From Mouse to Man and Back: Closing the Correlation Gap between Imaging and Histopathology for Lung Diseases
Lung diseases such as fibrosis, asthma, cystic fibrosis, infection and cancer are life-threatening conditions that slowly deteriorate quality of life and for which our diagnostic power is high, but our knowledge on etiology and/or effective treatment options still contains important gaps. In the con...
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doaj-4fbeb151cc7443abb9c76219433d79762020-11-25T02:58:56ZengMDPI AGDiagnostics2075-44182020-08-011063663610.3390/diagnostics10090636From Mouse to Man and Back: Closing the Correlation Gap between Imaging and Histopathology for Lung DiseasesBirger Tielemans0Kaat Dekoster1Stijn E. Verleden2Stefan Sawall3Bartosz Leszczyński4Kjell Laperre5Arno Vanstapel6Johny Verschakelen7Marc Kachelriess8Erik Verbeken9Jim Swoger10Greetje Vande Velde11Department of Imaging and Pathology, KU Leuven, University of Leuven, 3000 Leuven, BelgiumDepartment of Imaging and Pathology, KU Leuven, University of Leuven, 3000 Leuven, BelgiumDepartment of CHROMETA, BREATHE lab, KU Leuven, 3000 Leuven, BelgiumGerman Cancer Research Center (DKFZ), X-Ray Imaging and CT, Heidelberg University, 69117 Heidelberg, GermanyDepartment of Medical Physics, M. Smoluchowski Institute of Physics, Faculty of Physics, Astronomy and Applied Computer Science, Jagiellonian University, 31-007 Kraków, PolandBruker Belgium, 2550 Kontich, BelgiumDepartment of CHROMETA, BREATHE lab, KU Leuven, 3000 Leuven, BelgiumDepartment of Imaging and Pathology, KU Leuven, University of Leuven, 3000 Leuven, BelgiumGerman Cancer Research Center (DKFZ), X-Ray Imaging and CT, Heidelberg University, 69117 Heidelberg, GermanyDepartment of Imaging and Pathology, KU Leuven, University of Leuven, 3000 Leuven, BelgiumEuropean Molecular Biology Laboratory (EMBL) Barcelona, 08003 Barcelona, SpainDepartment of Imaging and Pathology, KU Leuven, University of Leuven, 3000 Leuven, BelgiumLung diseases such as fibrosis, asthma, cystic fibrosis, infection and cancer are life-threatening conditions that slowly deteriorate quality of life and for which our diagnostic power is high, but our knowledge on etiology and/or effective treatment options still contains important gaps. In the context of day-to-day practice, clinical and preclinical studies, clinicians and basic researchers team up and continuously strive to increase insights into lung disease progression, diagnostic and treatment options. To unravel disease processes and to test novel therapeutic approaches, investigators typically rely on end-stage procedures such as serum analysis, cyto-/chemokine profiles and selective tissue histology from animal models. These techniques are useful but provide only a snapshot of disease processes that are essentially dynamic in time and space. Technology allowing evaluation of live animals repeatedly is indispensable to gain a better insight into the dynamics of lung disease progression and treatment effects. Computed tomography (CT) is a clinical diagnostic imaging technique that can have enormous benefits in a research context too. Yet, the implementation of imaging techniques in laboratories lags behind. In this review we want to showcase the integrated approaches and novel developments in imaging, lung functional testing and pathological techniques that are used to assess, diagnose, quantify and treat lung disease and that may be employed in research on patients and animals. Imaging approaches result in often novel anatomical and functional biomarkers, resulting in many advantages, such as better insight in disease progression and a reduction in the numbers of animals necessary. We here showcase integrated assessment of lung disease with imaging and histopathological technologies, applied to the example of lung fibrosis. Better integration of clinical and preclinical imaging technologies with pathology will ultimately result in improved clinical translation of (therapy) study results.https://www.mdpi.com/2075-4418/10/9/636imaging-histopathology correlationμCTMRIoptical imagingvirtual biopsyclinical |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Birger Tielemans Kaat Dekoster Stijn E. Verleden Stefan Sawall Bartosz Leszczyński Kjell Laperre Arno Vanstapel Johny Verschakelen Marc Kachelriess Erik Verbeken Jim Swoger Greetje Vande Velde |
spellingShingle |
Birger Tielemans Kaat Dekoster Stijn E. Verleden Stefan Sawall Bartosz Leszczyński Kjell Laperre Arno Vanstapel Johny Verschakelen Marc Kachelriess Erik Verbeken Jim Swoger Greetje Vande Velde From Mouse to Man and Back: Closing the Correlation Gap between Imaging and Histopathology for Lung Diseases Diagnostics imaging-histopathology correlation μCT MRI optical imaging virtual biopsy clinical |
author_facet |
Birger Tielemans Kaat Dekoster Stijn E. Verleden Stefan Sawall Bartosz Leszczyński Kjell Laperre Arno Vanstapel Johny Verschakelen Marc Kachelriess Erik Verbeken Jim Swoger Greetje Vande Velde |
author_sort |
Birger Tielemans |
title |
From Mouse to Man and Back: Closing the Correlation Gap between Imaging and Histopathology for Lung Diseases |
title_short |
From Mouse to Man and Back: Closing the Correlation Gap between Imaging and Histopathology for Lung Diseases |
title_full |
From Mouse to Man and Back: Closing the Correlation Gap between Imaging and Histopathology for Lung Diseases |
title_fullStr |
From Mouse to Man and Back: Closing the Correlation Gap between Imaging and Histopathology for Lung Diseases |
title_full_unstemmed |
From Mouse to Man and Back: Closing the Correlation Gap between Imaging and Histopathology for Lung Diseases |
title_sort |
from mouse to man and back: closing the correlation gap between imaging and histopathology for lung diseases |
publisher |
MDPI AG |
series |
Diagnostics |
issn |
2075-4418 |
publishDate |
2020-08-01 |
description |
Lung diseases such as fibrosis, asthma, cystic fibrosis, infection and cancer are life-threatening conditions that slowly deteriorate quality of life and for which our diagnostic power is high, but our knowledge on etiology and/or effective treatment options still contains important gaps. In the context of day-to-day practice, clinical and preclinical studies, clinicians and basic researchers team up and continuously strive to increase insights into lung disease progression, diagnostic and treatment options. To unravel disease processes and to test novel therapeutic approaches, investigators typically rely on end-stage procedures such as serum analysis, cyto-/chemokine profiles and selective tissue histology from animal models. These techniques are useful but provide only a snapshot of disease processes that are essentially dynamic in time and space. Technology allowing evaluation of live animals repeatedly is indispensable to gain a better insight into the dynamics of lung disease progression and treatment effects. Computed tomography (CT) is a clinical diagnostic imaging technique that can have enormous benefits in a research context too. Yet, the implementation of imaging techniques in laboratories lags behind. In this review we want to showcase the integrated approaches and novel developments in imaging, lung functional testing and pathological techniques that are used to assess, diagnose, quantify and treat lung disease and that may be employed in research on patients and animals. Imaging approaches result in often novel anatomical and functional biomarkers, resulting in many advantages, such as better insight in disease progression and a reduction in the numbers of animals necessary. We here showcase integrated assessment of lung disease with imaging and histopathological technologies, applied to the example of lung fibrosis. Better integration of clinical and preclinical imaging technologies with pathology will ultimately result in improved clinical translation of (therapy) study results. |
topic |
imaging-histopathology correlation μCT MRI optical imaging virtual biopsy clinical |
url |
https://www.mdpi.com/2075-4418/10/9/636 |
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