Autoimmune hemolytic anemia: transfusion challenges and solutions

• Main Authors: Barros MM, Langhi Jr DM, Bordin JO
• Format: Article
• Language: English
• Published: Dove Medical Press 2017-03-01
• Series: International Journal of Clinical Transfusion Medicine
• Subjects: Autoimmune Hemolytic Anemia; Transfusion; Rbc Antibodies
• Online Access: https://www.dovepress.com/autoimmune-hemolytic-anemia-transfusion-challenges-and-solutions-peer-reviewed-article-IJCTM

Melca M O Barros, Dante M Langhi Jr, José O Bordin Department of Clinical and Experimental Oncology, Universidade Federal de São Paulo, São Paulo, Brazil Abstract: Autoimmune hemolytic anemia (AIHA) is defined as the increased destruction of red blood cells (RBCs) in the presence of anti-RBC autoantibodies and/or complement. Classification of AIHA is based on the optimal auto-RBC antibody reactivity temperatures and includes warm, cold-reactive, mixed AIHA, and drug-induced AIHA subtypes. AIHA is a rare disease, and recommendations for transfusion are based mainly on results from retrospective data and relatively small cohort studies, including heterogeneous patient samples or single case reports. In this article, we will review the challenges and solutions to safely transfuse AIHA patients. We will reflect on the indication for transfusion in AIHA and the difficulty in the accomplishment of immunohematological procedures for the selection of the safest and most compatible RBC units. Keywords: hemolytic anemia, RBC autoantibodies, autoimmunity, hemolysis, direct ­antiglobulin test