Linking low docosahexaenoic acid intake to Alzheimer’s disease: caution recommended
Prospective cohort studies and animal models support the concept that low docosahexaenoic acid intake is implicated in the etiology or progression of Alzheimer’s disease. However, other studies crucial to this relationship are less encouraging. To date, the few trials using docosahexaenoic acid to t...
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EDP Sciences
2007-05-01
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Online Access: | http://dx.doi.org/10.1051/ocl.2007.0118 |
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doaj-506889271ffc4abd869a1c4d6ca934fd2021-04-02T04:15:30ZengEDP SciencesOléagineux, Corps gras, Lipides1258-82101950-697X2007-05-01143-417718110.1051/ocl.2007.0118ocl2007143-4p177Linking low docosahexaenoic acid intake to Alzheimer’s disease: caution recommendedCunnane Stephen C.Plourde MélanieVandal MilèneFreemantle ErikaTremblay-Mercier JenniferBégin MichelProspective cohort studies and animal models support the concept that low docosahexaenoic acid intake is implicated in the etiology or progression of Alzheimer’s disease. However, other studies crucial to this relationship are less encouraging. To date, the few trials using docosahexaenoic acid to treat declining cognition in the elderly have either been very small or, in the largest trial, the beneficial effect was mild and limited to a sub-group of patients. The supplements used in each of these clinical trials contained at least one polyunsaturated fatty acid other than docosahexaenoic acid, so the active ingredient remains unclear. One widely cited study reported markedly lower brain docosahexaenoic acid in Alzheimer’s disease but at least five other much less commonly cited reports have not corroborated this effect. There are numerous inconsistencies or confounders in the data and several challenges to overcome before definitively attributing a specific role to docosahexaenoic acid in the protection of c ognitive function in the elderly.http://dx.doi.org/10.1051/ocl.2007.0118docosahexaenoic acidAlzheimer’s diseaseomega 3 fatty acidsbraineicosapentaenoic acidarachidonic acid |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Cunnane Stephen C. Plourde Mélanie Vandal Milène Freemantle Erika Tremblay-Mercier Jennifer Bégin Michel |
spellingShingle |
Cunnane Stephen C. Plourde Mélanie Vandal Milène Freemantle Erika Tremblay-Mercier Jennifer Bégin Michel Linking low docosahexaenoic acid intake to Alzheimer’s disease: caution recommended Oléagineux, Corps gras, Lipides docosahexaenoic acid Alzheimer’s disease omega 3 fatty acids brain eicosapentaenoic acid arachidonic acid |
author_facet |
Cunnane Stephen C. Plourde Mélanie Vandal Milène Freemantle Erika Tremblay-Mercier Jennifer Bégin Michel |
author_sort |
Cunnane Stephen C. |
title |
Linking low docosahexaenoic acid intake to Alzheimer’s disease: caution recommended |
title_short |
Linking low docosahexaenoic acid intake to Alzheimer’s disease: caution recommended |
title_full |
Linking low docosahexaenoic acid intake to Alzheimer’s disease: caution recommended |
title_fullStr |
Linking low docosahexaenoic acid intake to Alzheimer’s disease: caution recommended |
title_full_unstemmed |
Linking low docosahexaenoic acid intake to Alzheimer’s disease: caution recommended |
title_sort |
linking low docosahexaenoic acid intake to alzheimer’s disease: caution recommended |
publisher |
EDP Sciences |
series |
Oléagineux, Corps gras, Lipides |
issn |
1258-8210 1950-697X |
publishDate |
2007-05-01 |
description |
Prospective cohort studies and animal models support the concept that low docosahexaenoic acid intake is implicated in the etiology or progression of Alzheimer’s disease. However, other studies crucial to this relationship are less encouraging. To date, the few trials using docosahexaenoic acid to treat declining cognition in the elderly have either been very small or, in the largest trial, the beneficial effect was mild and limited to a sub-group of patients. The supplements used in each of these clinical trials contained at least one polyunsaturated fatty acid other than docosahexaenoic acid, so the active ingredient remains unclear. One widely cited study reported markedly lower brain docosahexaenoic acid in Alzheimer’s disease but at least five other much less commonly cited reports have not corroborated this effect. There are numerous inconsistencies or confounders in the data and several challenges to overcome before definitively attributing a specific role to docosahexaenoic acid in the protection of c ognitive function in the elderly. |
topic |
docosahexaenoic acid Alzheimer’s disease omega 3 fatty acids brain eicosapentaenoic acid arachidonic acid |
url |
http://dx.doi.org/10.1051/ocl.2007.0118 |
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