Prognostic value of hyperglycemia on-admission in diabetic versus non-diabetic patients presenting with ST-elevation myocardial infarction in Tunisia
Background: Hyperglycemia on-admission is a powerful predictor of adverse events in patients presenting for ST-elevation myocardial infarction (STEMI). Aim: In this study, we sought to determine the prognostic value of hyperglycemia on-admission in Tunisian patients presenting with STEMI according t...
Main Authors: | , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
2018-11-01
|
Series: | Indian Heart Journal |
Online Access: | http://www.sciencedirect.com/science/article/pii/S0019483217304224 |
id |
doaj-500904f4b2d246bab4eadaa73b047dc1 |
---|---|
record_format |
Article |
spelling |
doaj-500904f4b2d246bab4eadaa73b047dc12020-11-25T00:14:28ZengElsevierIndian Heart Journal0019-48322018-11-01706772776Prognostic value of hyperglycemia on-admission in diabetic versus non-diabetic patients presenting with ST-elevation myocardial infarction in TunisiaWalid Jomaa0Sana El Mhamdi1Imen Ben Ali2Mohamed A. Azaiez3Aymen El Hraiech4Khaldoun Ben Hamda5Faouzi Maatouk6Cardiology B Department, Fattouma Bourguiba University Hospital and University of Monastir, Monastir, Tunisia; Corresponding author at: Cardiology B Department, Fattouma Bourguiba University Hospital, Ave. 1er juin, 5000 Monastir, Tunisia.Department of Community Medicine, Faculty of Medicine of Monastir, University of Monastir, Monastir, TunisiaCardiology B Department, Fattouma Bourguiba University Hospital and University of Monastir, Monastir, TunisiaCardiology B Department, Fattouma Bourguiba University Hospital and University of Monastir, Monastir, TunisiaCardiology B Department, Fattouma Bourguiba University Hospital and University of Monastir, Monastir, TunisiaCardiology B Department, Fattouma Bourguiba University Hospital and University of Monastir, Monastir, TunisiaCardiology B Department, Fattouma Bourguiba University Hospital and University of Monastir, Monastir, TunisiaBackground: Hyperglycemia on-admission is a powerful predictor of adverse events in patients presenting for ST-elevation myocardial infarction (STEMI). Aim: In this study, we sought to determine the prognostic value of hyperglycemia on-admission in Tunisian patients presenting with STEMI according to their diabetic status. Methods: Patients presenting to our center between January 1998 and September 2014 were enrolled. Hyperglycemia was defined as a glucose level ≥11 mmol/L. In-hospital prognosis was studied in diabetic and non-diabetic patients. The predictive value for mortality of glycemia level on-admission was assessed by mean of the area under receiver operating characteristic (ROC) curve calculation. Results: A total of 1289 patients were included. Mean age was 60.39 ± 12.8 years and 977 (77.3%) patients were male. Prevalence of diabetes mellitus was 70.2% and 15.2% in patients presenting with and without hyperglycemia, respectively (p < 0.001). In univariate analysis, hyperglycemia was associated to in-hospital death in diabetic (OR: 8.85, 95% CI: 2.11–37.12, p < 0.001) and non-diabetic patients (OR: 2.57, 95% CI: 1.39–4.74, p = 0.002). In multivariate analysis, hyperglycemia was independently predictive of in-hospital death in diabetic patients (OR: 9.6, 95% CI: 2.18–42.22, p = 0.003) but not in non-diabetic patients (OR: 1.93, 95% CI: 0.97–3.86, p = 0.06). Area under ROC curve of glycemia as a predictor of in-hospital death was 0.792 in diabetic and 0.676 in non-diabetic patients. Conclusion: In patients presenting with STEMI, hyperglycemia was associated to hospital death in diabetic and non-diabetic patients in univariate analysis. In multivariate analysis, hyperglycemia was independently associated to in-hospital death in diabetic but not in non-diabetic patients. Keywords: Hyperglycemia, Diabetes mellitus, ST-elevation myocardial infarction, Mortalityhttp://www.sciencedirect.com/science/article/pii/S0019483217304224 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Walid Jomaa Sana El Mhamdi Imen Ben Ali Mohamed A. Azaiez Aymen El Hraiech Khaldoun Ben Hamda Faouzi Maatouk |
spellingShingle |
Walid Jomaa Sana El Mhamdi Imen Ben Ali Mohamed A. Azaiez Aymen El Hraiech Khaldoun Ben Hamda Faouzi Maatouk Prognostic value of hyperglycemia on-admission in diabetic versus non-diabetic patients presenting with ST-elevation myocardial infarction in Tunisia Indian Heart Journal |
author_facet |
Walid Jomaa Sana El Mhamdi Imen Ben Ali Mohamed A. Azaiez Aymen El Hraiech Khaldoun Ben Hamda Faouzi Maatouk |
author_sort |
Walid Jomaa |
title |
Prognostic value of hyperglycemia on-admission in diabetic versus non-diabetic patients presenting with ST-elevation myocardial infarction in Tunisia |
title_short |
Prognostic value of hyperglycemia on-admission in diabetic versus non-diabetic patients presenting with ST-elevation myocardial infarction in Tunisia |
title_full |
Prognostic value of hyperglycemia on-admission in diabetic versus non-diabetic patients presenting with ST-elevation myocardial infarction in Tunisia |
title_fullStr |
Prognostic value of hyperglycemia on-admission in diabetic versus non-diabetic patients presenting with ST-elevation myocardial infarction in Tunisia |
title_full_unstemmed |
Prognostic value of hyperglycemia on-admission in diabetic versus non-diabetic patients presenting with ST-elevation myocardial infarction in Tunisia |
title_sort |
prognostic value of hyperglycemia on-admission in diabetic versus non-diabetic patients presenting with st-elevation myocardial infarction in tunisia |
publisher |
Elsevier |
series |
Indian Heart Journal |
issn |
0019-4832 |
publishDate |
2018-11-01 |
description |
Background: Hyperglycemia on-admission is a powerful predictor of adverse events in patients presenting for ST-elevation myocardial infarction (STEMI). Aim: In this study, we sought to determine the prognostic value of hyperglycemia on-admission in Tunisian patients presenting with STEMI according to their diabetic status. Methods: Patients presenting to our center between January 1998 and September 2014 were enrolled. Hyperglycemia was defined as a glucose level ≥11 mmol/L. In-hospital prognosis was studied in diabetic and non-diabetic patients. The predictive value for mortality of glycemia level on-admission was assessed by mean of the area under receiver operating characteristic (ROC) curve calculation. Results: A total of 1289 patients were included. Mean age was 60.39 ± 12.8 years and 977 (77.3%) patients were male. Prevalence of diabetes mellitus was 70.2% and 15.2% in patients presenting with and without hyperglycemia, respectively (p < 0.001). In univariate analysis, hyperglycemia was associated to in-hospital death in diabetic (OR: 8.85, 95% CI: 2.11–37.12, p < 0.001) and non-diabetic patients (OR: 2.57, 95% CI: 1.39–4.74, p = 0.002). In multivariate analysis, hyperglycemia was independently predictive of in-hospital death in diabetic patients (OR: 9.6, 95% CI: 2.18–42.22, p = 0.003) but not in non-diabetic patients (OR: 1.93, 95% CI: 0.97–3.86, p = 0.06). Area under ROC curve of glycemia as a predictor of in-hospital death was 0.792 in diabetic and 0.676 in non-diabetic patients. Conclusion: In patients presenting with STEMI, hyperglycemia was associated to hospital death in diabetic and non-diabetic patients in univariate analysis. In multivariate analysis, hyperglycemia was independently associated to in-hospital death in diabetic but not in non-diabetic patients. Keywords: Hyperglycemia, Diabetes mellitus, ST-elevation myocardial infarction, Mortality |
url |
http://www.sciencedirect.com/science/article/pii/S0019483217304224 |
work_keys_str_mv |
AT walidjomaa prognosticvalueofhyperglycemiaonadmissionindiabeticversusnondiabeticpatientspresentingwithstelevationmyocardialinfarctionintunisia AT sanaelmhamdi prognosticvalueofhyperglycemiaonadmissionindiabeticversusnondiabeticpatientspresentingwithstelevationmyocardialinfarctionintunisia AT imenbenali prognosticvalueofhyperglycemiaonadmissionindiabeticversusnondiabeticpatientspresentingwithstelevationmyocardialinfarctionintunisia AT mohamedaazaiez prognosticvalueofhyperglycemiaonadmissionindiabeticversusnondiabeticpatientspresentingwithstelevationmyocardialinfarctionintunisia AT aymenelhraiech prognosticvalueofhyperglycemiaonadmissionindiabeticversusnondiabeticpatientspresentingwithstelevationmyocardialinfarctionintunisia AT khaldounbenhamda prognosticvalueofhyperglycemiaonadmissionindiabeticversusnondiabeticpatientspresentingwithstelevationmyocardialinfarctionintunisia AT faouzimaatouk prognosticvalueofhyperglycemiaonadmissionindiabeticversusnondiabeticpatientspresentingwithstelevationmyocardialinfarctionintunisia |
_version_ |
1725390296562270208 |