Acute Hypokalemia May Not Be an Effective Way to Sensitize the In Situ Canine Heart for Sparfloxacin-Induced Long QT Syndrome
Abstract.: Extents of the sparfloxacin (3 – 10 mg/kg, i.v.)-induced QT interval prolongation under normokalemic and hypokalemic conditions were assessed in halothane-anesthetized beagle dogs (n = 5). The hypokalemic condition was induced by an oral administration of furosemide (200 mg/kg per day) fo...
Main Authors: | Katsuyoshi Chiba, Atsushi Sugiyama, Kazuo Watanabe, Kiyoshi Takasuna, Keitaro Hashimoto |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2006-01-01
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Series: | Journal of Pharmacological Sciences |
Online Access: | http://www.sciencedirect.com/science/article/pii/S1347861319345438 |
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