Spike Proteins of SARS-CoV and SARS-CoV-2 Utilize Different Mechanisms to Bind With Human ACE2

Spike Proteins of SARS-CoV and SARS-CoV-2 Utilize Different Mechanisms to Bind With Human ACE2

The ongoing outbreak of COVID-19 has been a serious threat to human health worldwide. The virus SARS-CoV-2 initiates its infection to the human body via the interaction of its spike (S) protein with the human Angiotensin-Converting Enzyme 2 (ACE2) of the host cells. Therefore, understanding the fund...

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Bibliographic Details
Main Authors: Yixin Xie, Chitra B. Karki, Dan Du, Haotian Li, Jun Wang, Adebiyi Sobitan, Shaolei Teng, Qiyi Tang, Lin Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-12-01
Series:Frontiers in Molecular Biosciences
Subjects:
ACE2
angiotensin-converting enzyme 2
protein- protein interactions
molecular dynamic
spike protein
SARS
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2020.591873/full

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