Genetic Association between Methylenetetrahydrofolate Reductase Gene Polymorphism and Risk of Osteonecrosis of the Femoral Head
Background. Methylenetetrahydrofolate reductase (MTHFR) SNP rs1801133 has been frequently investigated in recent years. Relevant candidate gene association studies with this SNP and osteonecrosis of the femoral head (ONFH) reported conflicting results. Meta-analysis provides a method to combine thes...
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doaj-4fd22367b5524fef8c9bef39547b75e62020-11-24T21:06:11ZengHindawi LimitedBioMed Research International2314-61332314-61412015-01-01201510.1155/2015/196495196495Genetic Association between Methylenetetrahydrofolate Reductase Gene Polymorphism and Risk of Osteonecrosis of the Femoral HeadWei Chai0Zhendong Zhang1Ming Ni2Peiliang Geng3Zijian Lian4Guoqiang Zhang5Lewis L. Shi6Jiying Chen7Department of Orthopaedics, Chinese People’s Liberation Army General Hospital, 301 Orthopaedic Hospital, 28 Fuxing Road, Haidian District, Beijing 100853, ChinaDepartment of Orthopaedics, Chinese People’s Liberation Army General Hospital, 301 Orthopaedic Hospital, 28 Fuxing Road, Haidian District, Beijing 100853, ChinaDepartment of Orthopaedics, Chinese People’s Liberation Army General Hospital, 301 Orthopaedic Hospital, 28 Fuxing Road, Haidian District, Beijing 100853, ChinaCancer Center, Division of Internal Medicine, Chinese PLA General Hospital & Chinese PLA Medical School, 28 Fuxing Road, Haidian District, Beijing 100853, ChinaMedical School of Nankai University, 94 Weijin Road, Tianjin 300071, ChinaDepartment of Orthopaedics, Chinese People’s Liberation Army General Hospital, 301 Orthopaedic Hospital, 28 Fuxing Road, Haidian District, Beijing 100853, ChinaDepartment of Orthopaedics, University of Chicago Hospital, 5841 S. Maryland Avenue, Chicago, IL 60637, USADepartment of Orthopaedics, Chinese People’s Liberation Army General Hospital, 301 Orthopaedic Hospital, 28 Fuxing Road, Haidian District, Beijing 100853, ChinaBackground. Methylenetetrahydrofolate reductase (MTHFR) SNP rs1801133 has been frequently investigated in recent years. Relevant candidate gene association studies with this SNP and osteonecrosis of the femoral head (ONFH) reported conflicting results. Meta-analysis provides a method to combine these data and to determine the association in a larger sample size. Method. We conducted a systematic search to identify possible studies. Four pooled ORs (odds ratios, T versus C, TT versus CC, TT/CT versus CC, and TT versus CT/CC), along with 95% confidence interval (CI), were calculated to evaluate the association between SNP rs1801133 and ONFH susceptibility. Both fixed effects model and random effects model were used. Findings. We eventually included twelve studies in this analysis, with results showing no overall association between ONFH susceptibility and SNP rs1801133 (T versus C: OR=1.15, 95% CI=0.97–1.38; TT versus CC: OR=1.15, 95% CI=0.91–1.46; TT/CT versus CC: OR=1.09, 95% CI=0.95–1.25; and TT versus CT/CC: OR=1.16, 95% CI=0.93–1.45). When stratified based on ethnicity, the results were still not significant. Conclusion. Our findings are generally supportive of no association between MTHFR SNP rs1801133 and the etiology of ONFH.http://dx.doi.org/10.1155/2015/196495 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Wei Chai Zhendong Zhang Ming Ni Peiliang Geng Zijian Lian Guoqiang Zhang Lewis L. Shi Jiying Chen |
spellingShingle |
Wei Chai Zhendong Zhang Ming Ni Peiliang Geng Zijian Lian Guoqiang Zhang Lewis L. Shi Jiying Chen Genetic Association between Methylenetetrahydrofolate Reductase Gene Polymorphism and Risk of Osteonecrosis of the Femoral Head BioMed Research International |
author_facet |
Wei Chai Zhendong Zhang Ming Ni Peiliang Geng Zijian Lian Guoqiang Zhang Lewis L. Shi Jiying Chen |
author_sort |
Wei Chai |
title |
Genetic Association between Methylenetetrahydrofolate Reductase Gene Polymorphism and Risk of Osteonecrosis of the Femoral Head |
title_short |
Genetic Association between Methylenetetrahydrofolate Reductase Gene Polymorphism and Risk of Osteonecrosis of the Femoral Head |
title_full |
Genetic Association between Methylenetetrahydrofolate Reductase Gene Polymorphism and Risk of Osteonecrosis of the Femoral Head |
title_fullStr |
Genetic Association between Methylenetetrahydrofolate Reductase Gene Polymorphism and Risk of Osteonecrosis of the Femoral Head |
title_full_unstemmed |
Genetic Association between Methylenetetrahydrofolate Reductase Gene Polymorphism and Risk of Osteonecrosis of the Femoral Head |
title_sort |
genetic association between methylenetetrahydrofolate reductase gene polymorphism and risk of osteonecrosis of the femoral head |
publisher |
Hindawi Limited |
series |
BioMed Research International |
issn |
2314-6133 2314-6141 |
publishDate |
2015-01-01 |
description |
Background. Methylenetetrahydrofolate reductase (MTHFR) SNP rs1801133 has been frequently investigated in recent years. Relevant candidate gene association studies with this SNP and osteonecrosis of the femoral head (ONFH) reported conflicting results. Meta-analysis provides a method to combine these data and to determine the association in a larger sample size. Method. We conducted a systematic search to identify possible studies. Four pooled ORs (odds ratios, T versus C, TT versus CC, TT/CT versus CC, and TT versus CT/CC), along with 95% confidence interval (CI), were calculated to evaluate the association between SNP rs1801133 and ONFH susceptibility. Both fixed effects model and random effects model were used. Findings. We eventually included twelve studies in this analysis, with results showing no overall association between ONFH susceptibility and SNP rs1801133 (T versus C: OR=1.15, 95% CI=0.97–1.38; TT versus CC: OR=1.15, 95% CI=0.91–1.46; TT/CT versus CC: OR=1.09, 95% CI=0.95–1.25; and TT versus CT/CC: OR=1.16, 95% CI=0.93–1.45). When stratified based on ethnicity, the results were still not significant. Conclusion. Our findings are generally supportive of no association between MTHFR SNP rs1801133 and the etiology of ONFH. |
url |
http://dx.doi.org/10.1155/2015/196495 |
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