Dysregulation of TCTP in Biological Processes and Diseases
Translationally controlled tumor protein (TCTP), also called histamine releasing factor (HRF) or fortilin, is a multifunctional protein present in almost all eukaryotic organisms. TCTP is involved in a range of basic cell biological processes, such as promotion of growth and development, or cellular...
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doaj-4fd75a38338b4e3db5105378a55ea06c2020-11-25T03:48:36ZengMDPI AGCells2073-44092020-07-0191632163210.3390/cells9071632Dysregulation of TCTP in Biological Processes and DiseasesUlrich-Axel Bommer0Adam Telerman1School of Medicine, Faculty of Science, Medicine & Health, University of Wollongong, Wollongong, NSW 2522, AustraliaInstitut Gustave Roussy, Unite Inserm U981, 94805 Villejuif, FranceTranslationally controlled tumor protein (TCTP), also called histamine releasing factor (HRF) or fortilin, is a multifunctional protein present in almost all eukaryotic organisms. TCTP is involved in a range of basic cell biological processes, such as promotion of growth and development, or cellular defense in response to biological stresses. Cellular TCTP levels are highly regulated in response to a variety of physiological signals, and regulatory mechanism at various levels have been elucidated. Given the importance of TCTP in maintaining cellular homeostasis, it is not surprising that dysregulation of this protein is associated with a range of disease processes. Here, we review recent progress that has been made in the characterisation of the basic biological functions of TCTP, in the description of mechanisms involved in regulating its cellular levels and in the understanding of dysregulation of TCTP, as it occurs in disease processes such as cancer.https://www.mdpi.com/2073-4409/9/7/1632TCTP (HRF, fortilin)growth and developmentbiological stress reactionsautophagyregulation of protein synthesisregulated protein degradation |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ulrich-Axel Bommer Adam Telerman |
spellingShingle |
Ulrich-Axel Bommer Adam Telerman Dysregulation of TCTP in Biological Processes and Diseases Cells TCTP (HRF, fortilin) growth and development biological stress reactions autophagy regulation of protein synthesis regulated protein degradation |
author_facet |
Ulrich-Axel Bommer Adam Telerman |
author_sort |
Ulrich-Axel Bommer |
title |
Dysregulation of TCTP in Biological Processes and Diseases |
title_short |
Dysregulation of TCTP in Biological Processes and Diseases |
title_full |
Dysregulation of TCTP in Biological Processes and Diseases |
title_fullStr |
Dysregulation of TCTP in Biological Processes and Diseases |
title_full_unstemmed |
Dysregulation of TCTP in Biological Processes and Diseases |
title_sort |
dysregulation of tctp in biological processes and diseases |
publisher |
MDPI AG |
series |
Cells |
issn |
2073-4409 |
publishDate |
2020-07-01 |
description |
Translationally controlled tumor protein (TCTP), also called histamine releasing factor (HRF) or fortilin, is a multifunctional protein present in almost all eukaryotic organisms. TCTP is involved in a range of basic cell biological processes, such as promotion of growth and development, or cellular defense in response to biological stresses. Cellular TCTP levels are highly regulated in response to a variety of physiological signals, and regulatory mechanism at various levels have been elucidated. Given the importance of TCTP in maintaining cellular homeostasis, it is not surprising that dysregulation of this protein is associated with a range of disease processes. Here, we review recent progress that has been made in the characterisation of the basic biological functions of TCTP, in the description of mechanisms involved in regulating its cellular levels and in the understanding of dysregulation of TCTP, as it occurs in disease processes such as cancer. |
topic |
TCTP (HRF, fortilin) growth and development biological stress reactions autophagy regulation of protein synthesis regulated protein degradation |
url |
https://www.mdpi.com/2073-4409/9/7/1632 |
work_keys_str_mv |
AT ulrichaxelbommer dysregulationoftctpinbiologicalprocessesanddiseases AT adamtelerman dysregulationoftctpinbiologicalprocessesanddiseases |
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1724498116434984960 |