Epidemiology, risk factors and clinical course of SARS-CoV-2 infected patients in a Swiss university hospital: An observational retrospective study.
<h4>Background</h4>This study aims to describe the epidemiology of COVID-19 patients in a Swiss university hospital.<h4>Methods</h4>This retrospective observational study included all adult patients hospitalized with a laboratory confirmed SARS-CoV-2 infection from March 1 to...
Main Authors: | , , , , , , , , , , , , , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2020-01-01
|
Series: | PLoS ONE |
Online Access: | https://doi.org/10.1371/journal.pone.0240781 |
id |
doaj-4fd7aecb0ece4010acfdb3a1fcb173bb |
---|---|
record_format |
Article |
spelling |
doaj-4fd7aecb0ece4010acfdb3a1fcb173bb2021-03-04T11:52:29ZengPublic Library of Science (PLoS)PLoS ONE1932-62032020-01-011511e024078110.1371/journal.pone.0240781Epidemiology, risk factors and clinical course of SARS-CoV-2 infected patients in a Swiss university hospital: An observational retrospective study.Jean ReginaMatthaios Papadimitriou-OlivgerisRaphaël BurgerMarie-Annick Le PogamTapio NiemiParaskevas FilippidisJonathan TschoppFlorian DesgrangesBenjamin VialaEleftheria KampouriLaurence RochatDavid HaefligerMehdi BelkonieneCarlos FidalgoAntonios KritikosKatia JatonLaurence SennPierre-Alexandre BartJean-Luc PaganiOriol ManuelLoïc Lhopitallier<h4>Background</h4>This study aims to describe the epidemiology of COVID-19 patients in a Swiss university hospital.<h4>Methods</h4>This retrospective observational study included all adult patients hospitalized with a laboratory confirmed SARS-CoV-2 infection from March 1 to March 25, 2020. We extracted data from electronic health records. The primary outcome was the need to mechanical ventilation at day 14. We used multivariate logistic regression to identify risk factors for mechanical ventilation. Follow-up was of at least 14 days.<h4>Results</h4>145 patients were included in the multivariate model, of whom 36 (24.8%) needed mechanical ventilation at 14 days. The median time from symptoms onset to mechanical ventilation was 9·5 days (IQR 7.00, 12.75). Multivariable regression showed increased odds of mechanical ventilation with age (OR 1.09 per year, 95% CI 1.03-1.16, p = 0.002), in males (OR 6.99, 95% CI 1.68-29.03, p = 0.007), in patients who presented with a qSOFA score ≥2 (OR 7.24, 95% CI 1.64-32.03, p = 0.009), with bilateral infiltrate (OR 18.92, 3.94-98.23, p<0.001) or with a CRP of 40 mg/l or greater (OR 5.44, 1.18-25.25; p = 0.030) on admission. Patients with more than seven days of symptoms on admission had decreased odds of mechanical ventilation (0.087, 95% CI 0.02-0.38, p = 0.001).<h4>Conclusions</h4>This study gives some insight in the epidemiology and clinical course of patients admitted in a European tertiary hospital with SARS-CoV-2 infection. Age, male sex, high qSOFA score, CRP of 40 mg/l or greater and a bilateral radiological infiltrate could help clinicians identify patients at high risk for mechanical ventilation.https://doi.org/10.1371/journal.pone.0240781 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jean Regina Matthaios Papadimitriou-Olivgeris Raphaël Burger Marie-Annick Le Pogam Tapio Niemi Paraskevas Filippidis Jonathan Tschopp Florian Desgranges Benjamin Viala Eleftheria Kampouri Laurence Rochat David Haefliger Mehdi Belkoniene Carlos Fidalgo Antonios Kritikos Katia Jaton Laurence Senn Pierre-Alexandre Bart Jean-Luc Pagani Oriol Manuel Loïc Lhopitallier |
spellingShingle |
Jean Regina Matthaios Papadimitriou-Olivgeris Raphaël Burger Marie-Annick Le Pogam Tapio Niemi Paraskevas Filippidis Jonathan Tschopp Florian Desgranges Benjamin Viala Eleftheria Kampouri Laurence Rochat David Haefliger Mehdi Belkoniene Carlos Fidalgo Antonios Kritikos Katia Jaton Laurence Senn Pierre-Alexandre Bart Jean-Luc Pagani Oriol Manuel Loïc Lhopitallier Epidemiology, risk factors and clinical course of SARS-CoV-2 infected patients in a Swiss university hospital: An observational retrospective study. PLoS ONE |
author_facet |
Jean Regina Matthaios Papadimitriou-Olivgeris Raphaël Burger Marie-Annick Le Pogam Tapio Niemi Paraskevas Filippidis Jonathan Tschopp Florian Desgranges Benjamin Viala Eleftheria Kampouri Laurence Rochat David Haefliger Mehdi Belkoniene Carlos Fidalgo Antonios Kritikos Katia Jaton Laurence Senn Pierre-Alexandre Bart Jean-Luc Pagani Oriol Manuel Loïc Lhopitallier |
author_sort |
Jean Regina |
title |
Epidemiology, risk factors and clinical course of SARS-CoV-2 infected patients in a Swiss university hospital: An observational retrospective study. |
title_short |
Epidemiology, risk factors and clinical course of SARS-CoV-2 infected patients in a Swiss university hospital: An observational retrospective study. |
title_full |
Epidemiology, risk factors and clinical course of SARS-CoV-2 infected patients in a Swiss university hospital: An observational retrospective study. |
title_fullStr |
Epidemiology, risk factors and clinical course of SARS-CoV-2 infected patients in a Swiss university hospital: An observational retrospective study. |
title_full_unstemmed |
Epidemiology, risk factors and clinical course of SARS-CoV-2 infected patients in a Swiss university hospital: An observational retrospective study. |
title_sort |
epidemiology, risk factors and clinical course of sars-cov-2 infected patients in a swiss university hospital: an observational retrospective study. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2020-01-01 |
description |
<h4>Background</h4>This study aims to describe the epidemiology of COVID-19 patients in a Swiss university hospital.<h4>Methods</h4>This retrospective observational study included all adult patients hospitalized with a laboratory confirmed SARS-CoV-2 infection from March 1 to March 25, 2020. We extracted data from electronic health records. The primary outcome was the need to mechanical ventilation at day 14. We used multivariate logistic regression to identify risk factors for mechanical ventilation. Follow-up was of at least 14 days.<h4>Results</h4>145 patients were included in the multivariate model, of whom 36 (24.8%) needed mechanical ventilation at 14 days. The median time from symptoms onset to mechanical ventilation was 9·5 days (IQR 7.00, 12.75). Multivariable regression showed increased odds of mechanical ventilation with age (OR 1.09 per year, 95% CI 1.03-1.16, p = 0.002), in males (OR 6.99, 95% CI 1.68-29.03, p = 0.007), in patients who presented with a qSOFA score ≥2 (OR 7.24, 95% CI 1.64-32.03, p = 0.009), with bilateral infiltrate (OR 18.92, 3.94-98.23, p<0.001) or with a CRP of 40 mg/l or greater (OR 5.44, 1.18-25.25; p = 0.030) on admission. Patients with more than seven days of symptoms on admission had decreased odds of mechanical ventilation (0.087, 95% CI 0.02-0.38, p = 0.001).<h4>Conclusions</h4>This study gives some insight in the epidemiology and clinical course of patients admitted in a European tertiary hospital with SARS-CoV-2 infection. Age, male sex, high qSOFA score, CRP of 40 mg/l or greater and a bilateral radiological infiltrate could help clinicians identify patients at high risk for mechanical ventilation. |
url |
https://doi.org/10.1371/journal.pone.0240781 |
work_keys_str_mv |
AT jeanregina epidemiologyriskfactorsandclinicalcourseofsarscov2infectedpatientsinaswissuniversityhospitalanobservationalretrospectivestudy AT matthaiospapadimitriouolivgeris epidemiologyriskfactorsandclinicalcourseofsarscov2infectedpatientsinaswissuniversityhospitalanobservationalretrospectivestudy AT raphaelburger epidemiologyriskfactorsandclinicalcourseofsarscov2infectedpatientsinaswissuniversityhospitalanobservationalretrospectivestudy AT marieannicklepogam epidemiologyriskfactorsandclinicalcourseofsarscov2infectedpatientsinaswissuniversityhospitalanobservationalretrospectivestudy AT tapioniemi epidemiologyriskfactorsandclinicalcourseofsarscov2infectedpatientsinaswissuniversityhospitalanobservationalretrospectivestudy AT paraskevasfilippidis epidemiologyriskfactorsandclinicalcourseofsarscov2infectedpatientsinaswissuniversityhospitalanobservationalretrospectivestudy AT jonathantschopp epidemiologyriskfactorsandclinicalcourseofsarscov2infectedpatientsinaswissuniversityhospitalanobservationalretrospectivestudy AT floriandesgranges epidemiologyriskfactorsandclinicalcourseofsarscov2infectedpatientsinaswissuniversityhospitalanobservationalretrospectivestudy AT benjaminviala epidemiologyriskfactorsandclinicalcourseofsarscov2infectedpatientsinaswissuniversityhospitalanobservationalretrospectivestudy AT eleftheriakampouri epidemiologyriskfactorsandclinicalcourseofsarscov2infectedpatientsinaswissuniversityhospitalanobservationalretrospectivestudy AT laurencerochat epidemiologyriskfactorsandclinicalcourseofsarscov2infectedpatientsinaswissuniversityhospitalanobservationalretrospectivestudy AT davidhaefliger epidemiologyriskfactorsandclinicalcourseofsarscov2infectedpatientsinaswissuniversityhospitalanobservationalretrospectivestudy AT mehdibelkoniene epidemiologyriskfactorsandclinicalcourseofsarscov2infectedpatientsinaswissuniversityhospitalanobservationalretrospectivestudy AT carlosfidalgo epidemiologyriskfactorsandclinicalcourseofsarscov2infectedpatientsinaswissuniversityhospitalanobservationalretrospectivestudy AT antonioskritikos epidemiologyriskfactorsandclinicalcourseofsarscov2infectedpatientsinaswissuniversityhospitalanobservationalretrospectivestudy AT katiajaton epidemiologyriskfactorsandclinicalcourseofsarscov2infectedpatientsinaswissuniversityhospitalanobservationalretrospectivestudy AT laurencesenn epidemiologyriskfactorsandclinicalcourseofsarscov2infectedpatientsinaswissuniversityhospitalanobservationalretrospectivestudy AT pierrealexandrebart epidemiologyriskfactorsandclinicalcourseofsarscov2infectedpatientsinaswissuniversityhospitalanobservationalretrospectivestudy AT jeanlucpagani epidemiologyriskfactorsandclinicalcourseofsarscov2infectedpatientsinaswissuniversityhospitalanobservationalretrospectivestudy AT oriolmanuel epidemiologyriskfactorsandclinicalcourseofsarscov2infectedpatientsinaswissuniversityhospitalanobservationalretrospectivestudy AT loiclhopitallier epidemiologyriskfactorsandclinicalcourseofsarscov2infectedpatientsinaswissuniversityhospitalanobservationalretrospectivestudy |
_version_ |
1714803436135907328 |