Bone morphogenetic protein 7 promotes resistance to immunotherapy

The mechanisms underlying resistance to immunotherapy are still poorly understood. Here, the authors show that BMP7, a molecule part of the TGF-beta superfamily, suppresses proinflammatory antitumor responses and may represent a target for overcoming resistance to PD1 inhibitors.

Bibliographic Details
Main Authors:	Maria Angelica Cortez, Fatemeh Masrorpour, Cristina Ivan, Jie Zhang, Ahmed I. Younes, Yue Lu, Marcos R Estecio, Hampartsoum B. Barsoumian, Hari Menon, Mauricio da Silva Caetano, Rishab Ramapriyan, Jonathan E. Schoenhals, Xiaohong Wang, Ferdinandos Skoulidis, Mark D. Wasley, George Calin, Patrick Hwu, James W. Welsh
Format:	Article
Language:	English
Published:	Nature Publishing Group 2020-09-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-020-18617-z

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spelling	doaj-50194472a306497690c2c253af5c18082021-09-26T11:46:30ZengNature Publishing GroupNature Communications2041-17232020-09-0111111410.1038/s41467-020-18617-zBone morphogenetic protein 7 promotes resistance to immunotherapyMaria Angelica Cortez0Fatemeh Masrorpour1Cristina Ivan2Jie Zhang3Ahmed I. Younes4Yue Lu5Marcos R Estecio6Hampartsoum B. Barsoumian7Hari Menon8Mauricio da Silva Caetano9Rishab Ramapriyan10Jonathan E. Schoenhals11Xiaohong Wang12Ferdinandos Skoulidis13Mark D. Wasley14George Calin15Patrick Hwu16James W. Welsh17Departments of Radiation Oncology, The University of Texas MD Anderson Cancer CenterDepartments of Radiation Oncology, The University of Texas MD Anderson Cancer CenterExperimental Therapeutics, The University of Texas MD Anderson Cancer CenterExperimental Radiation Oncology, The University of Texas MD Anderson Cancer CenterDepartments of Radiation Oncology, The University of Texas MD Anderson Cancer CenterEpigenetic and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer CenterEpigenetic and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer CenterDepartments of Radiation Oncology, The University of Texas MD Anderson Cancer CenterDepartments of Radiation Oncology, The University of Texas MD Anderson Cancer CenterExperimental Radiation Oncology, The University of Texas MD Anderson Cancer CenterDepartments of Radiation Oncology, The University of Texas MD Anderson Cancer CenterExperimental Radiation Oncology, The University of Texas MD Anderson Cancer CenterExperimental Radiation Oncology, The University of Texas MD Anderson Cancer CenterThoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer CenterDepartments of Radiation Oncology, The University of Texas MD Anderson Cancer CenterExperimental Therapeutics, The University of Texas MD Anderson Cancer CenterMelanoma Medical Oncology, The University of Texas MD Anderson Cancer CenterDepartments of Radiation Oncology, The University of Texas MD Anderson Cancer CenterThe mechanisms underlying resistance to immunotherapy are still poorly understood. Here, the authors show that BMP7, a molecule part of the TGF-beta superfamily, suppresses proinflammatory antitumor responses and may represent a target for overcoming resistance to PD1 inhibitors.https://doi.org/10.1038/s41467-020-18617-z
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Maria Angelica Cortez Fatemeh Masrorpour Cristina Ivan Jie Zhang Ahmed I. Younes Yue Lu Marcos R Estecio Hampartsoum B. Barsoumian Hari Menon Mauricio da Silva Caetano Rishab Ramapriyan Jonathan E. Schoenhals Xiaohong Wang Ferdinandos Skoulidis Mark D. Wasley George Calin Patrick Hwu James W. Welsh
spellingShingle	Maria Angelica Cortez Fatemeh Masrorpour Cristina Ivan Jie Zhang Ahmed I. Younes Yue Lu Marcos R Estecio Hampartsoum B. Barsoumian Hari Menon Mauricio da Silva Caetano Rishab Ramapriyan Jonathan E. Schoenhals Xiaohong Wang Ferdinandos Skoulidis Mark D. Wasley George Calin Patrick Hwu James W. Welsh Bone morphogenetic protein 7 promotes resistance to immunotherapy Nature Communications
author_facet	Maria Angelica Cortez Fatemeh Masrorpour Cristina Ivan Jie Zhang Ahmed I. Younes Yue Lu Marcos R Estecio Hampartsoum B. Barsoumian Hari Menon Mauricio da Silva Caetano Rishab Ramapriyan Jonathan E. Schoenhals Xiaohong Wang Ferdinandos Skoulidis Mark D. Wasley George Calin Patrick Hwu James W. Welsh
author_sort	Maria Angelica Cortez
title	Bone morphogenetic protein 7 promotes resistance to immunotherapy
title_short	Bone morphogenetic protein 7 promotes resistance to immunotherapy
title_full	Bone morphogenetic protein 7 promotes resistance to immunotherapy
title_fullStr	Bone morphogenetic protein 7 promotes resistance to immunotherapy
title_full_unstemmed	Bone morphogenetic protein 7 promotes resistance to immunotherapy
title_sort	bone morphogenetic protein 7 promotes resistance to immunotherapy
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2020-09-01
description	The mechanisms underlying resistance to immunotherapy are still poorly understood. Here, the authors show that BMP7, a molecule part of the TGF-beta superfamily, suppresses proinflammatory antitumor responses and may represent a target for overcoming resistance to PD1 inhibitors.
url	https://doi.org/10.1038/s41467-020-18617-z
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Bone morphogenetic protein 7 promotes resistance to immunotherapy

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