The Role of MicroRNAs in Regulatory T Cells

The Role of MicroRNAs in Regulatory T Cells

MicroRNAs are a class of conserved, 20 nt-23 nt long, noncoding small RNAs that inhibit expression of their respective target genes in different cell types. Regulatory T cells (Tregs) are a subpopulation of T cells that negatively regulate immune responses, which is essential to immune homeostasis....

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Main Authors: Chao Liu, Nannan Li, Guijian Liu
Format: Article
Language:English
Published: Hindawi Limited 2020-01-01
Series:Journal of Immunology Research
Online Access:http://dx.doi.org/10.1155/2020/3232061
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spelling doaj-4ff6d6a7d65e4591b80bc37ef4f0a3072020-11-25T02:10:46ZengHindawi LimitedJournal of Immunology Research2314-88612314-71562020-01-01202010.1155/2020/32320613232061The Role of MicroRNAs in Regulatory T CellsChao Liu0Nannan Li1Guijian Liu2Clinical Laboratory, Guang’anmen Hospital, China Academy of Chinese Medical Sciences, ChinaFeiyan Biotechnology Company Limited, Beijing, ChinaClinical Laboratory, Guang’anmen Hospital, China Academy of Chinese Medical Sciences, ChinaMicroRNAs are a class of conserved, 20 nt-23 nt long, noncoding small RNAs that inhibit expression of their respective target genes in different cell types. Regulatory T cells (Tregs) are a subpopulation of T cells that negatively regulate immune responses, which is essential to immune homeostasis. Recent studies have indicated that microRNAs play an important role in the proliferation, differentiation, and functions of Treg. Here, we review the recent progress in understanding the roles of microRNAs in Treg and their dysregulation in immune-related diseases. This ongoing research continues to expand the understanding of Treg regulation and the mechanisms of immune disorders.http://dx.doi.org/10.1155/2020/3232061
collection DOAJ
language English
format Article
sources DOAJ
author Chao Liu
Nannan Li
Guijian Liu
spellingShingle Chao Liu
Nannan Li
Guijian Liu
The Role of MicroRNAs in Regulatory T Cells
Journal of Immunology Research
author_facet Chao Liu
Nannan Li
Guijian Liu
author_sort Chao Liu
title The Role of MicroRNAs in Regulatory T Cells
title_short The Role of MicroRNAs in Regulatory T Cells
title_full The Role of MicroRNAs in Regulatory T Cells
title_fullStr The Role of MicroRNAs in Regulatory T Cells
title_full_unstemmed The Role of MicroRNAs in Regulatory T Cells
title_sort role of micrornas in regulatory t cells
publisher Hindawi Limited
series Journal of Immunology Research
issn 2314-8861
2314-7156
publishDate 2020-01-01
description MicroRNAs are a class of conserved, 20 nt-23 nt long, noncoding small RNAs that inhibit expression of their respective target genes in different cell types. Regulatory T cells (Tregs) are a subpopulation of T cells that negatively regulate immune responses, which is essential to immune homeostasis. Recent studies have indicated that microRNAs play an important role in the proliferation, differentiation, and functions of Treg. Here, we review the recent progress in understanding the roles of microRNAs in Treg and their dysregulation in immune-related diseases. This ongoing research continues to expand the understanding of Treg regulation and the mechanisms of immune disorders.
url http://dx.doi.org/10.1155/2020/3232061
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