Methemoglobinemia due to quinine causing severe acute kidney injury in a child

• Main Authors: S Kudale, S K Sethi, M Dhaliwal, V Kher
• Format: Article
• Language: English
• Published: Wolters Kluwer Medknow Publications 2014-01-01
• Series: Indian Journal of Nephrology
• Subjects: Acute kidney injury; methemoglobinemia; quinine
• Online Access: http://www.indianjnephrol.org/article.asp?issn=0971-4065;year=2014;volume=24;issue=6;spage=394;epage=396;aulast=Kudale

Congenital methemoglobinemia is a rare condition resulting from a deficiency of nicotinamide adenine dinucleotide-cytochrome b5 reductase. Acquired methemoglobinemia may result due to certain drugs, chemicals and food items. Information on epidemiological determinants from India is sparse. This report describes methemoglobinemia in a 4-year-old child after parenteral administration of quinine causing acute kidney injury. This case emphasizes the need of awareness of potential adverse events of antimalarial drugs. Prompt management of methemoglobinemia is essential to avoid potential life-threatening complications.