Effects of Alpha Lipoic Acid Supplementation on Serum Levels of Oxidative Stress, Inflammatory Markers and Clinical Prognosis among Acute Ischemic Stroke Patients: A Randomized, Double Blind, TNS Trial
Purpose: Stroke is one of the most common conditions causing death. There have been few studies examining the effects of alpha lipoic acid (ALA) on stroke patients. In this regard, the present randomized controlled clinical trial was conducted to examine the effects of ALA supplementation on serum a...
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Tabriz University of Medical Sciences
2020-02-01
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doaj-502ce441b10648f1b609870395978c192020-11-25T03:20:35ZengTabriz University of Medical Sciences Advanced Pharmaceutical Bulletin2228-58812251-73082020-02-0110228428910.34172/apb.2020.034apb-27750Effects of Alpha Lipoic Acid Supplementation on Serum Levels of Oxidative Stress, Inflammatory Markers and Clinical Prognosis among Acute Ischemic Stroke Patients: A Randomized, Double Blind, TNS TrialSheyda Shaafi0Soraiya Ebrahimpour-Koujan1Mohammad Khalili2Seyad Morteza Shamshirgaran3Mazyar Hashemilar4Aliakbar Taheraghdam5Seyed Kazem Shakouri6Elyar Sadeghi Hokmabadi7Yaeghoub Ahmadi8Mehdi Farhoudi9Nasim Rezaeimanesh10Daryoush Savadi Osgouei11Department of Neurology, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.Students Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran.Multiple Sclerosis Research Center, Neuroscience institute, Tehran University of Medical Sciences, Tehran, Iran.Healthy Aging Research Center, Neyshabur University of Medical Sciences, Neyshabur, Iran.Department of Neurology, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.Department of Neurology, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.Physical Medicine and Rehabilitation Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.Department of Neurology, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.Department of Neurology, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.Department of Neurology, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.Multiple Sclerosis Research Center, Neuroscience institute, Tehran University of Medical Sciences, Tehran, Iran.Department of Neurology, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.Purpose: Stroke is one of the most common conditions causing death. There have been few studies examining the effects of alpha lipoic acid (ALA) on stroke patients. In this regard, the present randomized controlled clinical trial was conducted to examine the effects of ALA supplementation on serum albumin, and inflammatory and oxidative stress markers in stroke patients. Methods: The present paralleled randomized controlled clinical trial involved 42 stroke patients who were over 40 years and under enteral feeding. The participants were randomly assigned into two groups and finally 40 patients completed the study. Patients in alpha lipoic acid group (n=19) took 1200 mg ALA supplement daily along with their meal, and participants in control group (n=21) underwent the routine hospital diet for 3 weeks. Fasting blood samples were obtained and albumin, oxidative stress, and inflammatory indices were assessed at baseline, as well as at the end of the trial. Results: After 3 weeks, treatment of patients with ALA led to a significant decrease in tumor necrosis factor alpha (TNF-α) and interleukin 6 (IL-6) levels (P=0.01) compared to baseline. But serum levels of albumin, total antioxidant capacity (TAC), malondialdehyde (MDA), highsensitivity C-reactive protein (hs-CRP), IL-6 and TNF-α did not change significantly vs. control group (P>0.05). Conclusion: ALA did not significantly change the serum levels of albumin and inflammatory as well as antioxidant capacity indices in stroke patients compared with the control group. More clinical trials with large sample sizes and long duration are needed to clarify the effects of ALA on these patients.https://apb.tbzmed.ac.ir/PDF/apb-27750alpha lipoic acidinflammationoxidative stressstroke |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Sheyda Shaafi Soraiya Ebrahimpour-Koujan Mohammad Khalili Seyad Morteza Shamshirgaran Mazyar Hashemilar Aliakbar Taheraghdam Seyed Kazem Shakouri Elyar Sadeghi Hokmabadi Yaeghoub Ahmadi Mehdi Farhoudi Nasim Rezaeimanesh Daryoush Savadi Osgouei |
spellingShingle |
Sheyda Shaafi Soraiya Ebrahimpour-Koujan Mohammad Khalili Seyad Morteza Shamshirgaran Mazyar Hashemilar Aliakbar Taheraghdam Seyed Kazem Shakouri Elyar Sadeghi Hokmabadi Yaeghoub Ahmadi Mehdi Farhoudi Nasim Rezaeimanesh Daryoush Savadi Osgouei Effects of Alpha Lipoic Acid Supplementation on Serum Levels of Oxidative Stress, Inflammatory Markers and Clinical Prognosis among Acute Ischemic Stroke Patients: A Randomized, Double Blind, TNS Trial Advanced Pharmaceutical Bulletin alpha lipoic acid inflammation oxidative stress stroke |
author_facet |
Sheyda Shaafi Soraiya Ebrahimpour-Koujan Mohammad Khalili Seyad Morteza Shamshirgaran Mazyar Hashemilar Aliakbar Taheraghdam Seyed Kazem Shakouri Elyar Sadeghi Hokmabadi Yaeghoub Ahmadi Mehdi Farhoudi Nasim Rezaeimanesh Daryoush Savadi Osgouei |
author_sort |
Sheyda Shaafi |
title |
Effects of Alpha Lipoic Acid Supplementation on Serum Levels of Oxidative Stress, Inflammatory Markers and Clinical Prognosis among Acute Ischemic Stroke Patients: A Randomized, Double Blind, TNS Trial |
title_short |
Effects of Alpha Lipoic Acid Supplementation on Serum Levels of Oxidative Stress, Inflammatory Markers and Clinical Prognosis among Acute Ischemic Stroke Patients: A Randomized, Double Blind, TNS Trial |
title_full |
Effects of Alpha Lipoic Acid Supplementation on Serum Levels of Oxidative Stress, Inflammatory Markers and Clinical Prognosis among Acute Ischemic Stroke Patients: A Randomized, Double Blind, TNS Trial |
title_fullStr |
Effects of Alpha Lipoic Acid Supplementation on Serum Levels of Oxidative Stress, Inflammatory Markers and Clinical Prognosis among Acute Ischemic Stroke Patients: A Randomized, Double Blind, TNS Trial |
title_full_unstemmed |
Effects of Alpha Lipoic Acid Supplementation on Serum Levels of Oxidative Stress, Inflammatory Markers and Clinical Prognosis among Acute Ischemic Stroke Patients: A Randomized, Double Blind, TNS Trial |
title_sort |
effects of alpha lipoic acid supplementation on serum levels of oxidative stress, inflammatory markers and clinical prognosis among acute ischemic stroke patients: a randomized, double blind, tns trial |
publisher |
Tabriz University of Medical Sciences |
series |
Advanced Pharmaceutical Bulletin |
issn |
2228-5881 2251-7308 |
publishDate |
2020-02-01 |
description |
Purpose: Stroke is one of the most common conditions causing death. There have been few studies examining the effects of alpha lipoic acid (ALA) on stroke patients. In this regard, the present randomized controlled clinical trial was conducted to examine the effects of ALA supplementation on serum albumin, and inflammatory and oxidative stress markers in stroke patients. Methods: The present paralleled randomized controlled clinical trial involved 42 stroke patients who were over 40 years and under enteral feeding. The participants were randomly assigned into two groups and finally 40 patients completed the study. Patients in alpha lipoic acid group (n=19) took 1200 mg ALA supplement daily along with their meal, and participants in control group (n=21) underwent the routine hospital diet for 3 weeks. Fasting blood samples were obtained and albumin, oxidative stress, and inflammatory indices were assessed at baseline, as well as at the end of the trial. Results: After 3 weeks, treatment of patients with ALA led to a significant decrease in tumor necrosis factor alpha (TNF-α) and interleukin 6 (IL-6) levels (P=0.01) compared to baseline. But serum levels of albumin, total antioxidant capacity (TAC), malondialdehyde (MDA), highsensitivity C-reactive protein (hs-CRP), IL-6 and TNF-α did not change significantly vs. control group (P>0.05). Conclusion: ALA did not significantly change the serum levels of albumin and inflammatory as well as antioxidant capacity indices in stroke patients compared with the control group. More clinical trials with large sample sizes and long duration are needed to clarify the effects of ALA on these patients. |
topic |
alpha lipoic acid inflammation oxidative stress stroke |
url |
https://apb.tbzmed.ac.ir/PDF/apb-27750 |
work_keys_str_mv |
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