The Neuroprotective Role of Acupuncture and Activation of the BDNF Signaling Pathway
Recent studies have been conducted to examine the neuroprotective effects of acupuncture in many neurological disorders. Although the neuroprotective effects of acupuncture has been linked to changes in signaling pathways, accumulating evidence suggest the participation of endogenous biological medi...
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doaj-506038ccc3454fa7bc80490dd8cc3bc52020-11-24T23:55:14ZengMDPI AGInternational Journal of Molecular Sciences1422-00672014-02-011523234325210.3390/ijms15023234ijms15023234The Neuroprotective Role of Acupuncture and Activation of the BDNF Signaling PathwayDong Lin0Ike De La Pena1Lili Lin2Shu-Feng Zhou3Cesar V. Borlongan4Chuanhai Cao5College of acupuncture, Fujian University of Traditional Chinese Medicine, Minhou Shangjie, Fuzhou 350122, Fujian, ChinaDepartment of Neurosurgery and Brain Repair, College of Medicine, University of South Florida, Tampa, FL 33612, USACollege of acupuncture, Fujian University of Traditional Chinese Medicine, Minhou Shangjie, Fuzhou 350122, Fujian, ChinaCollege of pharmacy, Department of pharmaceutical Sciences, University of South Florida, Tampa, FL 33612, USADepartment of Neurosurgery and Brain Repair, College of Medicine, University of South Florida, Tampa, FL 33612, USACollege of pharmacy, Department of pharmaceutical Sciences, University of South Florida, Tampa, FL 33612, USARecent studies have been conducted to examine the neuroprotective effects of acupuncture in many neurological disorders. Although the neuroprotective effects of acupuncture has been linked to changes in signaling pathways, accumulating evidence suggest the participation of endogenous biological mediators, such as the neurotrophin (NT) family of proteins, specifically, the brain derived neurotrophic factor (BDNF). Accordingly, acupuncture can inhibit neurodegeneration via expression and activation of BDNF. Moreover, recent studies have reported that acupuncture can increase ATP levels at local stimulated points. We have also demonstrated that acupuncture could activate monocytes and increase the expression of BDNF via the stimulation of ATP. The purpose of this article is to review the recent findings and ongoing studies on the neuroprotective roles of acupuncture and therapeutic implications of acupuncture-induced activation of BDNF and its signaling pathway.http://www.mdpi.com/1422-0067/15/2/3234acupuncturebrain derived neurotrophic factorneuroprotectivecyclophilin A |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Dong Lin Ike De La Pena Lili Lin Shu-Feng Zhou Cesar V. Borlongan Chuanhai Cao |
spellingShingle |
Dong Lin Ike De La Pena Lili Lin Shu-Feng Zhou Cesar V. Borlongan Chuanhai Cao The Neuroprotective Role of Acupuncture and Activation of the BDNF Signaling Pathway International Journal of Molecular Sciences acupuncture brain derived neurotrophic factor neuroprotective cyclophilin A |
author_facet |
Dong Lin Ike De La Pena Lili Lin Shu-Feng Zhou Cesar V. Borlongan Chuanhai Cao |
author_sort |
Dong Lin |
title |
The Neuroprotective Role of Acupuncture and Activation of the BDNF Signaling Pathway |
title_short |
The Neuroprotective Role of Acupuncture and Activation of the BDNF Signaling Pathway |
title_full |
The Neuroprotective Role of Acupuncture and Activation of the BDNF Signaling Pathway |
title_fullStr |
The Neuroprotective Role of Acupuncture and Activation of the BDNF Signaling Pathway |
title_full_unstemmed |
The Neuroprotective Role of Acupuncture and Activation of the BDNF Signaling Pathway |
title_sort |
neuroprotective role of acupuncture and activation of the bdnf signaling pathway |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1422-0067 |
publishDate |
2014-02-01 |
description |
Recent studies have been conducted to examine the neuroprotective effects of acupuncture in many neurological disorders. Although the neuroprotective effects of acupuncture has been linked to changes in signaling pathways, accumulating evidence suggest the participation of endogenous biological mediators, such as the neurotrophin (NT) family of proteins, specifically, the brain derived neurotrophic factor (BDNF). Accordingly, acupuncture can inhibit neurodegeneration via expression and activation of BDNF. Moreover, recent studies have reported that acupuncture can increase ATP levels at local stimulated points. We have also demonstrated that acupuncture could activate monocytes and increase the expression of BDNF via the stimulation of ATP. The purpose of this article is to review the recent findings and ongoing studies on the neuroprotective roles of acupuncture and therapeutic implications of acupuncture-induced activation of BDNF and its signaling pathway. |
topic |
acupuncture brain derived neurotrophic factor neuroprotective cyclophilin A |
url |
http://www.mdpi.com/1422-0067/15/2/3234 |
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