The factors predicting biochemical recurrence in patients with radical prostatectomy
Objective: The main objective of this study was to evaluate the factors predicting recurrence in patients who underwent radical prostatectomy (RP) for localized prostate cancer. Materials and Methods: A total of 275 patients who underwent RP between 2000 and 2012 years in our clinic were evaluated r...
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doaj-500bf358d7e4493484d17a2acf79739e2020-11-25T02:01:00ZengPAGEPress PublicationsArchivio Italiano di Urologia e Andrologia1124-35622282-41972016-01-0187427027510.4081/aiua.2015.4.2704581The factors predicting biochemical recurrence in patients with radical prostatectomyOsman Koca0Sıtkı Ün1Hakan Türk2Ferruh Zorlu3Urology Department, Horasan State Hospital, ErzurumUrology Department, Katip Çelebi University, Atatürk Research and Training Hospital, İzmirUrology Department, Tepecik Research and Training Hospital, İzmirUrology Department, Tepecik Research and Training Hospital, İzmirObjective: The main objective of this study was to evaluate the factors predicting recurrence in patients who underwent radical prostatectomy (RP) for localized prostate cancer. Materials and Methods: A total of 275 patients who underwent RP between 2000 and 2012 years in our clinic were evaluated retrospectively and 238 patients who met our criteria were included in the study. The effect of PSA values at diagnosis in addition the histopathological variables on the risk of recurrence was evaluated. Biochemical recurrence (BCR) is defined as “an increase of > 0.2 ng/ml or more in the serum total PSA count”. The statistical analysis of this study was done using SPSS for Windows Version 15.0 package program. Values below p < 0.05 are accepted as statistically significant. Results: The mean follow up, age and PSA of patients were 37,2 months, 66,01 ± 6,85 years and 11,12 ng/ml, respectively. BCR rate was 28% (68/238). Univariate analysis revealed that PSA levels during initial diagnosis (p < 0.0001), Gleason score (GS) (p < 0.0001), prostatic capsule involvement (p < 0.005), extracapsular extension (p = 0.0001), seminal vesicle involvement (p < 0.003) and surgical margin positivity (p < 0.014) were significant factors in predicting recurrence, while multivariate analysis showed that PSA at initial diagnosis (p = 0.002) and GS (p = 0.003) were independent prognostic factors. PSA > 10 ng/ml and Gleason score > 7 are considered as the risk factors for BCR. Conclusion: Our study results showed that PSA value during initial diagnosis as well as Gleason score were independent factors in predicting BCR following radical prostatectomy.http://www.pagepressjournals.org/index.php/aiua/article/view/5728Prostate cancerBiochemical recurrenceRadical prostatectomy |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Osman Koca Sıtkı Ün Hakan Türk Ferruh Zorlu |
spellingShingle |
Osman Koca Sıtkı Ün Hakan Türk Ferruh Zorlu The factors predicting biochemical recurrence in patients with radical prostatectomy Archivio Italiano di Urologia e Andrologia Prostate cancer Biochemical recurrence Radical prostatectomy |
author_facet |
Osman Koca Sıtkı Ün Hakan Türk Ferruh Zorlu |
author_sort |
Osman Koca |
title |
The factors predicting biochemical recurrence in patients with radical prostatectomy |
title_short |
The factors predicting biochemical recurrence in patients with radical prostatectomy |
title_full |
The factors predicting biochemical recurrence in patients with radical prostatectomy |
title_fullStr |
The factors predicting biochemical recurrence in patients with radical prostatectomy |
title_full_unstemmed |
The factors predicting biochemical recurrence in patients with radical prostatectomy |
title_sort |
factors predicting biochemical recurrence in patients with radical prostatectomy |
publisher |
PAGEPress Publications |
series |
Archivio Italiano di Urologia e Andrologia |
issn |
1124-3562 2282-4197 |
publishDate |
2016-01-01 |
description |
Objective: The main objective of this study was to evaluate the factors predicting recurrence in patients who underwent radical prostatectomy (RP) for localized prostate cancer. Materials and Methods: A total of 275 patients who underwent RP between 2000 and 2012 years in our clinic were evaluated retrospectively and 238 patients who met our criteria were included in the study. The effect of PSA values at diagnosis in addition the histopathological variables on the risk of recurrence was evaluated. Biochemical recurrence (BCR) is defined as “an increase of > 0.2 ng/ml or more in the serum total PSA count”. The statistical analysis of this study was done using SPSS for Windows Version 15.0 package program. Values below p < 0.05 are accepted as statistically significant. Results: The mean follow up, age and PSA of patients were 37,2 months, 66,01 ± 6,85 years and 11,12 ng/ml, respectively. BCR rate was 28% (68/238). Univariate analysis revealed that PSA levels during initial diagnosis (p < 0.0001), Gleason score (GS) (p < 0.0001), prostatic capsule involvement (p < 0.005), extracapsular extension (p = 0.0001), seminal vesicle involvement (p < 0.003) and surgical margin positivity (p < 0.014) were significant factors in predicting recurrence, while multivariate analysis showed that PSA at initial diagnosis (p = 0.002) and GS (p = 0.003) were independent prognostic factors. PSA > 10 ng/ml and Gleason score > 7 are considered as the risk factors for BCR. Conclusion: Our study results showed that PSA value during initial diagnosis as well as Gleason score were independent factors in predicting BCR following radical prostatectomy. |
topic |
Prostate cancer Biochemical recurrence Radical prostatectomy |
url |
http://www.pagepressjournals.org/index.php/aiua/article/view/5728 |
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