Antiobesity Activity of <i>Elateriospermum tapos</i> Shell Extract in Obesity-Induced Sprague Dawley Rats
Obesity is one of the risk factors associated with cardiovascular diseases, hypertension, abnormal liver function, diabetes, and cancers. Orlistat is currently available to treat obesity, but it is associated with adverse side effects. Natural resources are widely used for obesity treatment. Hence,...
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doaj-501ff2a8d18f4f7eb8660fd9226014112021-01-10T00:03:34ZengMDPI AGMolecules1420-30492021-01-012632132110.3390/molecules26020321Antiobesity Activity of <i>Elateriospermum tapos</i> Shell Extract in Obesity-Induced Sprague Dawley RatsKokila Vani Perumal0Nor Liyana Ja’afar1Che Norma Mat Taib2Nurul Husna Shafie3Hasnah Bahari4Department of Human Anatomy, Universiti Putra Malaysia, Serdang 43400, Selangor, MalaysiaDepartment of Human Anatomy, Universiti Putra Malaysia, Serdang 43400, Selangor, MalaysiaDepartment of Human Anatomy, Universiti Putra Malaysia, Serdang 43400, Selangor, MalaysiaDepartment of Nutrition and Dietetics, Universiti Putra Malaysia, Serdang 43400, Selangor, MalaysiaDepartment of Human Anatomy, Universiti Putra Malaysia, Serdang 43400, Selangor, MalaysiaObesity is one of the risk factors associated with cardiovascular diseases, hypertension, abnormal liver function, diabetes, and cancers. Orlistat is currently available to treat obesity, but it is associated with adverse side effects. Natural resources are widely used for obesity treatment. Hence, this study aimed to investigate the anti-obesity activity of <i>Elateriospermum tapos</i> (<i>E. tapos</i>) shell extract in obesity induced Sprague Dawley rats. The rats’ obesity was induced by a high-fat (HF) diet made up of 50% standard rat pellet, 20% milk powder, 6% corn starch, and 24% ghee and a cafeteria (CAF) diet such as chicken rolls, salty biscuits, cakes, and cheese snacks. A hot aqueous method for the extraction of <i>E. tapos</i> shells was applied by using 500 mL of distilled water for about 24 h. Various dosages of <i>E. tapos</i> shell extract (10 mg/kg, 100 mg/kg, and 200 mg/kg) were used. At the end of the study, body weight, caloric intake, organ weight, lipid profile, lipoprotein lipase (LPL) activity, and histopathology analysis were carried out. <i>E. tapos</i> shell extract treated groups showed a reduction in body weight, positive lipid-lowering effect, decrements in triglyceride accumulation and LPL activity, and positive improvement in histopathology analysis. A dose of 200 mg/kg showed the most effective result compared to 10 mg/kg and 100 mg/kg doses.https://www.mdpi.com/1420-3049/26/2/321<i>Elateriospermum tapos</i>obesitycafeteria diethigh-fat diet |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Kokila Vani Perumal Nor Liyana Ja’afar Che Norma Mat Taib Nurul Husna Shafie Hasnah Bahari |
spellingShingle |
Kokila Vani Perumal Nor Liyana Ja’afar Che Norma Mat Taib Nurul Husna Shafie Hasnah Bahari Antiobesity Activity of <i>Elateriospermum tapos</i> Shell Extract in Obesity-Induced Sprague Dawley Rats Molecules <i>Elateriospermum tapos</i> obesity cafeteria diet high-fat diet |
author_facet |
Kokila Vani Perumal Nor Liyana Ja’afar Che Norma Mat Taib Nurul Husna Shafie Hasnah Bahari |
author_sort |
Kokila Vani Perumal |
title |
Antiobesity Activity of <i>Elateriospermum tapos</i> Shell Extract in Obesity-Induced Sprague Dawley Rats |
title_short |
Antiobesity Activity of <i>Elateriospermum tapos</i> Shell Extract in Obesity-Induced Sprague Dawley Rats |
title_full |
Antiobesity Activity of <i>Elateriospermum tapos</i> Shell Extract in Obesity-Induced Sprague Dawley Rats |
title_fullStr |
Antiobesity Activity of <i>Elateriospermum tapos</i> Shell Extract in Obesity-Induced Sprague Dawley Rats |
title_full_unstemmed |
Antiobesity Activity of <i>Elateriospermum tapos</i> Shell Extract in Obesity-Induced Sprague Dawley Rats |
title_sort |
antiobesity activity of <i>elateriospermum tapos</i> shell extract in obesity-induced sprague dawley rats |
publisher |
MDPI AG |
series |
Molecules |
issn |
1420-3049 |
publishDate |
2021-01-01 |
description |
Obesity is one of the risk factors associated with cardiovascular diseases, hypertension, abnormal liver function, diabetes, and cancers. Orlistat is currently available to treat obesity, but it is associated with adverse side effects. Natural resources are widely used for obesity treatment. Hence, this study aimed to investigate the anti-obesity activity of <i>Elateriospermum tapos</i> (<i>E. tapos</i>) shell extract in obesity induced Sprague Dawley rats. The rats’ obesity was induced by a high-fat (HF) diet made up of 50% standard rat pellet, 20% milk powder, 6% corn starch, and 24% ghee and a cafeteria (CAF) diet such as chicken rolls, salty biscuits, cakes, and cheese snacks. A hot aqueous method for the extraction of <i>E. tapos</i> shells was applied by using 500 mL of distilled water for about 24 h. Various dosages of <i>E. tapos</i> shell extract (10 mg/kg, 100 mg/kg, and 200 mg/kg) were used. At the end of the study, body weight, caloric intake, organ weight, lipid profile, lipoprotein lipase (LPL) activity, and histopathology analysis were carried out. <i>E. tapos</i> shell extract treated groups showed a reduction in body weight, positive lipid-lowering effect, decrements in triglyceride accumulation and LPL activity, and positive improvement in histopathology analysis. A dose of 200 mg/kg showed the most effective result compared to 10 mg/kg and 100 mg/kg doses. |
topic |
<i>Elateriospermum tapos</i> obesity cafeteria diet high-fat diet |
url |
https://www.mdpi.com/1420-3049/26/2/321 |
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