Gray Matter Changes in the Orbitofrontal-Paralimbic Cortex in Male Youths With Non-comorbid Conduct Disorder
Conduct disorder is one of the most common developmental psychiatric disorders which is characterized by persistent aggressive and antisocial behaviors during childhood or adolescence. Previous neuroimaging studies have investigated the neural correlates underlying CD and demonstrated several constr...
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Frontiers Media S.A.
2020-05-01
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Online Access: | https://www.frontiersin.org/article/10.3389/fpsyg.2020.00843/full |
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Article |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yidian Gao Yidian Gao Yidian Gao Yali Jiang Yali Jiang Yali Jiang Qingsen Ming Jibiao Zhang Jibiao Zhang Jibiao Zhang Ren Ma Ren Ma Ren Ma Qiong Wu Qiong Wu Qiong Wu Daifeng Dong Daifeng Dong Daifeng Dong Xiao Guo Xiao Guo Xiao Guo Mingli Liu Mingli Liu Mingli Liu Xiang Wang Xiang Wang Xiang Wang Weijun Situ Ruth Pauli Shuqiao Yao Shuqiao Yao Shuqiao Yao |
spellingShingle |
Yidian Gao Yidian Gao Yidian Gao Yali Jiang Yali Jiang Yali Jiang Qingsen Ming Jibiao Zhang Jibiao Zhang Jibiao Zhang Ren Ma Ren Ma Ren Ma Qiong Wu Qiong Wu Qiong Wu Daifeng Dong Daifeng Dong Daifeng Dong Xiao Guo Xiao Guo Xiao Guo Mingli Liu Mingli Liu Mingli Liu Xiang Wang Xiang Wang Xiang Wang Weijun Situ Ruth Pauli Shuqiao Yao Shuqiao Yao Shuqiao Yao Gray Matter Changes in the Orbitofrontal-Paralimbic Cortex in Male Youths With Non-comorbid Conduct Disorder Frontiers in Psychology conduct disorder comorbidities gray matter volume callous-unemotional traits VBM |
author_facet |
Yidian Gao Yidian Gao Yidian Gao Yali Jiang Yali Jiang Yali Jiang Qingsen Ming Jibiao Zhang Jibiao Zhang Jibiao Zhang Ren Ma Ren Ma Ren Ma Qiong Wu Qiong Wu Qiong Wu Daifeng Dong Daifeng Dong Daifeng Dong Xiao Guo Xiao Guo Xiao Guo Mingli Liu Mingli Liu Mingli Liu Xiang Wang Xiang Wang Xiang Wang Weijun Situ Ruth Pauli Shuqiao Yao Shuqiao Yao Shuqiao Yao |
author_sort |
Yidian Gao |
title |
Gray Matter Changes in the Orbitofrontal-Paralimbic Cortex in Male Youths With Non-comorbid Conduct Disorder |
title_short |
Gray Matter Changes in the Orbitofrontal-Paralimbic Cortex in Male Youths With Non-comorbid Conduct Disorder |
title_full |
Gray Matter Changes in the Orbitofrontal-Paralimbic Cortex in Male Youths With Non-comorbid Conduct Disorder |
title_fullStr |
Gray Matter Changes in the Orbitofrontal-Paralimbic Cortex in Male Youths With Non-comorbid Conduct Disorder |
title_full_unstemmed |
Gray Matter Changes in the Orbitofrontal-Paralimbic Cortex in Male Youths With Non-comorbid Conduct Disorder |
title_sort |
gray matter changes in the orbitofrontal-paralimbic cortex in male youths with non-comorbid conduct disorder |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Psychology |
issn |
1664-1078 |
publishDate |
2020-05-01 |
description |
Conduct disorder is one of the most common developmental psychiatric disorders which is characterized by persistent aggressive and antisocial behaviors during childhood or adolescence. Previous neuroimaging studies have investigated the neural correlates underlying CD and demonstrated several constructive findings. However, Individuals with CD are at high risk for comorbidities, which might give rise to the inconsistencies of existed findings. It remains unclear which neuroanatomical abnormalities are specifically related to CD without comorbidities. Using structural magnetic resonance imaging (sMRI) data of 69 CD and 69 typically developing (TD) male youths (aged 14–17 years), the present study aims at investigating gray matter volume alterations of non-comorbid CD (i.e., not comorbid with attention deficit hyperactivity disorder, substance abuse disorder, anxiety or depression). We also examined how regional gray matter volumes were related to callous-unemotional (CU) traits and conduct problems in the CD group. The whole-brain analysis revealed decreased gray matter volumes in the right pre-postcentral cortex, supramarginal gyrus and right putamen in CD youths compared with TD youths. The region-of-interest analyses showed increased gray matter volumes in the superior temporal gyrus (STG) and right orbitofrontal cortex (OFC) in CD youths. Correlation analysis found that gray matter volume in the left amygdala was negatively correlated with CU traits in CD participants. These results demonstrated that gray matter volume in the orbitofrontal-paralimbic cortex, including OFC, STG and amygdala, might characterize the male youths with non-comorbid CD and might contribute to different severe forms and trajectories of CD. |
topic |
conduct disorder comorbidities gray matter volume callous-unemotional traits VBM |
url |
https://www.frontiersin.org/article/10.3389/fpsyg.2020.00843/full |
work_keys_str_mv |
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doaj-506fb6e551a949daad34354e7e6a206d2020-11-25T02:19:33ZengFrontiers Media S.A.Frontiers in Psychology1664-10782020-05-011110.3389/fpsyg.2020.00843490934Gray Matter Changes in the Orbitofrontal-Paralimbic Cortex in Male Youths With Non-comorbid Conduct DisorderYidian Gao0Yidian Gao1Yidian Gao2Yali Jiang3Yali Jiang4Yali Jiang5Qingsen Ming6Jibiao Zhang7Jibiao Zhang8Jibiao Zhang9Ren Ma10Ren Ma11Ren Ma12Qiong Wu13Qiong Wu14Qiong Wu15Daifeng Dong16Daifeng Dong17Daifeng Dong18Xiao Guo19Xiao Guo20Xiao Guo21Mingli Liu22Mingli Liu23Mingli Liu24Xiang Wang25Xiang Wang26Xiang Wang27Weijun Situ28Ruth Pauli29Shuqiao Yao30Shuqiao Yao31Shuqiao Yao32Medical Psychological Center of Second Xiangya Hospital, Central South University, Changsha, ChinaMedical Psychological Institute of Central South University, Changsha, ChinaChina National Clinical Research Center on Mental Disorders (Xiangya), Changsha, ChinaMedical Psychological Center of Second Xiangya Hospital, Central South University, Changsha, ChinaMedical Psychological Institute of Central South University, Changsha, ChinaChina National Clinical Research Center on Mental Disorders (Xiangya), Changsha, ChinaDepartment of Psychiatry, The First Affiliated Hospital of Soochow University, Suzhou, ChinaMedical Psychological Center of Second Xiangya Hospital, Central South University, Changsha, ChinaMedical Psychological Institute of Central South University, Changsha, ChinaChina National Clinical Research Center on Mental Disorders (Xiangya), Changsha, ChinaMedical Psychological Center of Second Xiangya Hospital, Central South University, Changsha, ChinaMedical Psychological Institute of Central South University, Changsha, ChinaChina National Clinical Research Center on Mental Disorders (Xiangya), Changsha, ChinaMedical Psychological Center of Second Xiangya Hospital, Central South University, Changsha, ChinaMedical Psychological Institute of Central South University, Changsha, ChinaChina National Clinical Research Center on Mental Disorders (Xiangya), Changsha, ChinaMedical Psychological Center of Second Xiangya Hospital, Central South University, Changsha, ChinaMedical Psychological Institute of Central South University, Changsha, ChinaChina National Clinical Research Center on Mental Disorders (Xiangya), Changsha, ChinaMedical Psychological Center of Second Xiangya Hospital, Central South University, Changsha, ChinaMedical Psychological Institute of Central South University, Changsha, ChinaChina National Clinical Research Center on Mental Disorders (Xiangya), Changsha, ChinaMedical Psychological Center of Second Xiangya Hospital, Central South University, Changsha, ChinaMedical Psychological Institute of Central South University, Changsha, ChinaChina National Clinical Research Center on Mental Disorders (Xiangya), Changsha, ChinaMedical Psychological Center of Second Xiangya Hospital, Central South University, Changsha, ChinaMedical Psychological Institute of Central South University, Changsha, ChinaChina National Clinical Research Center on Mental Disorders (Xiangya), Changsha, ChinaDepartment of Radiology, Second Xiangya Hospital, Central South University, Changsha, ChinaCentre for Human Brain Health, School of Psychology, University of Birmingham, Birmingham, United KingdomMedical Psychological Center of Second Xiangya Hospital, Central South University, Changsha, ChinaMedical Psychological Institute of Central South University, Changsha, ChinaChina National Clinical Research Center on Mental Disorders (Xiangya), Changsha, ChinaConduct disorder is one of the most common developmental psychiatric disorders which is characterized by persistent aggressive and antisocial behaviors during childhood or adolescence. Previous neuroimaging studies have investigated the neural correlates underlying CD and demonstrated several constructive findings. However, Individuals with CD are at high risk for comorbidities, which might give rise to the inconsistencies of existed findings. It remains unclear which neuroanatomical abnormalities are specifically related to CD without comorbidities. Using structural magnetic resonance imaging (sMRI) data of 69 CD and 69 typically developing (TD) male youths (aged 14–17 years), the present study aims at investigating gray matter volume alterations of non-comorbid CD (i.e., not comorbid with attention deficit hyperactivity disorder, substance abuse disorder, anxiety or depression). We also examined how regional gray matter volumes were related to callous-unemotional (CU) traits and conduct problems in the CD group. The whole-brain analysis revealed decreased gray matter volumes in the right pre-postcentral cortex, supramarginal gyrus and right putamen in CD youths compared with TD youths. The region-of-interest analyses showed increased gray matter volumes in the superior temporal gyrus (STG) and right orbitofrontal cortex (OFC) in CD youths. Correlation analysis found that gray matter volume in the left amygdala was negatively correlated with CU traits in CD participants. These results demonstrated that gray matter volume in the orbitofrontal-paralimbic cortex, including OFC, STG and amygdala, might characterize the male youths with non-comorbid CD and might contribute to different severe forms and trajectories of CD.https://www.frontiersin.org/article/10.3389/fpsyg.2020.00843/fullconduct disordercomorbiditiesgray matter volumecallous-unemotional traitsVBM |