A Computational Study of Astrocytic GABA Release at the Glutamatergic Synapse: EAAT-2 and GAT-3 Coupled Dynamics

A Computational Study of Astrocytic GABA Release at the Glutamatergic Synapse: EAAT-2 and GAT-3 Coupled Dynamics

Neurotransmitter dynamics within neuronal synapses can be controlled by astrocytes and reflect key contributors to neuronal activity. In particular, Glutamate (Glu) released by activated neurons is predominantly removed from the synaptic space by perisynaptic astrocytic transporters EAAT-2 (GLT-1)....

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Bibliographic Details
Main Authors: Bronac Flanagan, Liam McDaid, John Joseph Wade, Marinus Toman, KongFatt Wong-Lin, Jim Harkin
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Cellular Neuroscience
Subjects:
astrocyte
sodium-signaling
neurotransmission
synapse
glutamate
GABA
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2021.682460/full

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