Dynamic changes of neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio predicts breast cancer prognosis
Abstract Background We aimed to identify whether neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) are more useful predictors after initial intention to treat than at the time of diagnosis. Methods We collected the medical data of 533 patients. The results of the peripheral...
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doaj-504c2414f72049679e117142f23a20742020-12-08T14:03:27ZengBMCBMC Cancer1471-24072020-12-012011810.1186/s12885-020-07700-9Dynamic changes of neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio predicts breast cancer prognosisJu-Yeon Kim0Eun Jung Jung1Jae-Myung Kim2Han Shin Lee3Seung-Jin Kwag4Ji-Ho Park5Taejin Park6Sang-Ho Jeong7Chi-Young Jeong8Young-Tae Ju9Department of Surgery, Gyeongsang National University School of Medicine and Gyeongsang National University HospitalDepartment of Surgery, Gyeongsang National University School of Medicine and Gyeongsang National University Changwon HospitalDepartment of Surgery, Gyeongsang National University School of Medicine and Gyeongsang National University HospitalDepartment of Surgery, Gyeongsang National University School of Medicine and Gyeongsang National University Changwon HospitalDepartment of Surgery, Gyeongsang National University School of Medicine and Gyeongsang National University HospitalDepartment of Surgery, Gyeongsang National University School of Medicine and Gyeongsang National University HospitalDepartment of Surgery, Gyeongsang National University School of Medicine and Gyeongsang National University Changwon HospitalDepartment of Surgery, Gyeongsang National University School of Medicine and Gyeongsang National University Changwon HospitalDepartment of Surgery, Gyeongsang National University School of Medicine and Gyeongsang National University HospitalDepartment of Surgery, Gyeongsang National University School of Medicine and Gyeongsang National University HospitalAbstract Background We aimed to identify whether neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) are more useful predictors after initial intention to treat than at the time of diagnosis. Methods We collected the medical data of 533 patients. The results of the peripheral blood sampling before the primary treatments were labeled as initial cohort, and those obtained between 24 and 36 months after initial treatment were defined as the 2nd cohort. Delayed metastasis has been defined as distant metastasis 2 years after treatment, and survival outcome was estimated and compared across groups. Results Median follow-up duration was 74 months (24–162 months), and 53 patients experienced delayed metastasis. In univariate analysis, metastasis-free survival, patient age at diagnosis, tumor size, axillary lymph node metastasis, HER-2 status, initial NLR and PLR, and 2nd NLR and PLR were found to be significantly associated with delayed metastasis. However, in multivariate analysis, only the 2nd NLR and PLR were found to be significantly associated with delayed metastasis, excluding initial NLR and PLR. Metastasis-free survival was analyzed through the pattern changes of NLR or PLR. The results revealed that patients with continued low NLR and PLR values at pre- and post-treatment (low initial values and 2nd values) showed a significantly better prognosis than those with a change in value or continued high NLR and PLR. Conclusions We identified that patients with persistent high NLR and PLR after initial treatment have significant worse prognosis in terms of late metastasis. Therefore, these results suggest that NLR and PLR are more useful in predicting prognosis post-treatment.https://doi.org/10.1186/s12885-020-07700-9Neutrophil-to-lymphocyte ratioPlatelet-to-lymphocyte ratioPrognostic factorBiomarker |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ju-Yeon Kim Eun Jung Jung Jae-Myung Kim Han Shin Lee Seung-Jin Kwag Ji-Ho Park Taejin Park Sang-Ho Jeong Chi-Young Jeong Young-Tae Ju |
spellingShingle |
Ju-Yeon Kim Eun Jung Jung Jae-Myung Kim Han Shin Lee Seung-Jin Kwag Ji-Ho Park Taejin Park Sang-Ho Jeong Chi-Young Jeong Young-Tae Ju Dynamic changes of neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio predicts breast cancer prognosis BMC Cancer Neutrophil-to-lymphocyte ratio Platelet-to-lymphocyte ratio Prognostic factor Biomarker |
author_facet |
Ju-Yeon Kim Eun Jung Jung Jae-Myung Kim Han Shin Lee Seung-Jin Kwag Ji-Ho Park Taejin Park Sang-Ho Jeong Chi-Young Jeong Young-Tae Ju |
author_sort |
Ju-Yeon Kim |
title |
Dynamic changes of neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio predicts breast cancer prognosis |
title_short |
Dynamic changes of neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio predicts breast cancer prognosis |
title_full |
Dynamic changes of neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio predicts breast cancer prognosis |
title_fullStr |
Dynamic changes of neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio predicts breast cancer prognosis |
title_full_unstemmed |
Dynamic changes of neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio predicts breast cancer prognosis |
title_sort |
dynamic changes of neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio predicts breast cancer prognosis |
publisher |
BMC |
series |
BMC Cancer |
issn |
1471-2407 |
publishDate |
2020-12-01 |
description |
Abstract Background We aimed to identify whether neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) are more useful predictors after initial intention to treat than at the time of diagnosis. Methods We collected the medical data of 533 patients. The results of the peripheral blood sampling before the primary treatments were labeled as initial cohort, and those obtained between 24 and 36 months after initial treatment were defined as the 2nd cohort. Delayed metastasis has been defined as distant metastasis 2 years after treatment, and survival outcome was estimated and compared across groups. Results Median follow-up duration was 74 months (24–162 months), and 53 patients experienced delayed metastasis. In univariate analysis, metastasis-free survival, patient age at diagnosis, tumor size, axillary lymph node metastasis, HER-2 status, initial NLR and PLR, and 2nd NLR and PLR were found to be significantly associated with delayed metastasis. However, in multivariate analysis, only the 2nd NLR and PLR were found to be significantly associated with delayed metastasis, excluding initial NLR and PLR. Metastasis-free survival was analyzed through the pattern changes of NLR or PLR. The results revealed that patients with continued low NLR and PLR values at pre- and post-treatment (low initial values and 2nd values) showed a significantly better prognosis than those with a change in value or continued high NLR and PLR. Conclusions We identified that patients with persistent high NLR and PLR after initial treatment have significant worse prognosis in terms of late metastasis. Therefore, these results suggest that NLR and PLR are more useful in predicting prognosis post-treatment. |
topic |
Neutrophil-to-lymphocyte ratio Platelet-to-lymphocyte ratio Prognostic factor Biomarker |
url |
https://doi.org/10.1186/s12885-020-07700-9 |
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