Trimodality PET/CT/MRI and Radiotherapy: A Mini-Review
Computed tomography (CT) has revolutionized external radiotherapy by making it possible to visualize and segment the tumors and the organs at risk in a three-dimensional way. However, if CT is a now a standard, it presents some limitations, notably concerning tumor characterization and delineation....
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doaj-502d6008a5494ad58a7530cfe23f01652021-02-04T05:40:33ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2021-02-011010.3389/fonc.2020.614008614008Trimodality PET/CT/MRI and Radiotherapy: A Mini-ReviewPierre Decazes0Pierre Decazes1Pauline Hinault2Ovidiu Veresezan3Sébastien Thureau4Sébastien Thureau5Sébastien Thureau6Pierrick Gouel7Pierrick Gouel8Pierre Vera9Pierre Vera10Nuclear Medicine Department, Henri Becquerel Cancer Center, Rouen, FranceQuantIF-LITIS EA4108, University of Rouen, Rouen, FranceQuantIF-LITIS EA4108, University of Rouen, Rouen, FranceRadiotherapy Department, Henri Becquerel Cancer Center, Rouen, FranceNuclear Medicine Department, Henri Becquerel Cancer Center, Rouen, FranceQuantIF-LITIS EA4108, University of Rouen, Rouen, FranceRadiotherapy Department, Henri Becquerel Cancer Center, Rouen, FranceNuclear Medicine Department, Henri Becquerel Cancer Center, Rouen, FranceQuantIF-LITIS EA4108, University of Rouen, Rouen, FranceNuclear Medicine Department, Henri Becquerel Cancer Center, Rouen, FranceQuantIF-LITIS EA4108, University of Rouen, Rouen, FranceComputed tomography (CT) has revolutionized external radiotherapy by making it possible to visualize and segment the tumors and the organs at risk in a three-dimensional way. However, if CT is a now a standard, it presents some limitations, notably concerning tumor characterization and delineation. Its association with functional and anatomical images, that are positron emission tomography (PET) and magnetic resonance imaging (MRI), surpasses its limits. This association can be in the form of a trimodality PET/CT/MRI. The objective of this mini-review is to describe the process of performing this PET/CT/MRI trimodality for radiotherapy and its potential clinical applications. Trimodality can be performed in two ways, either a PET/MRI fused to a planning CT (possibly with a pseudo-CT generated from the MRI for the planning), or a PET/CT fused to an MRI and then registered to a planning CT (possibly the CT of PET/CT if calibrated for radiotherapy). These examinations should be performed in the treatment position, and in the second case, a patient transfer system can be used between the PET/CT and MRI to limit movement. If trimodality requires adapted equipment, notably compatible MRI equipment with high-performance dedicated coils, it allows the advantages of the three techniques to be combined with a synergistic effect while limiting their disadvantages when carried out separately. Trimodality is already possible in clinical routine and can have a high clinical impact and good inter-observer agreement, notably for head and neck cancers, brain tumor, prostate cancer, cervical cancer.https://www.frontiersin.org/articles/10.3389/fonc.2020.614008/fullcomputed tomographymagnetic resonance imagingpositron emission tomographyradiotherapyhybrid imaging |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Pierre Decazes Pierre Decazes Pauline Hinault Ovidiu Veresezan Sébastien Thureau Sébastien Thureau Sébastien Thureau Pierrick Gouel Pierrick Gouel Pierre Vera Pierre Vera |
spellingShingle |
Pierre Decazes Pierre Decazes Pauline Hinault Ovidiu Veresezan Sébastien Thureau Sébastien Thureau Sébastien Thureau Pierrick Gouel Pierrick Gouel Pierre Vera Pierre Vera Trimodality PET/CT/MRI and Radiotherapy: A Mini-Review Frontiers in Oncology computed tomography magnetic resonance imaging positron emission tomography radiotherapy hybrid imaging |
author_facet |
Pierre Decazes Pierre Decazes Pauline Hinault Ovidiu Veresezan Sébastien Thureau Sébastien Thureau Sébastien Thureau Pierrick Gouel Pierrick Gouel Pierre Vera Pierre Vera |
author_sort |
Pierre Decazes |
title |
Trimodality PET/CT/MRI and Radiotherapy: A Mini-Review |
title_short |
Trimodality PET/CT/MRI and Radiotherapy: A Mini-Review |
title_full |
Trimodality PET/CT/MRI and Radiotherapy: A Mini-Review |
title_fullStr |
Trimodality PET/CT/MRI and Radiotherapy: A Mini-Review |
title_full_unstemmed |
Trimodality PET/CT/MRI and Radiotherapy: A Mini-Review |
title_sort |
trimodality pet/ct/mri and radiotherapy: a mini-review |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Oncology |
issn |
2234-943X |
publishDate |
2021-02-01 |
description |
Computed tomography (CT) has revolutionized external radiotherapy by making it possible to visualize and segment the tumors and the organs at risk in a three-dimensional way. However, if CT is a now a standard, it presents some limitations, notably concerning tumor characterization and delineation. Its association with functional and anatomical images, that are positron emission tomography (PET) and magnetic resonance imaging (MRI), surpasses its limits. This association can be in the form of a trimodality PET/CT/MRI. The objective of this mini-review is to describe the process of performing this PET/CT/MRI trimodality for radiotherapy and its potential clinical applications. Trimodality can be performed in two ways, either a PET/MRI fused to a planning CT (possibly with a pseudo-CT generated from the MRI for the planning), or a PET/CT fused to an MRI and then registered to a planning CT (possibly the CT of PET/CT if calibrated for radiotherapy). These examinations should be performed in the treatment position, and in the second case, a patient transfer system can be used between the PET/CT and MRI to limit movement. If trimodality requires adapted equipment, notably compatible MRI equipment with high-performance dedicated coils, it allows the advantages of the three techniques to be combined with a synergistic effect while limiting their disadvantages when carried out separately. Trimodality is already possible in clinical routine and can have a high clinical impact and good inter-observer agreement, notably for head and neck cancers, brain tumor, prostate cancer, cervical cancer. |
topic |
computed tomography magnetic resonance imaging positron emission tomography radiotherapy hybrid imaging |
url |
https://www.frontiersin.org/articles/10.3389/fonc.2020.614008/full |
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