Differential chromosome conformations as hallmarks of cellular identity revealed by mathematical polymer modeling.
Inherently dynamic, chromosomes adopt many different conformations in response to DNA metabolism. Models of chromosome organization in the yeast nucleus obtained from genome-wide chromosome conformation data or biophysical simulations provide important insights into the average behavior but fail to...
Main Authors: | Imen Lassadi, Alain Kamgoué, Isabelle Goiffon, Nicolas Tanguy-le-Gac, Kerstin Bystricky |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2015-06-01
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Series: | PLoS Computational Biology |
Online Access: | https://doi.org/10.1371/journal.pcbi.1004306 |
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