<i>ALDH2</i> p.E504K Variation and Sex Are Major Factors Associated with Current and Quitting Alcohol Drinking in Japanese Oldest Old
This study identified the factors associated with current and quitting alcohol drinking in the Oldest Old to better understand the associated factors and mechanisms underlying drinking behaviors in this age group. Results of a questionnaire for drinking behavior in 1015 Japanese Oldest Old citizens...
Main Authors: | , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2021-05-01
|
Series: | Genes |
Subjects: | |
Online Access: | https://www.mdpi.com/2073-4425/12/6/799 |
id |
doaj-4fcbc59489de4202a65cbe71836100c6 |
---|---|
record_format |
Article |
spelling |
doaj-4fcbc59489de4202a65cbe71836100c62021-06-01T00:57:11ZengMDPI AGGenes2073-44252021-05-011279979910.3390/genes12060799<i>ALDH2</i> p.E504K Variation and Sex Are Major Factors Associated with Current and Quitting Alcohol Drinking in Japanese Oldest OldTakashi Sasaki0Yoshinori Nishimoto1Takumi Hirata2Yukiko Abe3Toru Takebayashi4Yasumichi Arai5Center for Supercentenarian Medical Research, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, JapanCenter for Supercentenarian Medical Research, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, JapanCenter for Supercentenarian Medical Research, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, JapanCenter for Supercentenarian Medical Research, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, JapanDepartment of Preventive Medicine and Public Health, Keio University School of Medicine, Tokyo 160-8582, JapanCenter for Supercentenarian Medical Research, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, JapanThis study identified the factors associated with current and quitting alcohol drinking in the Oldest Old to better understand the associated factors and mechanisms underlying drinking behaviors in this age group. Results of a questionnaire for drinking behavior in 1015 Japanese Oldest Old citizens aged 85 to 89 years revealed that 56.0% of men and 24.0% of women were current drinkers. A genome-wide association study revealed that the rs671 G > A variation, which corresponds to the aldehyde dehydrogenase 2 (<i>ALDH2</i>) p.E504K missense variant, was significantly associated with current drinking (odds ratio: 3.8, <i>p</i> = 3.33 × 10<sup>−31</sup>). Variable selection with 41 factors and multivariate regression logistic analysis for current drinking indicated that the rs671 genotype and sex were the most significant factors in the Oldest Old. Further analysis revealed that the rs671 genotype, alcohol-associated biomarkers, a history of heart or kidney disease, and frailty score are factors associated with quitting drinking in the Oldest Old men, whereas smoking history, walking time, and depression score were factors associated with quitting drinking in the Oldest Old women. These results indicate that the <i>ALDH2</i> p.E504K variation is a major factor associated with current and quitting drinking in the Japanese Oldest Old.https://www.mdpi.com/2073-4425/12/6/799alcoholcurrent drinkingOldest OldALDH2rs671 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Takashi Sasaki Yoshinori Nishimoto Takumi Hirata Yukiko Abe Toru Takebayashi Yasumichi Arai |
spellingShingle |
Takashi Sasaki Yoshinori Nishimoto Takumi Hirata Yukiko Abe Toru Takebayashi Yasumichi Arai <i>ALDH2</i> p.E504K Variation and Sex Are Major Factors Associated with Current and Quitting Alcohol Drinking in Japanese Oldest Old Genes alcohol current drinking Oldest Old ALDH2 rs671 |
author_facet |
Takashi Sasaki Yoshinori Nishimoto Takumi Hirata Yukiko Abe Toru Takebayashi Yasumichi Arai |
author_sort |
Takashi Sasaki |
title |
<i>ALDH2</i> p.E504K Variation and Sex Are Major Factors Associated with Current and Quitting Alcohol Drinking in Japanese Oldest Old |
title_short |
<i>ALDH2</i> p.E504K Variation and Sex Are Major Factors Associated with Current and Quitting Alcohol Drinking in Japanese Oldest Old |
title_full |
<i>ALDH2</i> p.E504K Variation and Sex Are Major Factors Associated with Current and Quitting Alcohol Drinking in Japanese Oldest Old |
title_fullStr |
<i>ALDH2</i> p.E504K Variation and Sex Are Major Factors Associated with Current and Quitting Alcohol Drinking in Japanese Oldest Old |
title_full_unstemmed |
<i>ALDH2</i> p.E504K Variation and Sex Are Major Factors Associated with Current and Quitting Alcohol Drinking in Japanese Oldest Old |
title_sort |
<i>aldh2</i> p.e504k variation and sex are major factors associated with current and quitting alcohol drinking in japanese oldest old |
publisher |
MDPI AG |
series |
Genes |
issn |
2073-4425 |
publishDate |
2021-05-01 |
description |
This study identified the factors associated with current and quitting alcohol drinking in the Oldest Old to better understand the associated factors and mechanisms underlying drinking behaviors in this age group. Results of a questionnaire for drinking behavior in 1015 Japanese Oldest Old citizens aged 85 to 89 years revealed that 56.0% of men and 24.0% of women were current drinkers. A genome-wide association study revealed that the rs671 G > A variation, which corresponds to the aldehyde dehydrogenase 2 (<i>ALDH2</i>) p.E504K missense variant, was significantly associated with current drinking (odds ratio: 3.8, <i>p</i> = 3.33 × 10<sup>−31</sup>). Variable selection with 41 factors and multivariate regression logistic analysis for current drinking indicated that the rs671 genotype and sex were the most significant factors in the Oldest Old. Further analysis revealed that the rs671 genotype, alcohol-associated biomarkers, a history of heart or kidney disease, and frailty score are factors associated with quitting drinking in the Oldest Old men, whereas smoking history, walking time, and depression score were factors associated with quitting drinking in the Oldest Old women. These results indicate that the <i>ALDH2</i> p.E504K variation is a major factor associated with current and quitting drinking in the Japanese Oldest Old. |
topic |
alcohol current drinking Oldest Old ALDH2 rs671 |
url |
https://www.mdpi.com/2073-4425/12/6/799 |
work_keys_str_mv |
AT takashisasaki ialdh2ipe504kvariationandsexaremajorfactorsassociatedwithcurrentandquittingalcoholdrinkinginjapaneseoldestold AT yoshinorinishimoto ialdh2ipe504kvariationandsexaremajorfactorsassociatedwithcurrentandquittingalcoholdrinkinginjapaneseoldestold AT takumihirata ialdh2ipe504kvariationandsexaremajorfactorsassociatedwithcurrentandquittingalcoholdrinkinginjapaneseoldestold AT yukikoabe ialdh2ipe504kvariationandsexaremajorfactorsassociatedwithcurrentandquittingalcoholdrinkinginjapaneseoldestold AT torutakebayashi ialdh2ipe504kvariationandsexaremajorfactorsassociatedwithcurrentandquittingalcoholdrinkinginjapaneseoldestold AT yasumichiarai ialdh2ipe504kvariationandsexaremajorfactorsassociatedwithcurrentandquittingalcoholdrinkinginjapaneseoldestold |
_version_ |
1721413399957471232 |