Group 2 Innate Lymphoid Cells in Pulmonary Immunity and Tissue Homeostasis
Group 2 innate lymphoid cells (ILC2) represent an evolutionary rather old but only recently identified member of the family of innate lymphoid cells and have received much attention since their detailed description in 2010. They can orchestrate innate as well as adaptive immune responses as they int...
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doaj-4fd5cf2f2f64463899d1f827936a6e9f2020-11-25T00:32:54ZengFrontiers Media S.A.Frontiers in Immunology1664-32242018-04-01910.3389/fimmu.2018.00840342604Group 2 Innate Lymphoid Cells in Pulmonary Immunity and Tissue HomeostasisBarbara C. Mindt0Barbara C. Mindt1Barbara C. Mindt2Jörg H. Fritz3Jörg H. Fritz4Jörg H. Fritz5Jörg H. Fritz6Claudia U. Duerr7Claudia U. Duerr8Claudia U. Duerr9Claudia U. Duerr10Department of Microbiology and Immunology, McGill University, Montreal, QC, CanadaMcGill University Research Centre on Complex Traits (MRCCT), McGill University, Montreal, QC, CanadaFOCiS Centre of Excellence in Translational Immunology (CETI), McGill University, Montreal, QC, CanadaDepartment of Microbiology and Immunology, McGill University, Montreal, QC, CanadaMcGill University Research Centre on Complex Traits (MRCCT), McGill University, Montreal, QC, CanadaFOCiS Centre of Excellence in Translational Immunology (CETI), McGill University, Montreal, QC, CanadaDepartment of Physiology, McGill University, Montreal, QC, CanadaDepartment of Microbiology and Immunology, McGill University, Montreal, QC, CanadaMcGill University Research Centre on Complex Traits (MRCCT), McGill University, Montreal, QC, CanadaFOCiS Centre of Excellence in Translational Immunology (CETI), McGill University, Montreal, QC, CanadaInstitute of Microbiology and Infection Immunology, Charité – University Medical Centre Berlin, Berlin, GermanyGroup 2 innate lymphoid cells (ILC2) represent an evolutionary rather old but only recently identified member of the family of innate lymphoid cells and have received much attention since their detailed description in 2010. They can orchestrate innate as well as adaptive immune responses as they interact with and influence several immune and non-immune cell populations. Moreover, ILC2 are able to rapidly secrete large amounts of type 2 cytokines that can contribute to protective but also detrimental host immune responses depending on timing, location, and physiological context. Interestingly, ILC2, despite their scarcity, are the dominant innate lymphoid cell population in the lung, indicating a key role as first responders and amplifiers upon immune challenge at this site. In addition, the recently described tissue residency of ILC2 further underlines the importance of their respective microenvironment. In this review, we provide an overview of lung physiology including a description of the most prominent pulmonary resident cells together with a review of known and potential ILC2 interactions within this unique environment. We will further outline recent observations regarding pulmonary ILC2 during immune challenge including respiratory infections and discuss different models and approaches to study ILC2 biology in the lung.http://journal.frontiersin.org/article/10.3389/fimmu.2018.00840/fullgroup 2 innate lymphoid cellsrespiratory tractinnate immune responseslung physiologypulmonary microenvironment |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Barbara C. Mindt Barbara C. Mindt Barbara C. Mindt Jörg H. Fritz Jörg H. Fritz Jörg H. Fritz Jörg H. Fritz Claudia U. Duerr Claudia U. Duerr Claudia U. Duerr Claudia U. Duerr |
spellingShingle |
Barbara C. Mindt Barbara C. Mindt Barbara C. Mindt Jörg H. Fritz Jörg H. Fritz Jörg H. Fritz Jörg H. Fritz Claudia U. Duerr Claudia U. Duerr Claudia U. Duerr Claudia U. Duerr Group 2 Innate Lymphoid Cells in Pulmonary Immunity and Tissue Homeostasis Frontiers in Immunology group 2 innate lymphoid cells respiratory tract innate immune responses lung physiology pulmonary microenvironment |
author_facet |
Barbara C. Mindt Barbara C. Mindt Barbara C. Mindt Jörg H. Fritz Jörg H. Fritz Jörg H. Fritz Jörg H. Fritz Claudia U. Duerr Claudia U. Duerr Claudia U. Duerr Claudia U. Duerr |
author_sort |
Barbara C. Mindt |
title |
Group 2 Innate Lymphoid Cells in Pulmonary Immunity and Tissue Homeostasis |
title_short |
Group 2 Innate Lymphoid Cells in Pulmonary Immunity and Tissue Homeostasis |
title_full |
Group 2 Innate Lymphoid Cells in Pulmonary Immunity and Tissue Homeostasis |
title_fullStr |
Group 2 Innate Lymphoid Cells in Pulmonary Immunity and Tissue Homeostasis |
title_full_unstemmed |
Group 2 Innate Lymphoid Cells in Pulmonary Immunity and Tissue Homeostasis |
title_sort |
group 2 innate lymphoid cells in pulmonary immunity and tissue homeostasis |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Immunology |
issn |
1664-3224 |
publishDate |
2018-04-01 |
description |
Group 2 innate lymphoid cells (ILC2) represent an evolutionary rather old but only recently identified member of the family of innate lymphoid cells and have received much attention since their detailed description in 2010. They can orchestrate innate as well as adaptive immune responses as they interact with and influence several immune and non-immune cell populations. Moreover, ILC2 are able to rapidly secrete large amounts of type 2 cytokines that can contribute to protective but also detrimental host immune responses depending on timing, location, and physiological context. Interestingly, ILC2, despite their scarcity, are the dominant innate lymphoid cell population in the lung, indicating a key role as first responders and amplifiers upon immune challenge at this site. In addition, the recently described tissue residency of ILC2 further underlines the importance of their respective microenvironment. In this review, we provide an overview of lung physiology including a description of the most prominent pulmonary resident cells together with a review of known and potential ILC2 interactions within this unique environment. We will further outline recent observations regarding pulmonary ILC2 during immune challenge including respiratory infections and discuss different models and approaches to study ILC2 biology in the lung. |
topic |
group 2 innate lymphoid cells respiratory tract innate immune responses lung physiology pulmonary microenvironment |
url |
http://journal.frontiersin.org/article/10.3389/fimmu.2018.00840/full |
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