Large‐Scale Asymmetric Synthesis of Fmoc‐(S)‐2‐Amino‐6,6,6‐Trifluorohexanoic Acid

Large‐Scale Asymmetric Synthesis of Fmoc‐(S)‐2‐Amino‐6,6,6‐Trifluorohexanoic Acid

Abstract Here we report the first large‐scale synthesis of Fmoc‐(S)‐2‐amino‐6,6,6‐trifluorohexanoic acid via asymmetric alkylation of chiral Ni(II)‐complex of glycine Schiff base with CF3(CH2)3I. The synthesis was performed on over 100 g scale and can be recommended as the most advanced procedure fo...

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Bibliographic Details
Main Authors: Zizhen Yin, Dr. Hiroki Moriwaki, Dr. Hidenori Abe, Dr. Toshio Miwa, Dr. Jianlin Han, Prof. Dr. Vadim A. Soloshonok
Format: Article
Language:English
Published: Wiley-VCH 2019-06-01
Series:ChemistryOpen
Subjects:
asymmetric synthesis
amino acids
fluorine
large-scale synthesis
stereochemical outcome
Online Access:https://doi.org/10.1002/open.201900131

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