Roles of 5,10-Methylenetetrahydrofolate Reductase C677T Polymorphisms in First-Episode, Drug-Naive Adult Patients With Depression

Roles of 5,10-Methylenetetrahydrofolate Reductase C677T Polymorphisms in First-Episode, Drug-Naive Adult Patients With Depression

5,10-Methylenetetrahydrofolate reductase (MTHFR) gene C677T polymorphism is considered as a predisposition and promising genetic candidate to major depressive disorder (MDD), as it is associated with impaired one-carbon cycles, which may be involved in the pathogenesis of depression. Cortical thickn...

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Bibliographic Details
Main Authors: Zhuoqing Li, Bo He, Jian Xu, Nan Dai, Liangliang Ping, Cong Zhou, Zonglin Shen, Xiufeng Xu, Yuqi Cheng
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-12-01
Series:Frontiers in Psychiatry
Subjects:
major depressive disorder
MTHFR C677T
cortical thickness
subcortical structure volume
anterior cingulate cortex
Online Access:https://www.frontiersin.org/articles/10.3389/fpsyt.2020.531959/full

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