Metabolic profile of women with PCOS in Brazil: a systematic review and meta-analysis
Abstract Background Polycystic ovary syndrome (PCOS) is a common endocrine disease affecting women of reproductive age and associated with reproductive and metabolic dysfunction. Few studies are available regarding metabolic traits in Brazilian women with PCOS. The aim of this systematic review and...
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doaj-4fc90398fee843e0b9bc53528f38051e2021-02-21T12:07:14ZengBMCDiabetology & Metabolic Syndrome1758-59962021-02-0113111610.1186/s13098-021-00636-5Metabolic profile of women with PCOS in Brazil: a systematic review and meta-analysisPoli Mara Spritzer0Ramon Bossardi Ramos1Lucas Bandeira Marchesan2Monica de Oliveira3Enrico Carmina4Gynecological Endocrinology Unit, Division of Endocrinology, Hospital de Clínicas de Porto AlegrePost-Graduate Program in Endocrinology, Medicine School, Universidade Federal Do Rio Grande Do SulGynecological Endocrinology Unit, Division of Endocrinology, Hospital de Clínicas de Porto AlegreInstituto de Medicina Integral Professor Fernando Figueira HospitalUniversity of Palermo School of MedicineAbstract Background Polycystic ovary syndrome (PCOS) is a common endocrine disease affecting women of reproductive age and associated with reproductive and metabolic dysfunction. Few studies are available regarding metabolic traits in Brazilian women with PCOS. The aim of this systematic review and meta-analysis was to summarize the available evidence regarding metabolic traits and comorbidities in Brazilian women with polycystic ovary syndrome (PCOS). Methods We systematically searched PubMed, Cochrane Central Register of Controlled Trials, and Embase for cross-sectional, case–control, or cohort studies focusing on populations of different regions from Brazil, published until July 31, 2019. Studies were selected if they reported PCOS diagnostic criteria. Studies without a control group were included if they presented relevant metabolic data. Results Of 4856 studies initially identified, 27 were included in the systematic review and 12 were included in the meta-analysis, for a total of 995 women with PCOS defined by Rotterdam criteria and 2275 controls from different regions of Brazil. Obesity, metabolic syndrome and IGT were prevalent, and standard mean differences for BMI (SMD 0.67, 95% CI, 0.29, 1.05), waist circumference (SMD 0.22, 95% CI 0.02, 0.41), systolic (SMD 0.66, 95% CI 0.30, 1.01) and diastolic blood pressure (SMD 0.55, 95% CI 0.24, 0.87), glucose (SMD 0.21, 95% CI 0.04, 0.38) and HOMA (SMD 0.78, 95% CI 0.52, 1.04) were significantly higher in Brazilian women with PCOS compared to controls. Lipid profile was more adverse in PCOS vs. non-PCOS women. Between-study heterogeneities were low/moderate for glucose and HOMA and moderate/high for the other variables. Conclusions The data of this systematic review and meta-analysis indicate that Brazilian women with PCOS have a worse metabolic profile than women without PCOS with no important regional differences. The prevalence of metabolic changes is intermediate in Brazil vs. other countries.https://doi.org/10.1186/s13098-021-00636-5Polycystic ovary syndromeObesityBlood pressureInsulin resistanceMetabolic abnormalitiesBrazil |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Poli Mara Spritzer Ramon Bossardi Ramos Lucas Bandeira Marchesan Monica de Oliveira Enrico Carmina |
spellingShingle |
Poli Mara Spritzer Ramon Bossardi Ramos Lucas Bandeira Marchesan Monica de Oliveira Enrico Carmina Metabolic profile of women with PCOS in Brazil: a systematic review and meta-analysis Diabetology & Metabolic Syndrome Polycystic ovary syndrome Obesity Blood pressure Insulin resistance Metabolic abnormalities Brazil |
author_facet |
Poli Mara Spritzer Ramon Bossardi Ramos Lucas Bandeira Marchesan Monica de Oliveira Enrico Carmina |
author_sort |
Poli Mara Spritzer |
title |
Metabolic profile of women with PCOS in Brazil: a systematic review and meta-analysis |
title_short |
Metabolic profile of women with PCOS in Brazil: a systematic review and meta-analysis |
title_full |
Metabolic profile of women with PCOS in Brazil: a systematic review and meta-analysis |
title_fullStr |
Metabolic profile of women with PCOS in Brazil: a systematic review and meta-analysis |
title_full_unstemmed |
Metabolic profile of women with PCOS in Brazil: a systematic review and meta-analysis |
title_sort |
metabolic profile of women with pcos in brazil: a systematic review and meta-analysis |
publisher |
BMC |
series |
Diabetology & Metabolic Syndrome |
issn |
1758-5996 |
publishDate |
2021-02-01 |
description |
Abstract Background Polycystic ovary syndrome (PCOS) is a common endocrine disease affecting women of reproductive age and associated with reproductive and metabolic dysfunction. Few studies are available regarding metabolic traits in Brazilian women with PCOS. The aim of this systematic review and meta-analysis was to summarize the available evidence regarding metabolic traits and comorbidities in Brazilian women with polycystic ovary syndrome (PCOS). Methods We systematically searched PubMed, Cochrane Central Register of Controlled Trials, and Embase for cross-sectional, case–control, or cohort studies focusing on populations of different regions from Brazil, published until July 31, 2019. Studies were selected if they reported PCOS diagnostic criteria. Studies without a control group were included if they presented relevant metabolic data. Results Of 4856 studies initially identified, 27 were included in the systematic review and 12 were included in the meta-analysis, for a total of 995 women with PCOS defined by Rotterdam criteria and 2275 controls from different regions of Brazil. Obesity, metabolic syndrome and IGT were prevalent, and standard mean differences for BMI (SMD 0.67, 95% CI, 0.29, 1.05), waist circumference (SMD 0.22, 95% CI 0.02, 0.41), systolic (SMD 0.66, 95% CI 0.30, 1.01) and diastolic blood pressure (SMD 0.55, 95% CI 0.24, 0.87), glucose (SMD 0.21, 95% CI 0.04, 0.38) and HOMA (SMD 0.78, 95% CI 0.52, 1.04) were significantly higher in Brazilian women with PCOS compared to controls. Lipid profile was more adverse in PCOS vs. non-PCOS women. Between-study heterogeneities were low/moderate for glucose and HOMA and moderate/high for the other variables. Conclusions The data of this systematic review and meta-analysis indicate that Brazilian women with PCOS have a worse metabolic profile than women without PCOS with no important regional differences. The prevalence of metabolic changes is intermediate in Brazil vs. other countries. |
topic |
Polycystic ovary syndrome Obesity Blood pressure Insulin resistance Metabolic abnormalities Brazil |
url |
https://doi.org/10.1186/s13098-021-00636-5 |
work_keys_str_mv |
AT polimaraspritzer metabolicprofileofwomenwithpcosinbrazilasystematicreviewandmetaanalysis AT ramonbossardiramos metabolicprofileofwomenwithpcosinbrazilasystematicreviewandmetaanalysis AT lucasbandeiramarchesan metabolicprofileofwomenwithpcosinbrazilasystematicreviewandmetaanalysis AT monicadeoliveira metabolicprofileofwomenwithpcosinbrazilasystematicreviewandmetaanalysis AT enricocarmina metabolicprofileofwomenwithpcosinbrazilasystematicreviewandmetaanalysis |
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