An evidence-based evaluation on the use of platelet rich plasma in orthopedics – a review of the literature
Within orthopedics, the use of platelet-rich plasma (PRP) has been rapidly increasing in popularity, however, its true effectiveness has yet to be fully established. Several studies find that injecting PRP to the site of injury does not provide any significant benefit with respect to clinical outcom...
Main Authors: | , , |
---|---|
Format: | Article |
Language: | English |
Published: |
EDP Sciences
2017-01-01
|
Series: | SICOT-J |
Subjects: | |
Online Access: | https://doi.org/10.1051/sicotj/2017036 |
id |
doaj-4fc27b7ff35d4db4b323414608ecc84a |
---|---|
record_format |
Article |
spelling |
doaj-4fc27b7ff35d4db4b323414608ecc84a2021-04-02T10:09:17ZengEDP SciencesSICOT-J2426-88872017-01-0135710.1051/sicotj/2017036sicotj170038An evidence-based evaluation on the use of platelet rich plasma in orthopedics – a review of the literatureHussain NasirJohal HermanBhandari MohitWithin orthopedics, the use of platelet-rich plasma (PRP) has been rapidly increasing in popularity, however, its true effectiveness has yet to be fully established. Several studies find that injecting PRP to the site of injury does not provide any significant benefit with respect to clinical outcomes; however, many others report the contrary. Due to the conflicting evidence and multiple meta-analyses conducted on the topic, a literature review of high-quality evidence on the use of PRP for common orthopaedic conditions was performed. Thus far, the evidence appears to suggest that PRP may provide some benefit in patients who present with knee osteoarthritis or lateral epicondylitis. On the other hand, evidence appears to be inconsistent or shows a minimal benefit for PRP usage in rotator cuff repair, patellar and Achilles tendinopathies, hamstring injuries, anterior cruciate ligament (ACL) repair, and medial epicondylitis. There is limited confidence in the conclusions from the published meta-analyses due to issues with statistical pooling, and limited subgroup analyses exploring the substantial heterogeneity across studies. Evidence-based clinicians considering the use of PRP in their patients with musculoskeletal injuries should be weary that the literature appears to be inconsistent and thus far, inconclusive.https://doi.org/10.1051/sicotj/2017036Platelet rich plasmaOrthobiologicsEvidence-based medicineReview |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Hussain Nasir Johal Herman Bhandari Mohit |
spellingShingle |
Hussain Nasir Johal Herman Bhandari Mohit An evidence-based evaluation on the use of platelet rich plasma in orthopedics – a review of the literature SICOT-J Platelet rich plasma Orthobiologics Evidence-based medicine Review |
author_facet |
Hussain Nasir Johal Herman Bhandari Mohit |
author_sort |
Hussain Nasir |
title |
An evidence-based evaluation on the use of platelet rich plasma in orthopedics – a review of the literature |
title_short |
An evidence-based evaluation on the use of platelet rich plasma in orthopedics – a review of the literature |
title_full |
An evidence-based evaluation on the use of platelet rich plasma in orthopedics – a review of the literature |
title_fullStr |
An evidence-based evaluation on the use of platelet rich plasma in orthopedics – a review of the literature |
title_full_unstemmed |
An evidence-based evaluation on the use of platelet rich plasma in orthopedics – a review of the literature |
title_sort |
evidence-based evaluation on the use of platelet rich plasma in orthopedics – a review of the literature |
publisher |
EDP Sciences |
series |
SICOT-J |
issn |
2426-8887 |
publishDate |
2017-01-01 |
description |
Within orthopedics, the use of platelet-rich plasma (PRP) has been rapidly increasing in popularity, however, its true effectiveness has yet to be fully established. Several studies find that injecting PRP to the site of injury does not provide any significant benefit with respect to clinical outcomes; however, many others report the contrary. Due to the conflicting evidence and multiple meta-analyses conducted on the topic, a literature review of high-quality evidence on the use of PRP for common orthopaedic conditions was performed. Thus far, the evidence appears to suggest that PRP may provide some benefit in patients who present with knee osteoarthritis or lateral epicondylitis. On the other hand, evidence appears to be inconsistent or shows a minimal benefit for PRP usage in rotator cuff repair, patellar and Achilles tendinopathies, hamstring injuries, anterior cruciate ligament (ACL) repair, and medial epicondylitis. There is limited confidence in the conclusions from the published meta-analyses due to issues with statistical pooling, and limited subgroup analyses exploring the substantial heterogeneity across studies. Evidence-based clinicians considering the use of PRP in their patients with musculoskeletal injuries should be weary that the literature appears to be inconsistent and thus far, inconclusive. |
topic |
Platelet rich plasma Orthobiologics Evidence-based medicine Review |
url |
https://doi.org/10.1051/sicotj/2017036 |
work_keys_str_mv |
AT hussainnasir anevidencebasedevaluationontheuseofplateletrichplasmainorthopedicsareviewoftheliterature AT johalherman anevidencebasedevaluationontheuseofplateletrichplasmainorthopedicsareviewoftheliterature AT bhandarimohit anevidencebasedevaluationontheuseofplateletrichplasmainorthopedicsareviewoftheliterature AT hussainnasir evidencebasedevaluationontheuseofplateletrichplasmainorthopedicsareviewoftheliterature AT johalherman evidencebasedevaluationontheuseofplateletrichplasmainorthopedicsareviewoftheliterature AT bhandarimohit evidencebasedevaluationontheuseofplateletrichplasmainorthopedicsareviewoftheliterature |
_version_ |
1724167831130472448 |