisecretioneffectorsmethodologiesandbiology AT yunweilien typevisecretioneffectorsmethodologiesandbiology AT erhminlai typevisecretioneffectorsmethodologiesandbiology AT erhminlai typevisecretioneffectorsmethodologiesandbiology |
_version_ |
1716777855425183744 |