Sleep Duration and Risk of Lung Cancer in the Physicians' Health Study

• Main Authors: Owais KHAWAJA, Andrew B. PETRONE, Sohaib ALEEM, Kamran MANZOOR, John M GAZIANO, Luc DJOUSSE
• Format: Article
• Language: zho
• Published: Chinese Anti-Cancer Association; Chinese Antituberculosis Association 2014-09-01
• Series: Chinese Journal of Lung Cancer
• Subjects: Sleep; Lung neoplasms; Risk factors; Epidemiology
• Online Access: http://dx.doi.org/10.3779/j.issn.1009-3419.2014.09.02

Background and Objectives: Lung cancer is the most common cancer and cancer related cause of death worldwide. However, the association between sleep duration and incident lung cancer has not been investigated in a prospective cohort study. 
Methods: We prospectively examined the association between sleep duration and incident lung cancer in a cohort of 21,026 United States (US) male physicians. Self-reported sleep duration was ascertained during 2002 annual follow-up questionnaire. Incident lung cancer was ascertained through yearly follow-up questionnaires. Cox regression was used to estimate relative risk of incident lung cancer. 
Results: The average age at baseline was 68.3±8.8 yr. During a mean follow up of 7.5 (±2.2) yr, 150 cases of lung cancer occurred. Using 7 h of sleep as the reference group, multivariable adjusted hazard ratios (95%CI) for lung cancer were 1.18 (0.77-1.82), 1.0 (ref), and 0.97 (0.67-1.41) from lowest to the highest category of sleep duration (P for quadratic trend 0.697), respectively. In a secondary analysis, smoking status did not modify the sleep duration-lung cancer association (P=0.78). There was no evidence for an interaction between sleep duration and sleep apnea on the risk of lung cancer either (P=0.65). 
Conclusions: Our data failed to show a higher risk of lung cancer in association with altered sleep duration among US male physicians.