Diffuse reflectance spectroscopy as a potential method for nonmelanoma skin cancer margin assessment
Abstract The standard‐of‐care for nonmelanoma skin cancer (NMSC), including basal cell carcinoma (BCC) and squamous cell carcinoma (SCC), is surgical excision of the tumor. To ensure removal of the entire tumor and minimize removal of healthy tissue, a tool for quick discrimination between cancerous...
Main Authors: | , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Wiley-VCH
2020-08-01
|
Series: | Translational Biophotonics |
Subjects: | |
Online Access: | https://doi.org/10.1002/tbio.202000001 |
id |
doaj-5066b44bf3b545249282e207952f703e |
---|---|
record_format |
Article |
spelling |
doaj-5066b44bf3b545249282e207952f703e2021-04-12T02:40:25ZengWiley-VCHTranslational Biophotonics2627-18502020-08-0123n/an/a10.1002/tbio.202000001Diffuse reflectance spectroscopy as a potential method for nonmelanoma skin cancer margin assessmentYao Zhang0Austin J. Moy1Xu Feng2Hieu T. M. Nguyen3Katherine R. Sebastian4Jason S. Reichenberg5Mia K. Markey6James W. Tunnell7Department of Biomedical Engineering The University of Texas at Austin Austin Texas USADepartment of Biomedical Engineering The University of Texas at Austin Austin Texas USADepartment of Biomedical Engineering The University of Texas at Austin Austin Texas USADepartment of Biomedical Engineering The University of Texas at Austin Austin Texas USADepartment of Medicine The University of Texas at Austin Austin Texas USADepartment of Medicine The University of Texas at Austin Austin Texas USADepartment of Biomedical Engineering The University of Texas at Austin Austin Texas USADepartment of Biomedical Engineering The University of Texas at Austin Austin Texas USAAbstract The standard‐of‐care for nonmelanoma skin cancer (NMSC), including basal cell carcinoma (BCC) and squamous cell carcinoma (SCC), is surgical excision of the tumor. To ensure removal of the entire tumor and minimize removal of healthy tissue, a tool for quick discrimination between cancerous and normal skin is needed. We propose using diffuse reflectance spectroscopy (DRS) to assess tumor margins. We collected two independent clinical datasets. Using a clinical study of 31 patients with 50 NMSC lesions, we trained models including DRS data normalization, a physiological model, parameter selection and logistic regression classifiers. We tested our models on a second clinical dataset of 56 patients with 68 NMSC lesions. Our test results showed the area under the ROC curve of 0.94 for BCC vs normal and 0.90 for SCC vs normal. When applying a threshold selected using the training dataset to the test dataset, for BCC vs normal, specificity is 89% and sensitivity is 87%; for SCC vs normal, specificity is 65% and sensitivity is 97%. This study indicates that DRS can be potentially used to map the tumor margin prior to surgery and monitor margins during the surgery on the surface of the skin.https://doi.org/10.1002/tbio.202000001classificationdiffuse reflectance spectroscopyphysiological modelskin cancertumor margin assessment |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yao Zhang Austin J. Moy Xu Feng Hieu T. M. Nguyen Katherine R. Sebastian Jason S. Reichenberg Mia K. Markey James W. Tunnell |
spellingShingle |
Yao Zhang Austin J. Moy Xu Feng Hieu T. M. Nguyen Katherine R. Sebastian Jason S. Reichenberg Mia K. Markey James W. Tunnell Diffuse reflectance spectroscopy as a potential method for nonmelanoma skin cancer margin assessment Translational Biophotonics classification diffuse reflectance spectroscopy physiological model skin cancer tumor margin assessment |
author_facet |
Yao Zhang Austin J. Moy Xu Feng Hieu T. M. Nguyen Katherine R. Sebastian Jason S. Reichenberg Mia K. Markey James W. Tunnell |
author_sort |
Yao Zhang |
title |
Diffuse reflectance spectroscopy as a potential method for nonmelanoma skin cancer margin assessment |
title_short |
Diffuse reflectance spectroscopy as a potential method for nonmelanoma skin cancer margin assessment |
title_full |
Diffuse reflectance spectroscopy as a potential method for nonmelanoma skin cancer margin assessment |
title_fullStr |
Diffuse reflectance spectroscopy as a potential method for nonmelanoma skin cancer margin assessment |
title_full_unstemmed |
Diffuse reflectance spectroscopy as a potential method for nonmelanoma skin cancer margin assessment |
title_sort |
diffuse reflectance spectroscopy as a potential method for nonmelanoma skin cancer margin assessment |
publisher |
Wiley-VCH |
series |
Translational Biophotonics |
issn |
2627-1850 |
publishDate |
2020-08-01 |
description |
Abstract The standard‐of‐care for nonmelanoma skin cancer (NMSC), including basal cell carcinoma (BCC) and squamous cell carcinoma (SCC), is surgical excision of the tumor. To ensure removal of the entire tumor and minimize removal of healthy tissue, a tool for quick discrimination between cancerous and normal skin is needed. We propose using diffuse reflectance spectroscopy (DRS) to assess tumor margins. We collected two independent clinical datasets. Using a clinical study of 31 patients with 50 NMSC lesions, we trained models including DRS data normalization, a physiological model, parameter selection and logistic regression classifiers. We tested our models on a second clinical dataset of 56 patients with 68 NMSC lesions. Our test results showed the area under the ROC curve of 0.94 for BCC vs normal and 0.90 for SCC vs normal. When applying a threshold selected using the training dataset to the test dataset, for BCC vs normal, specificity is 89% and sensitivity is 87%; for SCC vs normal, specificity is 65% and sensitivity is 97%. This study indicates that DRS can be potentially used to map the tumor margin prior to surgery and monitor margins during the surgery on the surface of the skin. |
topic |
classification diffuse reflectance spectroscopy physiological model skin cancer tumor margin assessment |
url |
https://doi.org/10.1002/tbio.202000001 |
work_keys_str_mv |
AT yaozhang diffusereflectancespectroscopyasapotentialmethodfornonmelanomaskincancermarginassessment AT austinjmoy diffusereflectancespectroscopyasapotentialmethodfornonmelanomaskincancermarginassessment AT xufeng diffusereflectancespectroscopyasapotentialmethodfornonmelanomaskincancermarginassessment AT hieutmnguyen diffusereflectancespectroscopyasapotentialmethodfornonmelanomaskincancermarginassessment AT katherinersebastian diffusereflectancespectroscopyasapotentialmethodfornonmelanomaskincancermarginassessment AT jasonsreichenberg diffusereflectancespectroscopyasapotentialmethodfornonmelanomaskincancermarginassessment AT miakmarkey diffusereflectancespectroscopyasapotentialmethodfornonmelanomaskincancermarginassessment AT jameswtunnell diffusereflectancespectroscopyasapotentialmethodfornonmelanomaskincancermarginassessment |
_version_ |
1721530460555706368 |