Serum anti-Müllerian hormone concentrations before and after treatment of an ovarian granulosa cell tumour in a cat
Case summary A 15-year-old female cat was presented for investigation of progressive behavioural changes, polyuria, polydipsia and periuria. An ovarian granulosa cell tumour was identified and the cat underwent therapeutic ovariohysterectomy (OHE). The cat’s clinical signs resolved, but 6 months lat...
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doaj-504b00d54e264be48ee710940315969d2020-11-25T03:40:13ZengSAGE PublishingJournal of Feline Medicine and Surgery Open Reports2055-11692017-08-01310.1177/2055116917722701Serum anti-Müllerian hormone concentrations before and after treatment of an ovarian granulosa cell tumour in a catLaura A Heaps0Christopher J Scudder1Vicky J Lipscomb2Sarah ML Steinbach3Simon L Priestnall4Henny Martineau5Balazs Szladovits6Robert C Fowkes7Oliver A Garden8Department of Clinical Science and Services, Royal Veterinary College, North Mymms, UKEndocrine Signalling Group, Comparative Biomedical Sciences, Royal Veterinary College, London, UKDepartment of Clinical Science and Services, Royal Veterinary College, North Mymms, UKDepartment of Veterinary Clinical Sciences, College of Veterinary Medicine, Purdue University, West Lafayette, IN, USAPathobiology and Population Sciences, Royal Veterinary College, North Mymms, UKPathobiology and Population Sciences, Royal Veterinary College, North Mymms, UKPathobiology and Population Sciences, Royal Veterinary College, North Mymms, UKEndocrine Signalling Group, Comparative Biomedical Sciences, Royal Veterinary College, London, UKDepartment of Clinical Science and Services, Royal Veterinary College, North Mymms, UKCase summary A 15-year-old female cat was presented for investigation of progressive behavioural changes, polyuria, polydipsia and periuria. An ovarian granulosa cell tumour was identified and the cat underwent therapeutic ovariohysterectomy (OHE). The cat’s clinical signs resolved, but 6 months later it was diagnosed as having an anaplastic astrocytoma and was euthanased. Serum anti-Müllerian hormone (AMH) concentration prior to OHE was increased vs a control group of entire and neutered female cats. Following OHE, serum AMH concentration decreased to <1% of the original value. Relevance and novel information Serum AMH measurement may represent a novel diagnostic and monitoring tool for functional ovarian neoplasms in cats.https://doi.org/10.1177/2055116917722701 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Laura A Heaps Christopher J Scudder Vicky J Lipscomb Sarah ML Steinbach Simon L Priestnall Henny Martineau Balazs Szladovits Robert C Fowkes Oliver A Garden |
spellingShingle |
Laura A Heaps Christopher J Scudder Vicky J Lipscomb Sarah ML Steinbach Simon L Priestnall Henny Martineau Balazs Szladovits Robert C Fowkes Oliver A Garden Serum anti-Müllerian hormone concentrations before and after treatment of an ovarian granulosa cell tumour in a cat Journal of Feline Medicine and Surgery Open Reports |
author_facet |
Laura A Heaps Christopher J Scudder Vicky J Lipscomb Sarah ML Steinbach Simon L Priestnall Henny Martineau Balazs Szladovits Robert C Fowkes Oliver A Garden |
author_sort |
Laura A Heaps |
title |
Serum anti-Müllerian hormone concentrations before and after treatment of an ovarian granulosa cell tumour in a cat |
title_short |
Serum anti-Müllerian hormone concentrations before and after treatment of an ovarian granulosa cell tumour in a cat |
title_full |
Serum anti-Müllerian hormone concentrations before and after treatment of an ovarian granulosa cell tumour in a cat |
title_fullStr |
Serum anti-Müllerian hormone concentrations before and after treatment of an ovarian granulosa cell tumour in a cat |
title_full_unstemmed |
Serum anti-Müllerian hormone concentrations before and after treatment of an ovarian granulosa cell tumour in a cat |
title_sort |
serum anti-müllerian hormone concentrations before and after treatment of an ovarian granulosa cell tumour in a cat |
publisher |
SAGE Publishing |
series |
Journal of Feline Medicine and Surgery Open Reports |
issn |
2055-1169 |
publishDate |
2017-08-01 |
description |
Case summary A 15-year-old female cat was presented for investigation of progressive behavioural changes, polyuria, polydipsia and periuria. An ovarian granulosa cell tumour was identified and the cat underwent therapeutic ovariohysterectomy (OHE). The cat’s clinical signs resolved, but 6 months later it was diagnosed as having an anaplastic astrocytoma and was euthanased. Serum anti-Müllerian hormone (AMH) concentration prior to OHE was increased vs a control group of entire and neutered female cats. Following OHE, serum AMH concentration decreased to <1% of the original value. Relevance and novel information Serum AMH measurement may represent a novel diagnostic and monitoring tool for functional ovarian neoplasms in cats. |
url |
https://doi.org/10.1177/2055116917722701 |
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